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Propose that eIF6 is necessary for malignant pleural mesothelioma growth.
EIF6 plays an important role in controlling cell motility and tumor metastasis.
eIF6 is a node regulator of ribosomal function and predict that prioritizing its pharmacological targeting will be of benefit in cancer and Shwachman-Bodian-Diamond syndrome
SBDS (show SBDS Proteins) protein facilitates the release of eIF6, a factor that prevents ribosome joining.
eIF6 is one of the downstream effectors of Notch-1 (show NOTCH1 Proteins) in the pathway that controls cell motility and invasiveness in tumor cell lines
The interactions between P311 (show C5orf13 Proteins) and ITGB4BP may be very important in the process of tumor cell differentiation and metastasis.
The benign prognosis of the Shwachman-Diamond syndrome patients with the int del (20)(q11.21q13.32) may be due to a gene/dosage effect for the EIF6 protein.
Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6) and hnRNA splicing (SF3B2 (show SF3B2 Proteins)/SF3B4 (show SF3B4 Proteins)), showed that human T cells can enter the cell cycle without growing in size.
a direct role for SBDS (show SBDS Proteins) and EFL1 (show EFNA1 Proteins) in catalyzing the translational activation of ribosomes in all eukaryotes, and define SDS (show SDS Proteins) as a ribosomopathy caused by uncoupling GTP (show AK3 Proteins) hydrolysis from eIF6 release
P311 (show C5orf13 Proteins) and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway.
eIF6 relieved fibrosis/cicatrization by inhibiting the generation of VEGF (show VEGFA Proteins) to prevent the overgrowth of blood vessels and production of granulation tissues, and by regulating the MMP-2 (show MMP2 Proteins)/TIMP-2 (show TIMP2 Proteins) balance to promote ECM (show MMRN1 Proteins) degradation and decrease its deposition.
data reveal a novel transcriptional regulatory mechanism of eIF6 that acts on facilitating Sp1 (show SP1 Proteins) recruitment to TGF-beta1 (show TGFB1 Proteins) promoter via H2A.Z (show H2AFZ Proteins) depletion and thus results in increased TGF-beta1 (show TGFB1 Proteins) transcription, which contributes to myofibroblast differentiation.
Reduced eIF6 expression negatively impacts on megakaryopoiesis. in eIF6(+/-) cells, the steady-state abundance of mitochondrial respiratory chain complex I-encoding mRNAs is decreased, resulting in decreased reactive oxygen species production.
eIF6 controls fatty acid synthesis and glycolysis in a cell autonomous fashion. Translational activation by eIF6 reshapes gene expression with increased levels of lipogenic and glycolytic enzymes.
In a murine model of lymphomagenesis, eIF6 depletion leads to a striking increase of survival, without adverse effects.
eIF6 is a rate-limiting controller of initiation of translation, able to affect tumorigenesis and tumor growth.
eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals
aberrant eye phenotype, produced by eif6 overexpression, is not directly linked to the PKC-regulated effects of eif6 on translation and ribosomal subunit interaction
The higher presence of p27BBP/eIF6 would appear related to an increased need of apoptosis control in the regions where cell death is essential for normal development.
Xp27(BBP (show TM2D1 Proteins))/eIF6 is part of a mechanism acting on the specific translation of messengers regulating cell survival; Xp27(BBP (show TM2D1 Proteins))/eIF6 may regulate the translation of factors upstream of Bcl-2 (show BCL2 Proteins)/Bax (show BAX Proteins).
The distribution of p27BBP/eIF6 and its association with the cytoskeleton varies according to oogenesis stages.
p27BBP/eIF6 expression is modulated during embryogenesis in differentiating anlagens and may suggest a correlation between p27BBP/eIF6 and proliferative activity.
results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
B4 integrin interactor
, eukaryotic translation initiation factor 3A
, p27 beta-4 integrin-binding protein
, imc-415 homolog
, integrin beta 4 binding protein
, eukaryotic translation initiation factor 6