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accumulation of RX-3117 nucleotides correlated with UCK2 expression.
UCK1 (show CKLF Antibodies) and 2 are both expressed in several neuroblastoma (show ARHGEF16 Antibodies) cell lines, including four MYCN (show MYCN Antibodies) single copy cell lines and five MYCN (show MYCN Antibodies) amplified cell lines
Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.
Increased intranuclear levels of UK may contribute to the metabolic build-up that is needed for Epstein-Barr virus nuclear protein (show RDBP Antibodies) EBNA-3 (show EBNA-3A Antibodies)-mediated B-cell blast transformation and rapid proliferation.
UCK2 is responsible for phosphorylation and activation of the antitumor activity of 3'-ethynyl nucleosides 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine and 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine.
B4GALT3 (show B4GALT3 Antibodies), DAP3 (show DAP3 Antibodies), RGS16 (show RGS16 Antibodies), TMEM183A and UCK2--were significantly overexpressed in dup (show MSH3 Antibodies)(1q)-positive ALLs compared with high hyperdiploid ALLs without dup (show MSH3 Antibodies)(1q).
The mechanism of phosphate transfer in UCK2 is shown to be concerted, and is accompanied by concerted proton transfer from the 5'-hydroxyl to a conserved active site aspartic acid that serves as a catalytic base
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 126.96.36.199) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.
, cytidine monophosphokinase 2-B
, uridine monophosphokinase 2-B
, uridine-cytidine kinase 2
, uridine-cytidine kinase 2-B
, uridine phosphokinase
, uridine kinase
, Uridine kinase
, UCK 2
, cytidine monophosphokinase 2
, uridine monophosphokinase 2
, toxin secretion ABC transporter ATP-binding protein
, testis-specific protein TSA903
, uridine monophosphate kinase
, uridine monophosphate kinase 2