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Clathrin-mediated internalization of dopamine receptor D3 was responsible for lysosomal degradation.
Analysis of gene-gene interactions with CYP2B6 (show CYP2B6 Proteins) was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3.
DRD3 Ser9Gly polymorphism is nominally associated with changes in triglycerides and metabolic syndrome after 12 weeks of standard BDII treatment.
Regarding the DRD3 Ser9Gly polymorphism, individuals with a greater number of the Gly alleles, which are related to an increased dopamine release in the striatum, were more susceptible to social influence.
DRD3 gene expression reduction in breast cancer patients after spiritual intervention
This study showed a lack of association between of DRD3 rs6280 with the risk for essential tremor.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2 (show Slc18a2 Proteins), DRD1 (show DRD1 Proteins), DRD3 and COMT (show COMT Proteins). Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Proteins) locus and the 5 from the MAOA (show MAOA Proteins) locus showed significant associations with excessive alcohol consumption.
The combination of MTHFR (show MTHFR Proteins), DRD3 and MDR1 polymorphisms associated with a slow ATV (show NBN Proteins) metabolizer phenotype
The DRD3 (rs6280) polymorphism influences younger Parkinson disease age of onset in the US Caucasian population.
A significant positive correlation was found between the DRD3 mRNA level and the score of the excited factor in patients with schizophrenia/schizophreniform disorder.
this study shows that D3R regulates the effect of methamphetamine on LPS (show TLR4 Proteins)-induced mast cells activation
This study show the Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP (show ADCYAP1 Proteins) and receptors and alters their cortical distribution.
Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R (show DRD1 Proteins)-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord.
Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF (show BDNF Proteins) in place preference acquisition
Results suggest that the dopamine D3 receptor is centrally involved in the etiology of adult anxiety- and depression-related behaviors that arise from repeated stressful experiences during childhood.
D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam
The dopamine receptor D1 (show DRD1 Proteins) but not the D3 is also critical for morphine-induced BDNF (show BDNF Proteins) expression.
Study identified a unique role for Npas2 (show NPAS2 Proteins) in the regulation of cocaine reward and dopamine Drd3 receptor expression
D5 regulate CD4 (show CD4 Proteins)(+)T-cell activation and differentiation by modulating ERK (show EPHB2 Proteins) activation and cAMP production.
This study demonstrated that Low dose pramipexole causes D3 receptor-independent reduction of locomotion and responding for a conditioned reinforce/
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
D(3) dopamine receptor
, dopamine receptor D3
, dopamine receptor 3
, dopamine D3 receptor
, dopaminergic receptor D3
, essential tremor 1
, D3 receptor