Browse our DDR2 Proteins (DDR2)

Full name:
Discoidin Domain Receptor tyrosine Kinase 2 Proteins (DDR2)
On are 33 Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Proteins from 10 different suppliers available. Additionally we are shipping DDR2 Antibodies (116) and DDR2 Kits (11) and many more products for this protein. A total of 174 DDR2 products are currently listed.
AW495251, ddr2, MIG20a, NTRKR3, si:ch211-193c2.1, TKT, Tyro10
list all proteins Gene Name GeneID UniProt
DDR2 18214 Q62371
DDR2 4921 Q16832
DDR2 685781  

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DDR2 Proteins (DDR2) by Origin

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Top referenced DDR2 Proteins

  1. Rat (Rattus) DDR2 Protein expressed in Human Cells - ABIN2009515 : Alves, Vogel, Mossie, Millauer, Höfler, Ullrich: Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. in Oncogene 1995 (PubMed)
    Show all 4 references for 2009515

  2. Human DDR2 Protein expressed in Human Cells - ABIN2002356 : Leitinger, Kwan: The discoidin domain receptor DDR2 is a receptor for type X collagen. in Matrix biology : journal of the International Society for Matrix Biology 2006 (PubMed)
    Show all 4 references for 2002356

  3. Rhesus Monkey DDR2 Protein expressed in Human Cells - ABIN2010022 : Wall, Werner, Werb, DeClerck: Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. in The Journal of biological chemistry 2005 (PubMed)
    Show all 4 references for 2010022

  4. Rat (Rattus) DDR2 Protein expressed in Human Cells - ABIN2009512 : Ferri, Carragher, Raines: Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. in The American journal of pathology 2004 (PubMed)
    Show all 4 references for 2009512

  5. Rhesus Monkey DDR2 Protein expressed in HEK-293 Cells - ABIN2180957 : Gibbs, Rogers, Katze, Bumgarner, Weinstock, Mardis, Remington, Strausberg, Venter, Wilson, Batzer, Bustamante, Eichler, Hahn, Hardison, Makova, Miller, Milosavljevic, Palermo, Siepel, Sikela, Attaway et al.: Evolutionary and biomedical insights from the rhesus macaque genome. ... in Science (New York, N.Y.) 2007 (PubMed)
    Show all 3 references for 2180957

More Proteins for DDR2 Interaction Partners

Mouse (Murine) Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) interaction partners

  1. circulating fibroblast precursors expressing DDR2, in an exposure-induced model of pulmonary fibrosis, is reported.

  2. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.

  3. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13 (show MMP13 Proteins).

  4. DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

  5. Study showed that Nrp1 (show NRP1 Proteins) expression paralleled with that of DDR2 during osteoblast differentiation. Nrp1 (show NRP1 Proteins) assisted the promoting role of DDR2 in osteoblast differentiation, via activation of DDR2-mediated downstream signaling.

  6. Data show that discoidin domain receptor (DDR (show DDR1 Proteins)) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 (show MAPK3 Proteins) and 2 and nuclear factor of kappa B (NF-kappaB (show NFKB1 Proteins)) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 (show MMP2 Proteins) and 9.

  7. RESULTS Data show that DDR2 (discoidin domain receptor 2) suppresses osteoclast differentiation and activity.

  8. DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review]

  9. Germline deletion of the DDR2 results in smaller hearts, shorter cardiomyocytes, lower interstitial cardiac collagen density and abnormalities in cardiac function.

  10. Taken together, our data demonstrated that DDR2 might play a systemic role in the regulation of body size thorough skeletal formation and fat metabolism.

Human Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) interaction partners

  1. This study suggested that DDR1 (show DDR1 Proteins) and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (show TREM2 Proteins) and microglia.

  2. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.

  3. The group of patients with colorectal cancer with high DDR2 expression had significantly higher frequencies of T4, lymph node metastasis, and peritoneal dissemination compared to the group with low DDR2 expression.

  4. DDR2 showed high expression in gastric cancer tissues and cells. In xenograft models, DDR2 overexpression promoted tumor formation. Furthermore, DDR2 expression impacted on the invasion and motility of GC cells, accompanied by changes in EMT (show ITK Proteins) marker expression. Finally, our results revealed that DDR2 facilitates GC cell invasion and EMT (show ITK Proteins) through mTORC2 (show CRTC2 Proteins) activation and AKT (show AKT1 Proteins) phosphorylation.

  5. DDR2 mediates collagen-induced activation of MT1-MMP (show MMP14 Proteins) in human fibroblasts

  6. Study strongly suggests that during pulmonary fibrosis, DDR2 not only participates in both the initiation and maintenance of fibrotic reaction, but also affects both ECM (show MMRN1 Proteins) production and angiogenesis.

  7. signaling pathway, effectively suppressed peritoneal dissemination. DDR2 was identified as a driver gene for Gastric Cancer dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting Gastric Cancer peritoneal dissemination.

  8. Ang II (show AGT Proteins) induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 MAPK (show MAPK14 Proteins)-mediated activation of NF-kappaB (show NFKB1 Proteins).

  9. DDR2 Missense mutation is associated with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type.

  10. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl (show KRT7 Proteins)-like proteins that inhibit collagen-DDR (show DDR1 Proteins) interactions and macrophage migration.

DDR2 Protein Profile

Protein Summary

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with DDR2

  • discoidin domain receptor tyrosine kinase 2 (DDR2)
  • discoidin domain receptor family, member 2b (ddr2b)
  • discoidin domain receptor family, member 2 (LOC100356982)
  • discoidin domain receptor family, member 2 (Ddr2)
  • discoidin domain receptor tyrosine kinase 2 (Ddr2)
  • AW495251 protein
  • ddr2 protein
  • MIG20a protein
  • NTRKR3 protein
  • si:ch211-193c2.1 protein
  • TKT protein
  • Tyro10 protein

Protein level used designations for DDR2

discoidin domain receptor tyrosine kinase 2 , discoidin domain receptor family, member 2 , CD167 antigen-like family member B , discoidin domain receptor 2 , discoidin domain-containing receptor 2 , neurotrophic tyrosine kinase, receptor-related 3 , receptor protein-tyrosine kinase TKT , tyrosine-protein kinase TYRO10 , cell migration-inducing protein 20 , discoidin domain-containing receptor tyrosine kinase 2 , hydroxyaryl-protein kinase , migration-inducing gene 16 protein , neurotrophic tyrosine kinase receptor related 3 , tyrosylprotein kinase , CD167b antigen , tyrosine-protein kinase TYRO 10

457467 Pan troglodytes
565333 Danio rerio
100356982 Oryctolagus cuniculus
18214 Mus musculus
4921 Homo sapiens
685781 Rattus norvegicus
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