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Browse our DPYD Proteins (DPYD)

Full name:
Dihydropyrimidine Dehydrogenase Proteins (DPYD)
On are 7 Dihydropyrimidine Dehydrogenase (DPYD) Proteins from 4 different suppliers available. Additionally we are shipping DPYD Antibodies (54) and DPYD Kits (36) and many more products for this protein. A total of 99 DPYD products are currently listed.
14.t00017, AI315208, DDBDRAFT_0189681, DDBDRAFT_0231100, DDB_0189681, DDB_0231100, DHP, DHPDHASE, DPD, dpyd, E330028L06Rik, zgc:77205
list all proteins Gene Name GeneID UniProt
Rat DPYD DPYD 81656 O89000
DPYD 1806 Q12882
DPYD 99586 Q8CHR6

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DPYD Proteins (DPYD) by Origin

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More Proteins for DPYD Interaction Partners

Human Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

  1. ERCC1 (show ERCC1 Proteins)-SNP in combination with mRNA ERCC1 (show ERCC1 Proteins), DPYD, and ERBB2 (show ERBB2 Proteins) from pretherapeutic endoscopic biopsies can predict minor response to chemoradiation, as a basis for individualized therapy of advanced esophageal cancer.

  2. Fourteen out of 275 cancer patients (5.1%) carried a DPYD variant and received a 25-50% dose reduction recommendation for 5-fluorouracil or capecitabine. None of the patients with a DPYD variant treated with a reduced dose developed toxicities.

  3. findings showed that almost 57.1% of Chinese colorectal cancer patients had at least one variant of DPYD*5A and DPYD*9A

  4. High levels of intratumoral DPD expression have a negative impact on sensitivity to 5-fluorouracil in gastric cancer patients, but no prognostic value for long-term survival was uncovered. (Meta-analysis)

  5. Reprot strong functional effect of a DPYD haplotype upon a phenotypic marker of individual 5-FU metabolism to improve toxicity prediction.

  6. we believe that developing functional testing at the bedside could probably help to better picture the actual DPD status of patients scheduled for fluorouracil-based therapy, so as to propose subsequent appropriate adaptive dosing strategies.

  7. DPYD genotyping for alleles 7, *2A, *13 and Y186C was not helpful in the identification of patients with severe DPD deficiency in this series of patients

  8. Our results revealed that the C allele of the DPYD 85T > C polymorphism might be associated with susceptibility to pediatric acute lymphoblastic leukemia

  9. Increases in gene expression levels of TYMP (show TYMP Proteins), DPYD, and HIF1A (show HIF1A Proteins) in tumor tissues at 7 days after the start of CRT (show SLC6A8 Proteins) may be useful for predicting the efficacy of CRT (show SLC6A8 Proteins) including S-1 or UFT

  10. There were not statistical significant differences between carriers of KRAS mutated alleles between SD and PD groups. No significant difference was found between response rates and toxicity and DPD or UGT1A1 (show UGT1A1 Proteins) genotypes. Our results suggested that determination of DPD or UGT1A1 (show UGT1A1 Proteins) genotypes could not be useful for predicting severe toxicity of irinotecan in our population.

Mouse (Murine) Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

  1. DPD gene expression is regulated first at the mRNA level when the hepatocytes enter the cell cycle. There is little regulation at the translational level. Cell proliferation rate is influences the enzyme activity modification.

Pig (Porcine) Dihydropyrimidine Dehydrogenase (DPYD) interaction partners

  1. Data show that dihydropyrimidine dehydrogenase residue H673 is required for active site closure, while S670 is important for substrate recognition.

DPYD Protein Profile

Protein Summary

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with DPYD

  • dihydropyrimidine dehydrogenase (DPYD)
  • dihydropyrimidine dehydrogenase b (dpydb)
  • dihydropyrimidine dehydrogenase (dpyd)
  • dihydropyrimidine dehydrogenase (EHI_012980)
  • dihydropyrimidine dehydrogenase (AaeL_AAEL014199)
  • dihydropyrimidine dehydrogenase (AaeL_AAEL010204)
  • dihydropyrimidine dehydrogenase (EDI_044620)
  • dihydropyrimidine dehydrogenase (pyd1)
  • dihydropyrimidine dehydrogenase (Dpyd)
  • dihydropyrimidine dehydrogenase (LOC100356889)
  • 14.t00017 protein
  • AI315208 protein
  • DDBDRAFT_0189681 protein
  • DDBDRAFT_0231100 protein
  • DDB_0189681 protein
  • DDB_0231100 protein
  • DHP protein
  • DHPDHASE protein
  • DPD protein
  • dpyd protein
  • E330028L06Rik protein
  • zgc:77205 protein

Protein level used designations for DPYD

DHPDHase , DPD , dihydropyrimidine dehydrogenase [NADP(+)] , dihydrothymine dehydrogenase , dihydrouracil dehydrogenase , dihydropyrimidine dehydrogenase

100173131 Pongo abelii
457047 Pan troglodytes
715672 Macaca mulatta
100057177 Equus caballus
405829 Danio rerio
447312 Xenopus laevis
3410647 Entamoeba histolytica HM-1:IMSS
5563876 Aedes aegypti
5573038 Aedes aegypti
5882869 Entamoeba dispar SAW760
8616259 Dictyostelium discoideum AX4
100604410 Nomascus leucogenys
81656 Rattus norvegicus
1806 Homo sapiens
99586 Mus musculus
100727906 Cavia porcellus
397109 Sus scrofa
281124 Bos taurus
479935 Canis lupus familiaris
429083 Gallus gallus
101109311 Ovis aries
100356889 Oryctolagus cuniculus
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