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Browse our anti-SLC6A8 (SLC6A8) Antibodies

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anti-Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 Antibodies (SLC6A8)
On are 41 Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) Antibodies from 14 different suppliers available. Additionally we are shipping SLC6A8 Kits (15) and SLC6A8 Proteins (4) and many more products for this protein. A total of 67 SLC6A8 products are currently listed.
AA589632, Calregulin, cC1qR, CCDS1, CHOT1, CHT1, Creat, CRT, CRTR, CT1, RO, SLC6A8, SSA
list all antibodies Gene Name GeneID UniProt
SLC6A8 811 P27797
SLC6A8 12317 P14211
SLC6A8 50690 P28570

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Most Popular Reactivities for anti-SLC6A8 (SLC6A8) Antibodies

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anti-Human SLC6A8 Antibodies:

anti-Mouse (Murine) SLC6A8 Antibodies:

anti-Rat (Rattus) SLC6A8 Antibodies:

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Top referenced anti-SLC6A8 Antibodies

  1. Human Polyclonal SLC6A8 Primary Antibody for ELISA, WB - ABIN1451640 : Sandoval, Bauer, Brenner, Coy, Drescher, Kioschis, Korn, Nyakatura, Poustka, Reichwald, Rosenthal, Platzer: The genomic organization of a human creatine transporter (CRTR) gene located in Xq28. in Genomics 1996 (PubMed)

  2. Cow (Bovine) Polyclonal SLC6A8 Primary Antibody for IHC, WB - ABIN2775317 : Dodd, Christie: Substituted cysteine accessibility of the third transmembrane domain of the creatine transporter: defining a transport pathway. in The Journal of biological chemistry 2005 (PubMed)

  3. Cow (Bovine) Polyclonal SLC6A8 Primary Antibody for WB - ABIN2775318 : Anselm, Coulter, Darras: Cardiac manifestations in a child with a novel mutation in creatine transporter gene SLC6A8. in Neurology 2008 (PubMed)

More Antibodies against SLC6A8 Interaction Partners

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. Alterated IQGAP1 (show IQGAP1 Antibodies)/Rho GTPase (show RACGAP1 Antibodies) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2 (show JAK2 Antibodies)/CALR (show CALR Antibodies) mutational status.

  2. Recurrent somatic mutations in calreticulin (CALR (show CALR Antibodies)) gene that encodes a molecular chaperone (show HSP90AA1 Antibodies) residing in the endoplasmic reticulum were identified in 2013 in a subset of patients with myeloproliferative neoplasms (MPNs).

  3. These results indicate that mutant CALR (show CALR Antibodies) causes myeloproliferation because of the activation of JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathway and not by the inhibition of phagocytosis, which is similar to the myeloproliferation caused by JAK2 (show JAK2 Antibodies) V617F mutation.

  4. our studies demonstrate that occasional patients with CALR (show CALR Antibodies) mutation-positive ET or MF carry other MPN (show PRSS27 Antibodies)-initiating genetic mutations (including JAK2 (show JAK2 Antibodies) V617F), acquire "secondary mutations" before or after the CALR (show CALR Antibodies) mutation, or evolve over time to being CALR (show CALR Antibodies) mutation-homozygous.

  5. The meta-analysis of the different populations (including Asian, European, North American and Australian) showed that CALR (show CALR Antibodies) mutation may increase the prevalence of patients with essential thrombocythemia (19%) and primary myelofibrosis (22%).

  6. CALR (show CALR Antibodies)- and JAK2 (show JAK2 Antibodies)-mutated MPNs are broadly similar in terms of the quantity, frequency and spectrum of co-occurring mutations and therefore observed biological differences are likely to not be heavily influenced by the nature and quantity of co-mutated genes.

  7. The family with JAK2 (show JAK2 Antibodies) G571S mutations reported here teaches us that 1 germline JAK2 (show JAK2 Antibodies) mutation may hide a somatic CALR (show CALR Antibodies) mutation, and that, in this case, the phenotype (thrombocytosis) and disease (essential thrombocythemia [ET]) are likely due to the somatic CALR (show CALR Antibodies) mutation. This highlights the complexity of making the diagnosis of ET (vs. HT) in a familial context.

