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Human s100b Protein expressed in Escherichia coli (E. coli) - ABIN1097989
Cerofolini, Amato, Borsi, Pagano, Randazzo, Fragai: Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands. in Journal of molecular recognition : JMR 2015
Data (including data from studies in knockout mice) suggest that S100b acting as a humoral factor impairs glycolysis in muscle (myoblasts, myotubes, and skeletal muscles) independent of insulin (show INS Proteins) action; this effect appears to be due to inhibition of Gapdh (show GAPDH Proteins) activity from enhanced poly(ADP-ribosyl)ation of Gapdh (show GAPDH Proteins). (S100B = S100 protein, beta polypeptide (show MS4A2 Proteins), neural; Gapdh (show GAPDH Proteins) = glyceraldehyde-3-phosphate dehydrogenase (show GAPDH Proteins))
Data (including data from studies using knockout mice) suggest that S100A1 (show S100A1 Proteins) (S-100 calcium-binding protein (show GUCA1B Proteins) A1 (show BCL2A1 Proteins), alpha chain (show FCGRT Proteins)) is involved in protein kinase A- (RIIalpha and RIIbeta (show PRKAR2B Proteins))-dependent signaling resulting in nuclear redistribution/influx of HDAC4 (histone deacetylase 4 (show HDAC5 Proteins)) in skeletal muscle fibers.
S100B inhibits C3H/10T1/2 murine embryonic mesenchyma.l cells into osteoblasts. S100B stimulates C3H/10T1/2 cell differentiation into adipocytes.
The results of this study showed that S100B affects behavioral despair in female mice through functional interaction with the 5-HT7 receptor.
Data show that S100B has direct effects on macrophages, enhancing particularly CCL22 (show CCL22 Proteins) and IL-1beta (show IL1B Proteins) expression and modulates the inflammatory response in uveoretinitis and this is likely to be, at least in part, via a direct effect on macrophages.
Data show that high glucose increased protein-protein interaction between Steap4 (show STEAP4 Proteins) and S100B in mesangial (MES13) cells.
S100A1 (show S100A1 Proteins)-KO exhibited increased right ventricular (RV) weight and elevated RV pressure in the absence of altered left ventricular filling pressures, increase in wall thickness of muscularized pulmonary arteries and a reduction in microvascular perfusion.
high glucoseinduced profibrotic genes (TGFbeta (show TGFB1 Proteins), type IV collagen (show COL4 Proteins) and fibronectin (show FN1 Proteins)) and cell hypertrophyrelated p21WAF1 are dependent on S100B.
S100A1 (show S100A1 Proteins) and S100B are dispensable for endochondral ossification during skeletal development.
S100A1 ablationalso reduced plaque associated and increased non-plaque associated PO4-Akt and PO4-GSK3beta staining.
Levels of NSE (show ENO2 Proteins) and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies.
In vitro experiments using repeated freeze-thaw procedures showed an intracellular up-regulation of S100B in normal and vitiligo (show MITF Proteins) melanocytes before an extensive release in the environment.
Acute paranoid schizophrenia inpatients present a day/night change of S100B serum levels at admission that disappears at discharge.
Compared to the control, the S100B/GAPDH (show GAPDH Proteins) mRNA ratio was significantly decreased in chronic liver diseases (p = 0.006) and most decreased in chronic hepatitis C patients (p = 0.023). We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
results indicate there were decreased S100B serum levels in bipolar patients in a manic phase after treatment.
Studies indicate that S100 calcium binding protein B protein (S100B) has high affinity for zinc (Zn2+).
For patients recruited = 6 h after trauma, the CT-positive group indicated significantly higher levels of both H-FABP (show FABP3 Proteins) and S100B than the CT-negative group.
Our study provides information on the dynamic changes of MMP-9 (show MMP9 Proteins)-TIMP-1 (show TIMP1 Proteins) system and S100B in the perioperative period. Preoperative reduction of TIMP-1 (show TIMP1 Proteins) might be predictive for shunt requirement but future studies are required for verification.
a correlation between S100B + A1-positive Human Articular Chondrocytes in monolayer culture and their neochondrogenesis capacity in pellet culture, is reported.
this study shows that low levels of S100B correlate to a better anti-CTLA-4 (show CTLA4 Proteins) immunotherapy response and survival in advanced melanoma patients
As CSF (show CSF2 Proteins)-S100B levels in calves with neurologic diseases widely differed, the utility of CSF (show CSF2 Proteins)-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.
S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE (show AGER Proteins)-dependent regulation of several inflammation-related events including activation and migration of microglia
X-ray crystallography was used here to characterize an interaction between Ca(2 (show CA2 Proteins))(+)-S100B and TRTK-12, a target that binds to the p53 (show TP53 Proteins)-binding site on S100B.
Intracellular S100B might modulate myoblast differentiation by interfering with MyoD (show MYOD1 Proteins) expression in an NF-kappaB (show NFKB1 Proteins)-dependent manner.
S100b activates guanylate cyclase in a calcium-dependent manner [review]
Structural studies in combination with biochemical data are used to develop a model for calcium-induced activation of human nuclear serine/threonine kinase (NDR (show STK38 Proteins)) kinase by S100B.
S100B shows a sufficient thermostability to resist pasteurization but not spry-drying in milk formulas for preterm and term infants.
Structures of pentamidine (Pnt (show ETS2 Proteins)) bound to Ca(2 (show CA2 Proteins)+)-loaded and Zn(2+),Ca(2 (show CA2 Proteins)+)-loaded S100B were determined by X-ray crystallography at 2.15 A (R(free)=0.266) and 1.85 A (R(free)=0.243) resolution, respectively.
The time course of S100B serum values following spinal cord decompression correlates with outcome; the initial degree of paresis is not a prognostic factor to predict outcome.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21\; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
S-100 protein alpha chain
, S-100 protein subunit alpha
, S100 calcium-binding protein A1
, protein S100-A1
, S-100 calcium-binding protein, beta chain
, S-100 protein subunit beta
, S100 calcium-binding protein, beta (neural)
, protein S100-B
, S-100 protein beta chain
, S100 calcium-binding protein B
, S100 protein, beta polypeptide
, S-100 calcium-binding protein beta subunit
, S100 calcium-binding protein beta (neural)
, S100 protein, beta polypeptide, neural
, S100 calcium binding protein, beta (neural)
, S100 calcium-binding protein, beta