Browse our PQBP1 Proteins (PQBP1)

Full name:
Polyglutamine Binding Protein 1 Proteins (PQBP1)
On are 15 Polyglutamine Binding Protein 1 (PQBP1) Proteins from 5 different suppliers available. Additionally we are shipping PQBP1 Antibodies (42) and PQBP1 Kits (3) and many more products for this protein. A total of 63 PQBP1 products are currently listed.
MRX55, MRXS3, MRXS8, npw38, PQBP-1, PQBP1, RENS1, Sfc2, SHS
list all proteins Gene Name GeneID UniProt
PQBP1 10084 O60828
PQBP1 54633 Q91VJ5
Rat PQBP1 PQBP1 302557 Q6PCT5

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PQBP1 Proteins (PQBP1) by Origin

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Top referenced PQBP1 Proteins

  1. Human PQBP1 Protein expressed in Escherichia coli (E. coli) - ABIN1098284 : Waragai, Junn, Kajikawa, Takeuchi, Kanazawa, Shibata, Mouradian, Okazawa: PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 2 references for 1098284

More Proteins for PQBP1 Interaction Partners

Human Polyglutamine Binding Protein 1 (PQBP1) interaction partners

  1. Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP (show FMR1 Proteins) function may be beneficial for those patients

  2. results suggest that the interaction between PQBP1 and WBP11 (show WBP11 Proteins) negatively modulates the U5-15kD (show TXNL4A Proteins) binding of PQBP1 by an allosteric mechanism

  3. Study found that PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 Proteins)-dependent innate response.

  4. Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein (show SF3B4 Proteins) U5-15 kD.

  5. These data demonstrate a role for PQBP1 in the modulation of stress granules.

  6. Data show that the PQBP1 mutation was found in 3 brothers with a phenotype comprising MR, short stature, lean body and microcephaly.

  7. Evidence for a functional involvement of the four mutations affecting ATRX (show ATRX Proteins) (p.1761M4T), PQBP1 (p.155R4X), and SLC6A8 (show SLC6A8 Proteins) (p.390P4L and p.477S4L), in the etiology of intellectual disability.

  8. Whole gene duplication of the PQBP1 gene in syndrome resembling Renpenning.

  9. mutations in PQBP1 caused variable loss of cell adhesion from impaired vesicle trafficking disrupts the neuroepithelial lining or neuronal migration and underlies periventricular heterotopia formation

  10. frameshift mutations in the PQBP-1 gene lead to expression of mutants lacking the ability to interact with U5-15kD (show TXNL4A Proteins)

Mouse (Murine) Polyglutamine Binding Protein 1 (PQBP1) interaction partners

  1. This study demonstrated that in utero gene therapy for Pqbp1-cKO mice by intraperitoneal injection of the PQBP1-AAV vector at E10 successfully rescued microcephaly with preserved cortical structures and improved behavioral abnormalities in Pqbp1-cKO mice.

  2. These findings define PQBP1 and Dynamin 2 (show DNM2 Proteins) as components of a signaling pathway that orchestrates neuronal ciliary morphogenesis in the brain.

  3. The results indicated that Sox2 (show SOX2 Proteins) regulated the transcription of PQBP1 in neural stem progenitor cells.

  4. PQBP1 can affect the alternative splicing of multiple mRNAs and indicate specific affected targets whose splice site determination may contribute to the disease phenotype in PQBP1-linked neurological disorders

  5. PQBP1 dysfunction in regulating gene expression underlies the abnormal behavior and cognition of PQBP1-Knock-down mice.

  6. PQBP-1 might be involved in neuronal proliferation and/or maturation

PQBP1 Protein Profile

Protein Summary

This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Alternative names and synonyms associated with PQBP1

  • polyglutamine binding protein 1 (PQBP1)
  • polyglutamine binding protein 1 (LOC100345368)
  • polyglutamine binding protein 1 (Pqbp1)
  • MRX55 protein
  • MRXS3 protein
  • MRXS8 protein
  • npw38 protein
  • PQBP-1 protein
  • PQBP1 protein
  • RENS1 protein
  • Sfc2 protein
  • SHS protein

Protein level used designations for PQBP1

polyglutamine binding protein 1 , 38 kDa nuclear protein containing a WW domain , nuclear protein containing WW domain 38 kD , polyglutamine tract-binding protein 1 , polyglutamine-binding protein 1 , PQBP-1 , scurfy candidate 2

739437 Pan troglodytes
100345368 Oryctolagus cuniculus
10084 Homo sapiens
480909 Canis lupus familiaris
534894 Bos taurus
54633 Mus musculus
302557 Rattus norvegicus
100620849 Sus scrofa
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