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Placental lactogen is expressed but is not translated into protein in breast cancer.
These results indicate that placental lactogen induces CYP2E1 (show CYP2E1 ELISA Kits) expression via PI3-kinase (show PIK3CA ELISA Kits) pathway in human hepatocytes.
Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta.
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
Data conclude that members of the C/EBP (show CEBPA ELISA Kits) and Ets (show ETS1 ELISA Kits) families can differentially modulate CS-Benh and CS-Aenh activity.
hPL (show LGALS1 ELISA Kits)-A is involved in the regulation of pancreatic beta cells activity.
Results strongly support a conformationally mediated obligate-ordered prolactin receptor (show PRLR ELISA Kits) binding for each of the three lactogenic hormones: prolactin (show PRL ELISA Kits), growth hormone (show GH1 ELISA Kits), and placental lactogen.
The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth.
Investigation of the GRB2 (show GRB2 ELISA Kits), GRB7 (show GRB7 ELISA Kits), and CSH1 genes as candidates for the Silver-Russell syndrome (SRS (show SMS ELISA Kits)) on chromosome 17q.
a role for CSH1 haploinsufficiency in the etiology of growth retardation
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
, chorionic somatomammotropin A
, chorionic somatomammotropin hormone
, placental lactogen