Browse our anti-DDR2 (DDR2) Antibodies

Full name:
anti-Discoidin Domain Receptor tyrosine Kinase 2 Antibodies (DDR2)
On are 115 Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antibodies from 20 different suppliers available. Additionally we are shipping DDR2 Proteins (31) and DDR2 Kits (11) and many more products for this protein. A total of 171 DDR2 products are currently listed.
AW495251, ddr2, MIG20a, NTRKR3, si:ch211-193c2.1, TKT, Tyro10
list all antibodies Gene Name GeneID UniProt
DDR2 18214 Q62371
DDR2 4921 Q16832
DDR2 685781  

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anti-Mouse (Murine) DDR2 Antibodies:

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anti-Rat (Rattus) DDR2 Antibodies:

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Top referenced anti-DDR2 Antibodies

  1. Human Polyclonal DDR2 Primary Antibody for WB - ABIN392068 : Vogel, Gish, Alves, Pawson: The discoidin domain receptor tyrosine kinases are activated by collagen. in Molecular cell 1998 (PubMed)
    Show all 5 references for 392068

  2. Human Polyclonal DDR2 Primary Antibody for EIA, WB - ABIN359957 : Edelhoff, Sweetser, Disteche: Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. in Genomics 1995 (PubMed)
    Show all 5 references for 359957

  3. Human Polyclonal DDR2 Primary Antibody for EIA, WB - ABIN359956 : Karn, Holtrich, Bräuninger, Böhme, Wolf, Rübsamen-Waigmann, Strebhardt: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. in Oncogene 1993 (PubMed)
    Show all 5 references for 359956

  4. Human Monoclonal DDR2 Primary Antibody for ICC, IHC - ABIN969083 : Leitinger, Kwan: The discoidin domain receptor DDR2 is a receptor for type X collagen. in Matrix biology : journal of the International Society for Matrix Biology 2006 (PubMed)
    Show all 3 references for 969083

  5. Human Polyclonal DDR2 Primary Antibody for IF (p), IHC (p) - ABIN755218 : Wang, Wang, Zhao, Li, Deng: Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. in Biochemical pharmacology 2013 (PubMed)
    Show all 2 references for 755218

  6. Mouse (Murine) Polyclonal DDR2 Primary Antibody for ELISA, IHC (p) - ABIN2001101 : Zhang, Ding, Zhang, Su, Li, Liu, Ma, Yao: Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. in Molecular and cellular biochemistry 2006 (PubMed)
    Show all 2 references for 2001101

More Antibodies against DDR2 Interaction Partners

Mouse (Murine) Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) interaction partners

  1. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13 (show MMP13 Antibodies).

  2. DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

  3. Study showed that Nrp1 (show NRP1 Antibodies) expression paralleled with that of DDR2 during osteoblast differentiation. Nrp1 (show NRP1 Antibodies) assisted the promoting role of DDR2 in osteoblast differentiation, via activation of DDR2-mediated downstream signaling.

  4. Data show that discoidin domain receptor (DDR (show DDR1 Antibodies)) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 (show MAPK3 Antibodies) and 2 and nuclear factor of kappa B (NF-kappaB (show NFKB1 Antibodies)) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 (show MMP2 Antibodies) and 9.

  5. RESULTS Data show that DDR2 (discoidin domain receptor 2) suppresses osteoclast differentiation and activity.

  6. DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review]

  7. Germline deletion of the DDR2 results in smaller hearts, shorter cardiomyocytes, lower interstitial cardiac collagen density and abnormalities in cardiac function.

  8. Taken together, our data demonstrated that DDR2 might play a systemic role in the regulation of body size thorough skeletal formation and fat metabolism.

  9. Loss of DDR2 suppresses tumor angiogenesis and tumor metastasis to the lung.

  10. DDR2 is involved in the collagen I-induced IL-12 (show IL12A Antibodies) production via NF-kappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies) pathway

Human Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) interaction partners

  1. The group of patients with colorectal cancer with high DDR2 expression had significantly higher frequencies of T4, lymph node metastasis, and peritoneal dissemination compared to the group with low DDR2 expression.

  2. DDR2 showed high expression in gastric cancer tissues and cells. In xenograft models, DDR2 overexpression promoted tumor formation. Furthermore, DDR2 expression impacted on the invasion and motility of GC cells, accompanied by changes in EMT (show ITK Antibodies) marker expression. Finally, our results revealed that DDR2 facilitates GC cell invasion and EMT (show ITK Antibodies) through mTORC2 (show CRTC2 Antibodies) activation and AKT (show AKT1 Antibodies) phosphorylation.

  3. DDR2 mediates collagen-induced activation of MT1-MMP (show MMP14 Antibodies) in human fibroblasts

  4. Study strongly suggests that during pulmonary fibrosis, DDR2 not only participates in both the initiation and maintenance of fibrotic reaction, but also affects both ECM (show MMRN1 Antibodies) production and angiogenesis.

  5. signaling pathway, effectively suppressed peritoneal dissemination. DDR2 was identified as a driver gene for Gastric Cancer dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting Gastric Cancer peritoneal dissemination.

  6. Ang II (show AGT Antibodies) induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 MAPK (show MAPK14 Antibodies)-mediated activation of NF-kappaB (show NFKB1 Antibodies).

  7. DDR2 Missense mutation is associated with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type.

  8. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl (show KRT7 Antibodies)-like proteins that inhibit collagen-DDR (show DDR1 Antibodies) interactions and macrophage migration.

  9. DDR2 plays an important role in promoting hepatocellular carcinoma cell invasion and migration by stabilizing SNA1 (show SNAI1 Antibodies).

  10. The inhibition of DDR2 by RNA interference suppressed in vivo and in vitro growth of human hepatocellular carcinoma cells.

DDR2 Antigen Profile

Antigen Summary

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with DDR2

  • discoidin domain receptor tyrosine kinase 2 (DDR2) antibody
  • discoidin domain receptor family, member 2b (ddr2b) antibody
  • discoidin domain receptor family, member 2 (LOC100356982) antibody
  • discoidin domain receptor family, member 2 (Ddr2) antibody
  • discoidin domain receptor tyrosine kinase 2 (Ddr2) antibody
  • AW495251 antibody
  • ddr2 antibody
  • MIG20a antibody
  • NTRKR3 antibody
  • si:ch211-193c2.1 antibody
  • TKT antibody
  • Tyro10 antibody

Protein level used designations for DDR2

discoidin domain receptor tyrosine kinase 2 , discoidin domain receptor family, member 2 , CD167 antigen-like family member B , discoidin domain receptor 2 , discoidin domain-containing receptor 2 , neurotrophic tyrosine kinase, receptor-related 3 , receptor protein-tyrosine kinase TKT , tyrosine-protein kinase TYRO10 , cell migration-inducing protein 20 , discoidin domain-containing receptor tyrosine kinase 2 , hydroxyaryl-protein kinase , migration-inducing gene 16 protein , neurotrophic tyrosine kinase receptor related 3 , tyrosylprotein kinase , CD167b antigen , tyrosine-protein kinase TYRO 10

457467 Pan troglodytes
565333 Danio rerio
100356982 Oryctolagus cuniculus
18214 Mus musculus
4921 Homo sapiens
685781 Rattus norvegicus
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