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Browse our SLC6A8 Proteins (SLC6A8)

Full name:
Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 Proteins (SLC6A8)
On www.antibodies-online.com are 5 Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) Proteins from 4 different suppliers available. Additionally we are shipping SLC6A8 Antibodies (42) and SLC6A8 Kits (18) and many more products for this protein. A total of 72 SLC6A8 products are currently listed.
Synonyms:
AA589632, Calregulin, cC1qR, CCDS1, CHOT1, CHT1, Creat, CRT, CRTR, CT1, RO, SLC6A8, SSA
list all proteins Gene Name GeneID UniProt
SLC6A8 811 P27797
SLC6A8 12317 P14211
Rat SLC6A8 SLC6A8 50690 P28570

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SLC6A8 Proteins (SLC6A8) by Origin

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More Proteins for SLC6A8 Interaction Partners

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. Mutation status of JAK2 (show JAK2 Proteins), CALR (show CALR Proteins), and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.

  2. we show that the positive charge of the CALR (show CALR Proteins) mutant C-terminus is necessary to transform hematopoietic cells by enabling binding between mutant CALR (show CALR Proteins) and the thrombopoietin receptor MPL (show MPL Proteins).

  3. CALR (show CALR Proteins) is not only a potential diagnostic molecular marker but also adds relevant prognostic information as it is associated with milder clinical and haematological characteristics compared to the JAK2V617F-mutated or 'triple-negative' patients.

  4. The incidence of calreticulin (show CALR Proteins) mutations in essential thrombocythemia and primary myelofibrosis was 24.2% and increased to 50.0% in JAK2 (show JAK2 Proteins) V617F-negative cases. Essential thrombocythemia patients carrying calreti mutations were younger, showed lower WBC counts, and experienced less thrombosis than did those carrying the JAK2 (show JAK2 Proteins) V617F mutation, although no differences in other clinical features and prognosis were demonstrated.

  5. Anagrelide proved effective among all molecular subsets, indicating that JAK2 (show JAK2 Proteins)/CALR (show CALR Proteins)/MPL (show MPL Proteins) mutational status does not seem to represent a major determinant of choice of cytoreductive treatment among essential thrombocythemia therapies.

  6. This essential role of calreticulin (show CALR Proteins) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  7. Data suggest that a specific plasma membrane transporter, creatine transporter (SLC6A8), enables cells to incorporate creatine; creatine uptake is controlled by AMP-activated protein kinase (show PRKAA2 Proteins), a ubiquitous sensor of energy depletion. [REVIEW]

  8. Evaluation of the role of JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway in the oncogenic effect of calreticulin (show CALR Proteins) mutants in myeloproliferative neoplasms (review).

  9. Letter: CALR (show CALR Proteins) mutations are rare in Chinese Budd-Chiari syndrome patients.

  10. CALR (show CALR Proteins) mutated clones are present in bone marrow cells of essential thrombocythemia and primary myelofibrosis patients.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. This essential role of calreticulin (show CALR Proteins) in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  2. Study provides evidence that chronic stress activates calreticulin (show CALR Proteins) and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  3. This study for the first time revealed that increased CRT inhibited Fas (show FAS Proteins)/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  4. The findings highlight the importance of CALR (show CALR Proteins) in female reproduction and demonstrate that compromised CALR (show CALR Proteins) function leads to ovarian insufficiency and female infertility.

  5. Calreticulin (show CALR Proteins) mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  6. CALR (show CALR Proteins) mutants are sufficient to induce thrombocytosis through MPL (show MPL Proteins) activation.

  7. Thrombopoietin receptor (show MPL Proteins) activation by myeloproliferative neoplasm associated calreticulin (show CALR Proteins) mutants.

  8. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin (show CALR Proteins)-substrate interactions and as key determinants of PLC (show HSPG2 Proteins) dynamics.

  9. study demonstrates for the first time that LRH-1 (show NR5A2 Proteins) has a CRT-dependent NES (show NES Proteins) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

  10. Arginylated CRT has a longer half-life than non-arginylated CRT and displays different ubiquitin dependence.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8) interaction partners

  1. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1 (show SGK1 Proteins).

  2. The observations suggest that SGK1 (show SGK1 Proteins) regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve (show PIKFYVE Proteins).

SLC6A8 Protein Profile

Protein Summary

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC6A8

  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (slc6a8)
  • calreticulin (CALR)
  • calreticulin (Calr)
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8)
  • solute carrier family 6 (neurotransmitter transporter), member 8 (Slc6a8)
  • AA589632 protein
  • Calregulin protein
  • cC1qR protein
  • CCDS1 protein
  • CHOT1 protein
  • CHT1 protein
  • Creat protein
  • CRT protein
  • CRTR protein
  • CT1 protein
  • RO protein
  • SLC6A8 protein
  • SSA protein

Protein level used designations for SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8 , Sodium- and chloride-dependent creatine transporter 1 , ct1 , sodium- and chloride-dependent creatine transporter 1-like , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , sodium- and chloride-dependent creatine transporter 1 , CT1 , choline transporter , creatine transporter 1 , solute carrier family 6 member 8 , creatine transporter, solute carrier family 6, member 8 , solute carrier family 6, member 8 , creatine transporter SLC6A8

GENE ID SPECIES
473853 Pan troglodytes
567544 Danio rerio
698307 Macaca mulatta
100127575 Xenopus (Silurana) tropicalis
100404520 Callithrix jacchus
100440816 Pongo abelii
100589275 Nomascus leucogenys
811 Homo sapiens
12317 Mus musculus
492242 Canis lupus familiaris
100302506 Sus scrofa
282367 Bos taurus
100009280 Oryctolagus cuniculus
102857 Mus musculus
6535 Homo sapiens
50690 Rattus norvegicus
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