You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SIPA1 Proteins (SIPA1)

Full name:
Signal-Induced Proliferation-Associated 1 Proteins (SIPA1)
On are 3 Signal-Induced Proliferation-Associated 1 (SIPA1) Proteins from 2 different suppliers available. Additionally we are shipping SIPA1 Antibodies (96) and SIPA1 Kits (3) and many more products for this protein. A total of 107 SIPA1 products are currently listed.
list all proteins Gene Name GeneID UniProt
SIPA1 20469  
SIPA1 6494 Q96FS4
Rat SIPA1 SIPA1 361710  

Show all synonyms

SIPA1 Proteins (SIPA1) by Origin

Select your origin of interest

More Proteins for SIPA1 Interaction Partners

Mouse (Murine) Signal-Induced Proliferation-Associated 1 (SIPA1) interaction partners

  1. Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.

  2. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.

  3. afadin regulates the cyclical activation and inactivation of Rap1 (show TERF2IP Proteins), Rac1, and RhoA (show RHOA Proteins) through SPA-1 and ARAP1 (show ARAP1 Proteins).

Human Signal-Induced Proliferation-Associated 1 (SIPA1) interaction partners

  1. Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA (show VEGFA Proteins). Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA (show VEGFA Proteins) expression to increase vascular density.

  2. results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis

  3. Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression.

  4. nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling.

  5. BRD4 (show BRD4 Proteins) short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.

  6. SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors.

  7. Polymorphism in Sipa1 promoter gene is associated with lung cancer.

  8. Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042).

  9. SIPA1 expression is increased in human colorectal cancer.

  10. In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 (show MMP9 Proteins) after controlling for stage and lymphvascular space invasion.

SIPA1 Protein Profile

Protein Summary

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Alternative names and synonyms associated with SIPA1

  • signal-induced proliferation-associated 1 (SIPA1)
  • Signal peptidase I (leader peptidase I) (sipA1)
  • signal-induced proliferation associated gene 1 (Sipa1)
  • signal-induced proliferation-associated 1 (Sipa1)
  • SPA1 protein

Protein level used designations for SIPA1

signal-induced proliferation-associated gene 1 , Signal peptidase I (leader peptidase I) , signal-induced proliferation-associated 1 , signal-induced proliferation-associated protein 1-like , GTPase-activating protein Spa-1 , signal-induced proliferation-associated protein 1 , sipa-1 , p130 SPA-1

715958 Macaca mulatta
3778279 Lactobacillus sakei subsp. sakei 23K
100385492 Callithrix jacchus
100579653 Nomascus leucogenys
20469 Mus musculus
6494 Homo sapiens
361710 Rattus norvegicus
483730 Canis lupus familiaris
100517325 Sus scrofa
508234 Bos taurus
Selected quality suppliers for SIPA1 Proteins (SIPA1)
Did you look for something else?