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Browse our anti-Calreticulin (CALR) Antibodies

Full name:
anti-Calreticulin Antibodies (CALR)
On www.antibodies-online.com are 288 Calreticulin (CALR) Antibodies from 30 different suppliers available. Additionally we are shipping Calreticulin Kits (59) and Calreticulin Proteins (48) and many more products for this protein. A total of 415 Calreticulin products are currently listed.
Synonyms:
anon-EST:fe3D7, anon-EST:Liang-2.11, anon-EST:Liang-2.17, CALR, Calregulin, cC1qR, CG9429, clone 2.11, clone 2.17, Clr, crc, CRP55, CRT, Dmel\\CG9429, ERp60, eth, HACBP, NV19007, potp, RO, SSA, zgc:85636

Most Popular Reactivities for anti-Calreticulin (CALR) Antibodies

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anti-Human Calreticulin Antibodies:

anti-Mouse (Murine) Calreticulin Antibodies:

anti-Rat (Rattus) Calreticulin Antibodies:

All available anti-Calreticulin Antibodies

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Top referenced anti-Calreticulin Antibodies

  1. Human Monoclonal Calreticulin Primary Antibody for WB - ABIN394076 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN394076

  2. Human Monoclonal Calreticulin Primary Antibody for IF, WB - ABIN968752 : Ito, Seyama, Kubota: Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 4 references for ABIN968752

  3. Dog (Canine) Polyclonal Calreticulin Primary Antibody for IF, IHC (p) - ABIN265295 : Kageyama, Isono, Matsuda, Ushio, Satomura, Terai, Arai, Kawakita, Okada, Yoshiki: Urinary calreticulin in the diagnosis of bladder urothelial carcinoma. in International journal of urology : official journal of the Japanese Urological Association 2009 (PubMed)
    Show all 3 references for ABIN265295

  4. Human Monoclonal Calreticulin Primary Antibody for ICC, IHC - ABIN1724687 : Tan, Chen, Li, Mabuchi, Bouvier: The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain. in Biochimica et biophysica acta 2006 (PubMed)

  5. Human Polyclonal Calreticulin Primary Antibody for FACS, IHC (p) - ABIN390885 : Alur, Nguyen, Eggener, Jiang, Dadras, Stern, Kimm, Roehl, Kozlowski, Pins, Michalak, Dhir, Wang: Suppressive roles of calreticulin in prostate cancer growth and metastasis. in The American journal of pathology 2009 (PubMed)

  6. Dog (Canine) Polyclonal Calreticulin Primary Antibody for IHC, WB - ABIN2779285 : Urade, Okudo, Kato, Moriyama, Arakaki: ER-60 domains responsible for interaction with calnexin and calreticulin. in Biochemistry 2004 (PubMed)

More Antibodies against Calreticulin Interaction Partners

Fruit Fly (Drosophila melanogaster) Calreticulin (CALR) interaction partners

  1. Calreticulin plays a key role in olfactory system function, possibly by establishing its overall sensitivity to odorants.

  2. Calreticulin mediates hypersensitivity to diethylether and resistance to isoflurane in association with low expression of the gene.

  3. These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes

Human Calreticulin (CALR) interaction partners

  1. Alterated IQGAP1 (show IQGAP1 Antibodies)/Rho GTPase (show RACGAP1 Antibodies) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2 (show JAK2 Antibodies)/CALR mutational status.

  2. Recurrent somatic mutations in calreticulin (CALR) gene that encodes a molecular chaperone (show HSP90AA1 Antibodies) residing in the endoplasmic reticulum were identified in 2013 in a subset of patients with myeloproliferative neoplasms (MPNs).

  3. These results indicate that mutant CALR causes myeloproliferation because of the activation of JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathway and not by the inhibition of phagocytosis, which is similar to the myeloproliferation caused by JAK2 (show JAK2 Antibodies) V617F mutation.

  4. our studies demonstrate that occasional patients with CALR mutation-positive ET or MF carry other MPN (show PRSS27 Antibodies)-initiating genetic mutations (including JAK2 (show JAK2 Antibodies) V617F), acquire "secondary mutations" before or after the CALR mutation, or evolve over time to being CALR mutation-homozygous.

  5. The meta-analysis of the different populations (including Asian, European, North American and Australian) showed that CALR mutation may increase the prevalence of patients with essential thrombocythemia (19%) and primary myelofibrosis (22%).

  6. CALR- and JAK2 (show JAK2 Antibodies)-mutated MPNs are broadly similar in terms of the quantity, frequency and spectrum of co-occurring mutations and therefore observed biological differences are likely to not be heavily influenced by the nature and quantity of co-mutated genes.

  7. The family with JAK2 (show JAK2 Antibodies) G571S mutations reported here teaches us that 1 germline JAK2 (show JAK2 Antibodies) mutation may hide a somatic CALR mutation, and that, in this case, the phenotype (thrombocytosis) and disease (essential thrombocythemia [ET]) are likely due to the somatic CALR mutation. This highlights the complexity of making the diagnosis of ET (vs. HT) in a familial context.

