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Using a conditional allele for Braf (show BRAF ELISA Kits)(V600E) , a mutation observed in clinical cases of GIST, authors observed that Braf (show BRAF ELISA Kits)(V600E) activation was sufficient to drive ICC hyperplasia but not GIST tumorigenesis.
This study detected the BrafV637E mutation by whole-exome analysis in 4/4 hepatic tumors induced by neonatal treatment with diethylnitrosamine (DEN) in male B6C3F1 mice.
a critical threshold for inhibition of MAPK (show MAPK1 ELISA Kits) signaling is required to optimally restore expression of thyroid differentiation genes in thyroid cells and in mice with BrafV600E-induced thyroid cancer.
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
these contrasting signatures precisely match those proposed to confer bias toward Hras (show HRAS ELISA Kits)(CAA61CTA) versus Braf (show BRAF ELISA Kits)(GTG636GAG) mutations in the original tumor sets. Our findings highlight a novel mechanism whereby exposure history acts through strand-biased mutagenesis to specify activation of preferred oncogenes
these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK (show MAPK14 ELISA Kits) signaling cascade.
BRAF (show BRAF ELISA Kits) V600E inhibition stimulates AMP-activated protein kinase (show PRKAA2 ELISA Kits)-mediated autophagy in colorectal cancer cells.
these data confirm the existence of a negative feedback pathway by which BRAF (show BRAF ELISA Kits) protein stability is regulated by ERK (show EPHB2 ELISA Kits).
coexpression of BRAF (show BRAF ELISA Kits)(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene (show RAB1A ELISA Kits)-induced senescence
findings suggest that targeting ErbB-3 (show ERBB3 ELISA Kits) receptors could represent an effective therapeutic approach in BRAF (show BRAF ELISA Kits)-V600E mutant colon cancer
Overexpression of SNRPE is associated with highly aggressive breast cancers.
Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex
In the SME intron, the position of the branchpoint A residue within the region base paired with U12 differs from that in P120 and XTF.
growth arrest by SmE directly correlates with the reduction of cyclin E (show CCNE1 ELISA Kits), CDK2 (show CDK2 ELISA Kits), CDC25C (show CDC25C ELISA Kits) and CDC2 (show CDK1 ELISA Kits) expression, and up-regulation of p27Kip
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5 (By similarity).
small nuclear ribonucleoprotein polypeptide E
, B-Raf proto-oncogene serine/threonine-protein kinase (p94)
, proto-oncogene B-Raf
, serine/threonine-protein kinase B-raf
, sm protein E
, small nuclear ribonucleoprotein E
, SmE protein
, v-raf murine sarcoma viral oncogene homolog B1