You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our anti-SMN1 (SMN1) Antibodies

Full name:
anti-Survival Motor Neuron 1 Antibodies (SMN1)
On are 4 Survival Motor Neuron 1 (SMN1) Antibodies from 3 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 5 SMN1 products are currently listed.
AI849087, BCD541, C-BCD541, GEMIN1, SMN, SMN1, SMNC, TDRD16B
list all antibodies Gene Name GeneID UniProt
Anti-Mouse SMN1 SMN1 20595 P97801
Anti-Rat SMN1 SMN1 64301 O35876
SMN1 6607 Q16637

Show all species

Show all synonyms

Most Popular Reactivities for anti-SMN1 (SMN1) Antibodies

Select your species and application

anti-Human SMN1 Antibodies:

All available anti-SMN1 Antibodies

Go to our pre-filtered search.

More Antibodies against SMN1 Interaction Partners

Mouse (Murine) Survival Motor Neuron 1 (SMN1) interaction partners

  1. Itch monoubiquitinates SMN (show STMN1 Antibodies) and monoubiquitination of SMN (show STMN1 Antibodies) plays an important role in regulating its cellular localization.

  2. muscle does not appear to require high levels of SMN (show STMN1 Antibodies) above what is produced by two copies of SMN2

  3. Findings demonstrate that high expression of SMN (show STMN1 Antibodies) in the motor neuron is both necessary and sufficient for proper function of the motor unit. In addition, SMN (show STMN1 Antibodies) high expression in neurons and glia has a major impact on survival.

  4. This study identifies pathways related to the function of Smn (show STMN1 Antibodies) and associated with differential motor unit vulnerability, thus presenting a number of exciting targets for future therapeutic development.

  5. Smn (show STMN1 Antibodies) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

  6. Primary cell culture and two different SMA model mice to demonstrate that reduced levels of Smn (show STMN1 Antibodies) lead to a profound disruption in the expression of myogenic genes.

  7. Results suggest that SMN (show STMN1 Antibodies) plays a role in the maintenance of pluripotent embryonic stem cells and neuronal differentiation in mice.

  8. AAV9-mediated SMN (show STMN1 Antibodies) gene therapy elicits cure for spinal muscular atrophy.

  9. Data show that changes in U12 introns-dependent splicing become apparent after prolonged/extensive survival motor neuron proteins SMN (show STMN1 Antibodies) depletion.

  10. This work both reveals a new autoregulatory pathway governing SMN (show STMN1 Antibodies) expression, and identifies a new mechanism through which SMN (show STMN1 Antibodies) can modulate specific mRNA expression via Gemin5 (show GEMIN5 Antibodies).

Cow (Bovine) Survival Motor Neuron 1 (SMN1) interaction partners

  1. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  2. SMN (show SNRPN Antibodies) protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase

Human Survival Motor Neuron 1 (SMN1) interaction partners

  1. Deletion in SMN2 gene is associated with spinal muscular atrophy.

  2. Thus, we can conclude that SMN2 methylation may regulate the SMA disease phenotype by modulating its transcription.

  3. This study demonstrated that Deficiency of the Survival of SMN2 Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

  4. Inverse correlation was observed between SMN2, SERF1A and NAIP (show NAIP Antibodies) copy number polymorphism and spinal muscular atrophy type.

  5. Loss of SMN2 expression is associated with Spinal muscular atrophy.

  6. Depletion of two of the most potent inhibitors of SMP2 (show LPIN3 Antibodies) exon 7 inclusion, SRSF2 (show SRSF2 Antibodies) or SRSF3 (show SRSF3 Antibodies), in cell lines derived from SMA patients, increased SMN2 exon 7 inclusion and SMN (show STMN1 Antibodies) protein level.

  7. Smn (show STMN1 Antibodies) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

  8. results indicate that high expression level of Tra2-beta1 is responsible for increased SMN2 exon 7 inclusion in the testis of SMA mice.

  9. In the Serbian patients with spinal muscular atrophy, a higher SMN2 gene copy number correlated with less severe disease phenotype.

  10. The copy numbers and gene structures of SMN2 genes were different in Chinese spinal muscular atrophy patients and healthy controls.

SMN1 Antigen Profile

Antigen Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with SMN1

  • survival motor neuron (SMN) antibody
  • survival motor neuron 1 (Smn1) antibody
  • survival of motor neuron 1, telomeric (SMN1) antibody
  • survival of motor neuron 1, telomeric (Smn1) antibody
  • survival of motor neuron 2, centromeric (SMN2) antibody
  • AI849087 antibody
  • BCD541 antibody
  • C-BCD541 antibody
  • GEMIN1 antibody
  • SMN antibody
  • SMN1 antibody
  • SMNC antibody
  • TDRD16B antibody

Protein level used designations for SMN1

survival motor neuron protein , survival of motor neuron protein , survival motor neuron 1 , component of gems 1 , gemin-1 , tudor domain containing 16B

403896 Canis lupus familiaris
493923 Felis catus
20595 Mus musculus
281492 Bos taurus
64301 Rattus norvegicus
6607 Homo sapiens
Selected quality suppliers for anti-SMN1 (SMN1) Antibodies
Did you look for something else?