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It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 (show ADAM10 ELISA Kits) and flotillin-1 (show FLOT1 ELISA Kits).
During urogenital development, different modes of Eph (show EPHA1 ELISA Kits)/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.
Male Efnb2 knockout mice presented reduced blood pressure. Region from aa 313 to aa 331 of EFNB2 was essential for reverse signaling regulating VSMC contractility.
Suggest role for ephrinB2/EphB4 (show EPHB4 ELISA Kits) signaling in the maintenance of neurovascular homeostasis and show that EphrinB2 activation promotes vascular repair mechanisms and reduces brain swelling after mild cerebral ischemia.
The Eph (show EPHA1 ELISA Kits)/ephrin-B2-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.
Control of abscission requires Eph (show EPHA1 ELISA Kits) kinase activity, and Src (show SRC ELISA Kits) and citron kinase (show CIT ELISA Kits) (CitK) are downstream effectors in the Eph (show EPHA1 ELISA Kits)-induced signal transduction cascade
The Netrin-1 (show NTN1 ELISA Kits) and ephrin-B2 synergistic growth cone responses involve the potentiation of Src (show SRC ELISA Kits) family kinase signaling, a common effector of both pathways.
in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development
the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.
our study uncovered a novel cell autonomous role for ephrinB2 in lateral motor column motoneurons
These data indicate that ephrinB2/EphB4 (show EPHB4 ELISA Kits) signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.
High EFNB2 expression is associated with preeclampsia.
Inhibition of EphB4 (show EPHB4 ELISA Kits) forward signaling using soluble EphB4 (show EPHB4 ELISA Kits) protein fused (show AXIN1 ELISA Kits) with murine serum albumin (show ALB ELISA Kits) failed to affect eRMS model tumor progression, but did moderately slow progression in murine aRMS
Study shows that EFNB2 is overexpressed in head and neck squamous cell carcinoma, pancreatic adenocarcinoma, and urothelial bladder carcinoma, and its overexpression correlates with poor survival of the cancer patients.
Five SNPs in the 3' region of the EFNB2 were in linkage disequilibrium and significantly associated with hypertension for male but not female subjects.
These results indicate a novel mechanism of ephrin-Eph (show EPHA1 ELISA Kits) signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2 (show EPHB2 ELISA Kits)(+)extracellular vesicles in neural development and synapse physiology.
Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
miR (show MLXIP ELISA Kits)-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR (show MLXIP ELISA Kits)-137, as a risk factor for schizophrenia
5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src (show SRC ELISA Kits)-ERK (show EPHB2 ELISA Kits) pathway, and drives EMT (show ITK ELISA Kits) via the Src (show SRC ELISA Kits)-FAK (show PTK2 ELISA Kits) pathway.
Together, these findings suggest that CCL2 (show CCL2 ELISA Kits), RARRES2 (show RARRES2 ELISA Kits) and EFNB2 are host cell factors involved in respiratory syncytial virus replication.
These genes may be potential biomarkers for identification of subclinical lymph node involvement in papillary thyroid carcinoma (PTC (show F9 ELISA Kits))
The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
, ephrin-B2 precursor
, ephrin B2
, EPH-related receptor tyrosine kinase ligand 5
, HTK ligand
, eph-related receptor tyrosine kinase ligand 5
, ligand of eph-related kinase 5