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The expression of GRIM-1 and GRP78 (show HSPA5 Proteins) was negatively correlated in human non-small cell lung cancer (NSCLC) tissues, and the down-regulation of GRP78 (show HSPA5 Proteins) by GRIM-1 provides a possible mechanism for their interaction.
these results provide insight into the Shq1/dyskerin (Cbf5 (show DKC1 Proteins)) interaction that plays a critical role in H/ACA RNP (show RNPC3 Proteins) biogenesis and assembly in eukaryotes
study suggests that GRIM-1 (SHQ1) might act as a co-tumor suppressor in the prostate
SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009
protein SHQ1 homolog
, SHQ1 homolog