Browse our ASS1 Proteins (ASS1)

Full name:
Argininosuccinate Synthase 1 Proteins (ASS1)
On are 20 Argininosuccinate Synthase 1 (ASS1) Proteins from 8 different suppliers available. Additionally we are shipping ASS1 Antibodies (100) and ASS1 Kits (15) and many more products for this protein. A total of 142 ASS1 products are currently listed.
AA408052, Ass, Ass-1, ASSA, CTLN1, fold, wu:fb95a04, wu:fc01e08, zgc:92051
list all proteins Gene Name GeneID UniProt
ASS1 445 P00966
ASS1 25698 P09034
ASS1 11898 P16460

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ASS1 Proteins (ASS1) by Origin

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Top referenced ASS1 Proteins

  1. Human ASS1 Protein expressed in Escherichia coli (E. coli) - ABIN667156 : Kobayashi, Jackson, Tick, OBrien, Beaudet: Heterogeneity of mutations in argininosuccinate synthetase causing human citrullinemia. in The Journal of biological chemistry 1990 (PubMed)

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Human Argininosuccinate Synthase 1 (ASS1) interaction partners

  1. Low ASS1 expression was associated with higher recurrence , shorter disease-free survival and shorter overall survival in patients with pancreatic ductal adenocarcinoma.

  2. The authors showed that ASS1 mutations linked to type I citrullinemia disrupt the ASS1-PRMT7 (show PRMT7 Proteins) interaction, which might explain the molecular pathogenesis of the disease.

  3. Identification of three novel CTLN1 mutations in fourteen patients with citrullinemia type 1 has been reported.

  4. In this trial, arginine deprivation with ADI-PEG20 improved PFS in patients with ASS1-deficient mesothelioma. Targeting arginine is safe and warrants further clinical investigation in arginine-dependent cancers.

  5. combining hypoxia and ADI-PEG20 synergistically inhibited ASS1.

  6. ASS1 genomic variants (rs10901080 and rs10793902) can serve as pharmacogenomic biomarkers to predict hydroxyurea treatment efficacy in sickle cell disease/beta-thalassemia compound heterozygous patients.

  7. results show that ASS1 is elevated at the mRNA and protein levels in mesothelioma 3D spheroids and in human pleural mesotheliomas. We also have uncovered a survival role for ASS1

  8. results demonstrate that ASS1 downregulation is a novel mechanism supporting cancerous proliferation, and they provide a metabolic link between the urea cycle enzymes and pyrimidine synthesis

  9. More than 50 % of the high-grade pulmonary neuroendocrine carcinomas tested lack immunohistochemically detectable ASS, suggesting that they are auxotrophic for arginine and potential candidates for arginine deprivation therapy.

  10. Three novel splicing and missense mutations have been identified in the ASS1 gene in classical citrullinemia patients.

Cow (Bovine) Argininosuccinate Synthase 1 (ASS1) interaction partners

  1. calcium-dependent phosphorylation of argininosuccinate synthase Ser (show SIGLEC1 Proteins)-328 is mediated by PKCalpha (show PKCa Proteins)

  2. dose-dependent reduction of ASS as a result of siRNA treatment corresponded to diminished capacity to produce NO, despite saturating levels of arginine in the medium; reduced expression of ASS resulted in loss of viability due to apoptosis

  3. In endothelial cells TNF-alpha (show TNF Proteins) coordinately downregulates nitric oxide synthase (eNOS (show NOS3 Proteins)) and argininosuccinate synthase expression, resulting in a severely impaired citrulline-NO cycle.

  4. These results represent the first demonstration that vascular endothelial nitric oxide production can be regulated by dynamic argininosuccinate synthase phosphorylation.

Mouse (Murine) Argininosuccinate Synthase 1 (ASS1) interaction partners

  1. In diabetic mice, ablation of Ass resulted in diminished endothelium-derived nitric oxide-mediated vascular relaxation responses.

  2. cAMP-induced Ass1 expression is important in controlling the magnitude of decidualization through regulating L-Arg level.

  3. We demonstrate that the transgenic mouse system reported here has the merit of sensitivity and direct visualization advantage, and is ideal for annotating temporal and spatial expression profiles and the regulation mode of the ASS gene.

  4. Thus, extracellular arginine fuels rapid NO production in activated macrophages, and citrulline recycling via Ass1 and Asl (show ADSL Proteins) is a fail-safe system that sustains optimum NO production.

  5. Partial argininosuccinate synthase ablation protects only in acute ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario where oxidative stress and impaired fatty acid beta-oxidation are key events.

  6. Loss of Ass1 is associated with citrullinemia type I and other hyperammonemic syndromes.

ASS1 Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with ASS1

  • argininosuccinate synthase 1 (ASS1)
  • argininosuccinate synthetase 1 (ass1)
  • argininosuccinate synthase 1 (ass1)
  • argininosuccinate synthase 1 (Ass1)
  • argininosuccinate synthetase 1 (Ass1)
  • AA408052 protein
  • Ass protein
  • Ass-1 protein
  • ASSA protein
  • CTLN1 protein
  • fold protein
  • wu:fb95a04 protein
  • wu:fc01e08 protein
  • zgc:92051 protein

Protein level used designations for ASS1

argininosuccinate synthetase 1 , argininosuccinate synthase , citrulline--aspartate ligase , arginosuccinate synthetase , argininosuccinate synthase 1 , argininosuccinate synthase-like , citrulline-aspartate ligase , citrullinemia , arginosuccinate synthetase 1

414411 Sus scrofa
447864 Danio rerio
496645 Xenopus (Silurana) tropicalis
100218639 Taeniopygia guttata
100396479 Callithrix jacchus
100465731 Ailuropoda melanoleuca
100602356 Nomascus leucogenys
445 Homo sapiens
480693 Canis lupus familiaris
280726 Bos taurus
25698 Rattus norvegicus
417185 Gallus gallus
380488 Xenopus laevis
11898 Mus musculus
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