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DDX6 modulates interaction of miR (show MLXIP Proteins)-122 with the 5' untranslated region of hepatitis C virus RNA.
we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis.
miRNAs, AGOs, GW182, the CCR4 (show CCR4 Proteins)-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells
DDX6 may have a role in radio- and chemoresistance in glioblastoma
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
DDX6 repression complexes are required for P-body assembly.
Protein Interactome Analysis of DDX6
Results indicate that progenitor function is maintained by DDX6 complexes through two distinct pathways that include the degradation of differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs.
CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway.
study discovered multiple susceptibility variants for systemic lupus erythematosus in the 11q23.3 region, including variants in/near PHLDB1 (rs11603023), DDX6 (rs638893) and CXCR5 (show CXCR5 Proteins) (rs10892301)
Xp54nrb (show NONO Proteins) transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and Xp54nrb (show NONO Proteins) could be involved in anterior neural patterning
An oligomerized form of p54 (show ETS1 Proteins) RNA helicase represses mRNA translation.
Data show that RNA helicase DDX6 colocalizes with ubiquitin-protein ligase (show UBE2K Proteins) TRIM32 (show TRIM32 Proteins) in neural stem cells and neurons and that it increases the activity of microRNA Let-7a.
rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals
rck/p54 protein was ubiquitously expressed in mouse tissues
RCK/ p54 might be a determinant of colorectal cancer proliferation by activating the canonical Wnt (show WNT2 Proteins) pathway
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
, DEAD box protein 6
, RNA helicase p54
, probable ATP-dependent RNA helicase ddx6
, ATP-dependent RNA helicase p54
, DEAD box-6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
, oncogene RCK
, probable ATP-dependent RNA helicase DDX6
, ATP-dependent RNA helicase ddx6
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
, oncogene RCK homolog