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It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 (show ADAM10 ELISA Kits) and flotillin-1 (show FLOT1 ELISA Kits).
The Netrin-1 (show NTN1 ELISA Kits) and ephrin-B2 synergistic growth cone responses involve the potentiation of Src (show SRC ELISA Kits) family kinase signaling, a common effector of both pathways.
in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development
the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.
our study uncovered a novel cell autonomous role for ephrinB2 in lateral motor column motoneurons
These data indicate that ephrinB2/EphB4 (show EPHB4 ELISA Kits) signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.
EfnB2 is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EfnB2 signaling repressing JNK3 (show MAPK10 ELISA Kits) activity via STAT1 (show STAT1 ELISA Kits).
disruption of cochlear signalling results in supporting cell (show PTPRJ ELISA Kits) translocation into hair cell layers
Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.
Mice bearing genetically altered cytoplasmic region of ephrinB2 have significantly altered EphB4 (show EPHB4 ELISA Kits)-dependent forward signaling.
Conditioned deletion of ephrinB1 (show EFNB1 ELISA Kits) and/or ephrinB2 in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts.
Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
miR (show MLXIP ELISA Kits)-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR (show MLXIP ELISA Kits)-137, as a risk factor for schizophrenia
5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src (show SRC ELISA Kits)-ERK (show EPHB2 ELISA Kits) pathway, and drives EMT (show ITK ELISA Kits) via the Src (show SRC ELISA Kits)-FAK (show PTK2 ELISA Kits) pathway.
Together, these findings suggest that CCL2 (show CCL2 ELISA Kits), RARRES2 (show RARRES2 ELISA Kits) and EFNB2 are host cell factors involved in respiratory syncytial virus replication.
These genes may be potential biomarkers for identification of subclinical lymph node involvement in papillary thyroid carcinoma (PTC (show F9 ELISA Kits))
Results suggest a potential signalling hierarchy between Delta-like 1 (show DLL1 ELISA Kits) and ephrin-B2 ligands, as neural stem cells adopt the Delta-like 1 (show DLL1 ELISA Kits) phenotype of stem cell maintenance on simultaneous presentation of both signals.
Results suggest that ephrinB2 may function as a colorectal cancer cells growth stimulator.
Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus.
Data suggest that fusion of Nipah viruses with host cells is facilitated by two of viral membrane proteins, the G protein and the F protein (show HPD ELISA Kits); G head domain binds to human ephrins B2 and B3 altering conformational density of entire G head domain.
The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
, ephrin-B2 precursor
, ephrin B2
, EPH-related receptor tyrosine kinase ligand 5
, HTK ligand
, eph-related receptor tyrosine kinase ligand 5
, ligand of eph-related kinase 5