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DDX6 Products

(DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6))

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This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].

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Featured DDX6 Categories

DDX6 Antibodies

High quality antibodies with extensive validation data.

DDX6 ELISA Kits

Reliable ELISA kits for a wide range of species.

DDX6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DDX6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC (p), RNAi, ELISA, WB
Validations
  • (3)
  • (5)
Cat. No. ABIN560590
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (4)
Cat. No. ABIN185580
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (4)
Cat. No. ABIN514941
Quantity 100 μg
Datasheet Datasheet

Recommended DDX6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1772198
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774646
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1746179
Quantity 96 tests
Datasheet Datasheet

Recommended DDX6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3078758
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3119818
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351382
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DDX6 products

Li, Chen, Xu, Jones, Tiwari, Ling, Wang, Harismendy, Sen: "HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs." in: Nature communications, Vol. 10, Issue 1, pp. 4198, (2019) (PubMed).

Di Stefano, Luo, Haggerty, Aigner, Charlton, Brumbaugh, Ji, Rabano Jiménez, Clowers, Huebner, Clement, Lipchina, de Kort, Anselmo, Pulice, Gerli, Gu, Gygi, Sadreyev, Meissner, Yeo, Hochedlinger: "The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis." in: Cell stem cell, Vol. 25, Issue 5, pp. 622-638.e13, (2019) (PubMed).

Sharma, Majerciak, Kruhlak, Yu, Kang, Yang, Gu, Fritzler, Zheng: "KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182." in: Nucleic acids research, Vol. 47, Issue 17, pp. 9368-9385, (2019) (PubMed).

Paul, Dansithong, Figueroa, Scoles, Pulst: "Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration." in: Nature communications, Vol. 9, Issue 1, pp. 3648, (2018) (PubMed).

Hubstenberger, Courel, Bénard, Souquere, Ernoult-Lange, Chouaib, Yi, Morlot, Munier, Fradet, Daunesse, Bertrand, Pierron, Mozziconacci, Kress, Weil: "P-Body Purification Reveals the Condensation of Repressed mRNA Regulons." in: Molecular cell, Vol. 68, Issue 1, pp. 144-157.e5, (2017) (PubMed).

Ayache, Bénard, Ernoult-Lange, Minshall, Standart, Kress, Weil: "P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes." in: Molecular biology of the cell, Vol. 26, Issue 14, pp. 2579-95, (2016) (PubMed).

Somasekharan, El-Naggar, Leprivier, Cheng, Hajee, Grunewald, Zhang, Ng, Delattre, Evdokimova, Wang, Gleave, Sorensen: "YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1." in: The Journal of cell biology, Vol. 208, Issue 7, pp. 913-29, (2015) (PubMed).

Nicklas, Okawa, Hillje, González-Cano, Del Sol, Schwamborn: "The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs." in: Nucleic acids research, Vol. 43, Issue 5, pp. 2638-54, (2015) (PubMed).

Kawahara, Yokota, Fujita: "DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells." in: Histochemistry and cell biology, Vol. 141, Issue 1, pp. 111-21, (2014) (PubMed).

Kaehler, Isensee, Hucho, Lehrach, Krobitsch: "5-Fluorouracil affects assembly of stress granules based on RNA incorporation." in: Nucleic acids research, Vol. 42, Issue 10, pp. 6436-47, (2014) (PubMed).

Synonyms and alternative names related to DDX6

DEAD-box helicase 6 (DDX6), DEAD (Asp-Glu-Ala-Asp) box helicase 6 (ddx6), DEAD-box helicase 6 (ddx6), DEAD-box helicase 6 L homeolog (ddx6.L), DEAD-box helicase 6 (Ddx6), DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 (Ddx6), 1110001P04Rik, E230023J21Rik, hlr2, HLR2, me31b, mRCK/P54, p54, P54, P54H, p54h, rck, RCK, RGD1564560, si:ch211-147p17.1, Xp54

Protein level used designations for DDX6

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
  • DEAD box protein 6
  • RNA helicase p54
  • probable ATP-dependent RNA helicase ddx6
  • ATP-dependent RNA helicase p54
  • DEAD box-6
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
  • oncogene RCK
  • probable ATP-dependent RNA helicase DDX6
  • ATP-dependent RNA helicase ddx6
  • xp54
  • D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
  • DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
  • oncogene RCK homolog
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