  8. From included 1138 patients vascular risk patients, 18 individuals were tested positive for the JAK2 (show JAK2 Antibodies) V617F mutation. CALR exon 9 mutations were not detected in any of our patients. CALR exon 9 mutations are infrequent in vascular risk patients.

  9. CALR mutations are rarely involved in myelodysplastic syndromes with myelofibrosis

  10. Genotyping for CALR could be a useful diagnostic tool for JAK2 (show JAK2 Antibodies)/MPL (show MPL Antibodies)-negative ET, since the data suggest that CALR is much more prevalent than MPL (show MPL Antibodies), therefore testing for CALR should be considered in patients who are JAK2 (show JAK2 Antibodies) negative as its frequency is almost 20 times that of MPL (show MPL Antibodies) mutation.

Rabbit Calreticulin (CALR) interaction partners

  1. These findings suggest that protein kinase C (show PKC Antibodies) is involved in the regulation of CRT function.

Mouse (Murine) Calreticulin (CALR) interaction partners

  1. a profound impairment in calreticulin function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin within the endoplasmic reticulum.

  2. This essential role of calreticulin in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  3. Study provides evidence that chronic stress activates calreticulin and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  4. This study for the first time revealed that increased CRT (show SLC6A8 Antibodies) inhibited Fas (show FAS Antibodies)/FasL (show FASL Antibodies)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  5. The findings highlight the importance of CALR in female reproduction and demonstrate that compromised CALR function leads to ovarian insufficiency and female infertility.

  6. Calreticulin mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  7. CALR mutants are sufficient to induce thrombocytosis through MPL (show MPL Antibodies) activation.

  8. Thrombopoietin receptor (show MPL Antibodies) activation by myeloproliferative neoplasm associated calreticulin mutants.

  9. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin-substrate interactions and as key determinants of PLC (show HSPG2 Antibodies) dynamics.

  10. study demonstrates for the first time that LRH-1 (show NR5A2 Antibodies) has a CRT (show SLC6A8 Antibodies)-dependent NES (show NES Antibodies) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

Cow (Bovine) Calreticulin (CALR) interaction partners

  1. the lectin site of CRT is the main target for gentamicin binding

Pig (Porcine) Calreticulin (CALR) interaction partners

  1. Calreticulin is confined to subplasmalemmal vesicles partially overlapping with cortical granule contents. Its exocytosis after the oocyte activation seems to participate in the membrane block to polyspermy in pigs.

  2. Calreticulin was widely expressed in pig tissues and its transcripts were downregulated during maturation, especially at 44 hr, and were undetectable at the blastocyst stage.

Calreticulin (CALR) Antigen Profile

Antigen Summary

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Alternative names and synonyms associated with Calreticulin (CALR)

  • calreticulin (calr) antibody
  • calreticulin (crt) antibody
  • calreticulin (CRT) antibody
  • Calreticulin (Crc) antibody
  • calreticulin (LmjF31.2600) antibody
  • calreticulin (Crc) antibody
  • calreticulin (CALR) antibody
  • calreticulin (Calr) antibody
  • calreticulin (Crt) antibody
  • calreticulin 2, calcium-binding protein (CRT2) antibody
  • calreticulin 3 (CALR3) antibody
  • anon-EST:fe3D7 antibody
  • anon-EST:Liang-2.11 antibody
  • anon-EST:Liang-2.17 antibody
  • CALR antibody
  • Calregulin antibody
  • cC1qR antibody
  • CG9429 antibody
  • clone 2.11 antibody
  • clone 2.17 antibody
  • Clr antibody
  • crc antibody
  • CRP55 antibody
  • CRT antibody
  • Dmel\\CG9429 antibody
  • ERp60 antibody
  • eth antibody
  • HACBP antibody
  • NV19007 antibody
  • potp antibody
  • RO antibody
  • SSA antibody
  • zgc:85636 antibody

Protein level used designations for anti-Calreticulin (CALR) Antibodies

calreticulin , CG9429-PA , CG9429-PB , Crc-PA , Crc-PB , anon-fast-evolving-3D7 , pot pourri , potpourri , ER-resident chaperone calreticulin , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , CABP3 , CALBP , calcium-binding protein 3 , calrectulin , Endoplasmic reticulum resident protein 60

GENE ID SPECIES
379788 Xenopus laevis
100136202 Oncorhynchus mykiss
100146083 Triticum aestivum
30248 Danio rerio
41166 Drosophila melanogaster
407962 Xenopus (Silurana) tropicalis
5654192 Leishmania major strain Friedlin
100116123 Nasonia vitripennis
100304608 Ictalurus punctatus
811 Homo sapiens
476694 Canis lupus familiaris
100009050 Oryctolagus cuniculus
12317 Mus musculus
64202 Rattus norvegicus
281036 Bos taurus
100381266 Sus scrofa
101104396 Ovis aries
100713922 Cavia porcellus
692629 Bombyx mori
100689096 Cricetulus griseus
5715514 Chlamydomonas reinhardtii
420146 Gallus gallus
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