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Browse our SLC6A8 Proteins (SLC6A8)

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Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 Proteins (SLC6A8)
On are 5 Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) Proteins from 4 different suppliers available. Additionally we are shipping SLC6A8 Antibodies (42) and SLC6A8 Kits (18) and many more products for this protein. A total of 72 SLC6A8 products are currently listed.
AA589632, Calregulin, cC1qR, CCDS1, CHOT1, CHT1, Creat, CRT, CRTR, CT1, RO, SLC6A8, SSA
list all proteins Gene Name GeneID UniProt
SLC6A8 811 P27797
SLC6A8 12317 P14211
Rat SLC6A8 SLC6A8 50690 P28570

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SLC6A8 Proteins (SLC6A8) by Origin

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More Proteins for SLC6A8 Interaction Partners

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. Various calreticulin (show CALR Proteins) mutations were found in exon 9. Type 1 mutations, a 52-bp deletion in exon 9, were the most common and were observed in 23 cases. Type 2 mutations, a 5-bp insertion in exon 9, were identified in seven cases.

  2. Thrombocytosis and STAT5 (show STAT5A Proteins) activation in chronic myelogenous leukaemia are not consistently associated with CALR (show CALR Proteins) exon 9 or JAK2 (show JAK2 Proteins) V617F mutation.

  3. results suggest that calreticulin (show CALR Proteins) can serve as a biomarker of pancreatic cancer stem-like cells and a prognostic factor associated with poorer survival of pancreatic cancer patients

  4. overexpression of calreticulin(CALR (show CALR Proteins)) and heat shock 70kDa (show RPS6KB1 Proteins) protein 5 (show CAPS Proteins)(HSPA5 (show HSPA5 Proteins)) was further validated. CONCLUSION: Alltogether, abundant new candidate molecules, especially proteins related to ER-stress, were found to be involved in the pathogenesis of GD

  5. Data show that the median calreticulin (CALR (show CALR Proteins))mut (show MUT Proteins) allelic burden at diagnosis was significantly higher in primary myelofibrosis (PMF (show PRB1 Proteins)) patients as compared to essential thrombocythemia (ET) case.

  6. Studies indicate that a genetic classification of primary fibrosis (PMF (show PRB1 Proteins)) by calreticulin (CALR (show CALR Proteins)) and JAK2V617F (JAK2 (show JAK2 Proteins))mutations carried significant prognostic relevance.

  7. The present study demonstrated that a novel CRT missense mutation in exon 12 of the SLC6A8 gene (c.1681G>C; p.G561R) causes suppression of creatine transport activity

  8. Mutation status of JAK2 (show JAK2 Proteins), CALR (show CALR Proteins), and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.

  9. we show that the positive charge of the CALR (show CALR Proteins) mutant C-terminus is necessary to transform hematopoietic cells by enabling binding between mutant CALR (show CALR Proteins) and the thrombopoietin receptor MPL (show MPL Proteins).

  10. CALR (show CALR Proteins) is not only a potential diagnostic molecular marker but also adds relevant prognostic information as it is associated with milder clinical and haematological characteristics compared to the JAK2V617F-mutated or 'triple-negative' patients.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. This essential role of calreticulin (show CALR Proteins) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  2. Study provides evidence that chronic stress activates calreticulin (show CALR Proteins) and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  3. This study for the first time revealed that increased CRT inhibited Fas (show FAS Proteins)/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  4. The findings highlight the importance of CALR (show CALR Proteins) in female reproduction and demonstrate that compromised CALR (show CALR Proteins) function leads to ovarian insufficiency and female infertility.

  5. Calreticulin (show CALR Proteins) mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  6. CALR (show CALR Proteins) mutants are sufficient to induce thrombocytosis through MPL (show MPL Proteins) activation.

  7. Thrombopoietin receptor (show MPL Proteins) activation by myeloproliferative neoplasm associated calreticulin (show CALR Proteins) mutants.

  8. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin (show CALR Proteins)-substrate interactions and as key determinants of PLC (show HSPG2 Proteins) dynamics.

  9. study demonstrates for the first time that LRH-1 (show NR5A2 Proteins) has a CRT-dependent NES (show NES Proteins) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

  10. Arginylated CRT has a longer half-life than non-arginylated CRT and displays different ubiquitin dependence.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt (show AKT1 Proteins).

  2. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1 (show SGK1 Proteins).

  3. The observations suggest that SGK1 (show SGK1 Proteins) regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve (show PIKFYVE Proteins).

SLC6A8 Protein Profile

Protein Summary

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC6A8

  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (slc6a8)
  • calreticulin (CALR)
  • calreticulin (Calr)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (Slc6a8)
  • AA589632 protein
  • Calregulin protein
  • cC1qR protein
  • CCDS1 protein
  • CHOT1 protein
  • CHT1 protein
  • Creat protein
  • CRT protein
  • CRTR protein
  • CT1 protein
  • RO protein
  • SLC6A8 protein
  • SSA protein

Protein level used designations for SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8 , Sodium- and chloride-dependent creatine transporter 1 , ct1 , sodium- and chloride-dependent creatine transporter 1-like , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , sodium- and chloride-dependent creatine transporter 1 , CT1 , choline transporter , creatine transporter 1 , solute carrier family 6 member 8 , creatine transporter, solute carrier family 6, member 8 , solute carrier family 6, member 8 , creatine transporter SLC6A8

473853 Pan troglodytes
567544 Danio rerio
698307 Macaca mulatta
100127575 Xenopus (Silurana) tropicalis
100404520 Callithrix jacchus
100440816 Pongo abelii
100589275 Nomascus leucogenys
811 Homo sapiens
12317 Mus musculus
492242 Canis lupus familiaris
100302506 Sus scrofa
282367 Bos taurus
100009280 Oryctolagus cuniculus
102857 Mus musculus
6535 Homo sapiens
50690 Rattus norvegicus
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