Browse our ATP2B4 Proteins (ATP2B4)

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ATPase, Ca++ Transporting, Plasma Membrane 4 Proteins (ATP2B4)
On are 10 ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) Proteins from 3 different suppliers available. Additionally we are shipping ATP2B4 Antibodies (32) and many more products for this protein. A total of 45 ATP2B4 products are currently listed.
ATP2B1, atp2b2, atp2b3, ATP2B4, mxra1, Pmca4, pmca4b, pmca4x, zgc:152801
list all proteins Gene Name GeneID UniProt
ATP2B4 493 P23634
Rat ATP2B4 ATP2B4 29600 Q64542
ATP2B4 381290  

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ATP2B4 Proteins (ATP2B4) by Origin

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More Proteins for ATP2B4 Interaction Partners

Cow (Bovine) ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.

  2. results indicate possible functional compartmentalization of PMCA in bull sperm membranes and point to a presumptive, interaction partner of Ca(2+)-ATPase and PDC-109.

  3. thermodynamic analysis of mitochondrial F1 ATPase

Human ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. Increased plasma membrane abundance of PMCA4b in vemurafenib-treated BRAF (show BRAF Proteins) mutant cells is associated with enhanced Ca2 (show CA2 Proteins)+ clearance.

  2. The role of heterozygous variants of ATP2B4 is regulated by HSPG2 (show HSPG2 Proteins) protein with transcription factors in bone formation through modulation of calcium signaling.

  3. RNA sequencing identified a novel ATPase, Ca2 (show CA2 Proteins)+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA (show PKCa Proteins)) fusion transcript.

  4. our data show that CD147 (show BSG Proteins) interacts via its immunomodulatory domains with PMCA4 to bypass TCR proximal signaling and inhibit IL-2 (show IL2 Proteins) expression.

  5. We also nominate a new candidate gene in congenital arrhythmia, ATP2B4, and provide experimental evidence of a regulatory role for variants discovered using this framework.

  6. p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of Familial spastic paraplegia

  7. The slowly activating PMCA4b isoform produced long-lasting Ca2 (show CA2 Proteins)+ oscillations in response to store-operated Ca2 (show CA2 Proteins)+ entry.

  8. While PMCA1b (show ATP2B1 Proteins) has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation.

  9. Mechanism of PMCA4 that creates lipid asymmetry is well understood in terms of ATP hydrolysis; molecular models exist for trajectory taken by phospholipid substrates through the enzyme. [review-like article]

  10. Calcium dysregulation resulting from a novel missense mutation (c.803G>A, p.R268Q) in the PMCA4 (ATP2B4) gene may be associated with the pathogenesis of familial spastic paraplegia.

Mouse (Murine) ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4) interaction partners

  1. PMCA4 has no discernible role in normal renal Ca2 (show CA2 Proteins)+ handling as no urinary Ca2 (show CA2 Proteins)+ wasting was observed. Further investigation of the exact role of PMCA4 in the distal convoluted tubule and connecting tubule is required

  2. PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition.

  3. Electron microscopy demonstrated Pmca4 localization in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments but not submembranous vesicles

  4. Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (show ATP2B2 Proteins) (PMCA) by Homer2 (show HOMER2 Proteins) protein that has a central role on PMCA-mediated Ca(2 (show CA2 Proteins)+) signaling in parotid acinar cells.

  5. PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis.

  6. this study concludes that Ca(2 (show CA2 Proteins)+) efflux activity of PMCA4 underlies G1 progression in vascular smooth muscle cells and that PMCA4a and PMCA4b differentially regulate specific downstream mediators.

  7. Ca(2 (show CA2 Proteins)+) homeostasis in sperm is maintained by the relative ratios of CASK (show CASK Proteins)-PMCA4b and CASK (show CASK Proteins)-JAM-A (show F11R Proteins) interactions

  8. Plasma membrane calcium pump (show ATP2B2 Proteins) (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2 (show ATP2B2 Proteins).

  9. Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase (show NOS1 Proteins) complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

  10. expression of Atp2b4 significantly decreased in enamel organs from Mmp20 (show MMP20 Proteins)(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.

ATP2B4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with ATP2B4

  • ATPase, Ca++ transporting, plasma membrane 4 (ATP2B4)
  • ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2)
  • ATPase, Ca++ transporting, plasma membrane 4 (atp2b4)
  • ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4)
  • ATP2B1 protein
  • atp2b2 protein
  • atp2b3 protein
  • ATP2B4 protein
  • mxra1 protein
  • Pmca4 protein
  • pmca4b protein
  • pmca4x protein
  • zgc:152801 protein

Protein level used designations for ATP2B4

plasma membrane calcium ATPase 4 , plasma membrane calcium-transporting ATPase 4 , ATPase, Ca++ transporting, plasma membrane 4 , plasma membrane calcium-transporting ATPase 2 , plasma membrane calcium-transporting ATPase 4-like , matrix-remodeling-associated protein 1 , sarcolemmal calcium pump , plasma membrane Ca2+-ATPases 4 , plasma membrane calcium ATPase , plasma membrane calcium pump , pmca4 , ATPase, Ca++ transporting, plasma membrane 3 , plasma membrane calcium ATPase 3 , ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1

457646 Pan troglodytes
574317 Macaca mulatta
613800 Bos taurus
100049920 Equus caballus
100410901 Callithrix jacchus
100089144 Ornithorhynchus anatinus
100446010 Pongo abelii
100558540 Anolis carolinensis
100603540 Nomascus leucogenys
493 Homo sapiens
733701 Sus scrofa
29600 Rattus norvegicus
768304 Danio rerio
446855 Xenopus laevis
419934 Gallus gallus
403731 Canis lupus familiaris
282146 Bos taurus
100353865 Oryctolagus cuniculus
381290 Mus musculus
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