  8. From included 1138 patients vascular risk patients, 18 individuals were tested positive for the JAK2 (show JAK2 Antibodies) V617F mutation. CALR (show CALR Antibodies) exon 9 mutations were not detected in any of our patients. CALR (show CALR Antibodies) exon 9 mutations are infrequent in vascular risk patients.

  9. CALR (show CALR Antibodies) mutations are rarely involved in myelodysplastic syndromes with myelofibrosis

  10. Genotyping for CALR (show CALR Antibodies) could be a useful diagnostic tool for JAK2 (show JAK2 Antibodies)/MPL (show MPL Antibodies)-negative ET, since the data suggest that CALR (show CALR Antibodies) is much more prevalent than MPL (show MPL Antibodies), therefore testing for CALR (show CALR Antibodies) should be considered in patients who are JAK2 (show JAK2 Antibodies) negative as its frequency is almost 20 times that of MPL (show MPL Antibodies) mutation.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. a profound impairment in calreticulin (show CALR Antibodies) function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin (show CALR Antibodies) within the endoplasmic reticulum.

  2. This essential role of calreticulin (show CALR Antibodies) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  3. Study provides evidence that chronic stress activates calreticulin (show CALR Antibodies) and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  4. This study for the first time revealed that increased CRT inhibited Fas (show FAS Antibodies)/FasL (show FASL Antibodies)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  5. The findings highlight the importance of CALR (show CALR Antibodies) in female reproduction and demonstrate that compromised CALR (show CALR Antibodies) function leads to ovarian insufficiency and female infertility.

  6. Calreticulin (show CALR Antibodies) mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  7. CALR (show CALR Antibodies) mutants are sufficient to induce thrombocytosis through MPL (show MPL Antibodies) activation.

  8. Thrombopoietin receptor (show MPL Antibodies) activation by myeloproliferative neoplasm associated calreticulin (show CALR Antibodies) mutants.

  9. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin (show CALR Antibodies)-substrate interactions and as key determinants of PLC (show HSPG2 Antibodies) dynamics.

  10. study demonstrates for the first time that LRH-1 (show NR5A2 Antibodies) has a CRT-dependent NES (show NES Antibodies) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt (show AKT1 Antibodies).

  2. Mammalian target of rapamycin (mTOR (show FRAP1 Antibodies)) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1 (show SGK1 Antibodies).

  3. The observations suggest that SGK1 (show SGK1 Antibodies) regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve (show PIKFYVE Antibodies).

SLC6A8 Antigen Profile

Antigen Summary

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC6A8

  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (SLC6A8) antibody
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (slc6a8) antibody
  • calreticulin (CALR) antibody
  • calreticulin (Calr) antibody
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8) antibody
  • solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8) antibody
  • solute carrier family 6 (neurotransmitter transporter), member 8 (Slc6a8) antibody
  • AA589632 antibody
  • Calregulin antibody
  • cC1qR antibody
  • CCDS1 antibody
  • CHOT1 antibody
  • CHT1 antibody
  • Creat antibody
  • CRT antibody
  • CRTR antibody
  • CT1 antibody
  • RO antibody
  • SLC6A8 antibody
  • SSA antibody

Protein level used designations for SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8 , Sodium- and chloride-dependent creatine transporter 1 , ct1 , sodium- and chloride-dependent creatine transporter 1-like , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , sodium- and chloride-dependent creatine transporter 1 , CT1 , choline transporter , creatine transporter 1 , solute carrier family 6 member 8 , creatine transporter, solute carrier family 6, member 8 , solute carrier family 6, member 8 , creatine transporter SLC6A8

473853 Pan troglodytes
567544 Danio rerio
698307 Macaca mulatta
100127575 Xenopus (Silurana) tropicalis
100404520 Callithrix jacchus
100440816 Pongo abelii
100589275 Nomascus leucogenys
811 Homo sapiens
12317 Mus musculus
492242 Canis lupus familiaris
100302506 Sus scrofa
282367 Bos taurus
100009280 Oryctolagus cuniculus
102857 Mus musculus
6535 Homo sapiens
50690 Rattus norvegicus
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