Browse our SLC6A8 Proteins (SLC6A8)

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Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 Proteins (SLC6A8)
On are 4 Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) Proteins from 3 different suppliers available. Additionally we are shipping SLC6A8 Antibodies (42) and SLC6A8 Kits (15) and many more products for this protein. A total of 68 SLC6A8 products are currently listed.
AA589632, Calregulin, cC1qR, CCDS1, CHOT1, CHT1, Creat, CRT, CRTR, CT1, RO, SLC6A8, SSA
list all proteins Gene Name GeneID UniProt
SLC6A8 811 P27797
SLC6A8 12317 P14211
Rat SLC6A8 SLC6A8 50690 P28570

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SLC6A8 Proteins (SLC6A8) by Origin

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More Proteins for SLC6A8 Interaction Partners

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. CRT exposure represents a novel powerful prognostic biomarker for patients with acute myeloid leukemia (show BCL11A Proteins).

  2. In absence of CALR (show CALR Proteins), immature MPO (show MPO Proteins) protein precursors are degraded in the proteasome.

  3. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones

  4. Coexisting mutations of the JAK2 (show JAK2 Proteins), CALR (show CALR Proteins), and MPL (show MPL Proteins) genes in myeloproliferative neoplasms suggest that CALR (show CALR Proteins) and MPL (show MPL Proteins) should be analyzed not only in JAK2 (show JAK2 Proteins)-negative patients but also in low V617F mutation patients.

  5. CALR (show CALR Proteins)-mutated essential thrombocythemia (ET) patients harbored a higher mutant load at progenitor level than JAK2V617F-positive ET (HSCs: 39.9% vs 7.5% p<0.001, hematopoietic stem cells)

  6. Results indicate that NGF (show NGFB Proteins) inhibited CRT translocation induced by mitoxantrone. NGF (show NGFB Proteins) effect on CRT translocation could have consequences in immunotherapy, potentially lessening the effectiveness of this type of treatment.

  7. The consistent association between Calr (show CALR Proteins) and Dio2 (show DIO2 Proteins) expression suggests that enhanced expression of these two genes facilitate detrimental effects on cartilage integrity.

  8. The myeloproliferative neoplasms (MPNs) patients carrying Calreticulin(CALR (show CALR Proteins)) mutations presented with higher platelet counts and lower hemoglobin (show HBB Proteins) levels compared to those with mutated JAK2 (show JAK2 Proteins). However, all of the leukemia patients had negative results for CALR (show CALR Proteins) mutations.

  9. Alterated IQGAP1/Rho GTPase (show RACGAP1 Proteins) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2 (show JAK2 Proteins)/CALR (show CALR Proteins) mutational status.

  10. Recurrent somatic mutations in calreticulin (CALR (show CALR Proteins)) gene that encodes a molecular chaperone (show HSP90AA1 Proteins) residing in the endoplasmic reticulum were identified in 2013 in a subset of patients with myeloproliferative neoplasms (MPNs).

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. the results of this investigation provide the first molecular insights into the phospholipid binding site of calreticulin (show CALR Proteins) as a key anchor point for the cell surface expression of calreticulin (show CALR Proteins) on apoptotic cells

  2. a profound impairment in calreticulin (show CALR Proteins) function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin (show CALR Proteins) within the endoplasmic reticulum.

  3. This essential role of calreticulin (show CALR Proteins) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  4. Study provides evidence that chronic stress activates calreticulin (show CALR Proteins) and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  5. This study for the first time revealed that increased CRT inhibited Fas (show FAS Proteins)/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  6. The findings highlight the importance of CALR (show CALR Proteins) in female reproduction and demonstrate that compromised CALR (show CALR Proteins) function leads to ovarian insufficiency and female infertility.

  7. Calreticulin (show CALR Proteins) mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  8. CALR (show CALR Proteins) mutants are sufficient to induce thrombocytosis through MPL (show MPL Proteins) activation.

  9. Thrombopoietin receptor (show MPL Proteins) activation by myeloproliferative neoplasm associated calreticulin (show CALR Proteins) mutants.

  10. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin (show CALR Proteins)-substrate interactions and as key determinants of PLC (show HSPG2 Proteins) dynamics.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt (show AKT1 Proteins).

  2. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1 (show SGK1 Proteins).

  3. The observations suggest that SGK1 (show SGK1 Proteins) regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve (show PIKFYVE Proteins).

SLC6A8 Protein Profile

Protein Summary

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC6A8

  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (slc6a8)
  • calreticulin (CALR)
  • calreticulin (Calr)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (Slc6a8)
  • AA589632 protein
  • Calregulin protein
  • cC1qR protein
  • CCDS1 protein
  • CHOT1 protein
  • CHT1 protein
  • Creat protein
  • CRT protein
  • CRTR protein
  • CT1 protein
  • RO protein
  • SLC6A8 protein
  • SSA protein

Protein level used designations for SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8 , Sodium- and chloride-dependent creatine transporter 1 , ct1 , sodium- and chloride-dependent creatine transporter 1-like , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , sodium- and chloride-dependent creatine transporter 1 , CT1 , choline transporter , creatine transporter 1 , solute carrier family 6 member 8 , creatine transporter, solute carrier family 6, member 8 , solute carrier family 6, member 8 , creatine transporter SLC6A8

473853 Pan troglodytes
567544 Danio rerio
698307 Macaca mulatta
100127575 Xenopus (Silurana) tropicalis
100404520 Callithrix jacchus
100440816 Pongo abelii
100589275 Nomascus leucogenys
811 Homo sapiens
12317 Mus musculus
492242 Canis lupus familiaris
100302506 Sus scrofa
282367 Bos taurus
100009280 Oryctolagus cuniculus
102857 Mus musculus
6535 Homo sapiens
50690 Rattus norvegicus
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