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significant co-localization of binding sites for MyoD (show MYOD1 Proteins) and Six proteins on over a thousand mouse genomic DNA regions, were found.
The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx (show DMD Proteins)) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD (show DMD Proteins).
results reveal a role for Six4 during adult muscle regeneration and suggest a widespread mechanism of cooperation between Six4 and MyoD (show MYOD1 Proteins).
the transcription factors Six1 (show SIX1 Proteins) and Six4 are required for male gonadal differentiation.
Direct molecular regulation of the myogenic determination gene Myf5 (show MYF5 Proteins) by Pax3 (show PAX3 Proteins), with modulation by Six1 (show SIX1 Proteins)/4 factors, is exemplified by the -111 kb-Myf5 (show MYF5 Proteins) enhancer
Data show that absence of Six1 (show SIX1 Proteins) and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program.
These results suggest that Six1 (show SIX1 Proteins) and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells.
Six4 and Six5 repressed, while Six1 (show SIX1 Proteins) activated myogenin (show MYOG Proteins) expression, suggesting that the differential regulation of myogenin (show MYOG Proteins) expression is responsible for the differential effects of Six genes
Six1 (show SIX1 Proteins) and Six4 expression is required to specifically activate fast-type muscle genes
Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase (show CKM Proteins) enhancer.
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
homeobox protein SIX4
, sine oculis homeobox homolog 4
, sine oculis-related homeobox 4 homolog
, skeletal muscle-specific ARE-binding protein AREC3