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Browse our FGF2 Proteins (FGF2)

Full name:
Fibroblast Growth Factor 2 (Basic) Proteins (FGF2)
On are 182 Fibroblast Growth Factor 2 (Basic) (FGF2) Proteins from 24 different suppliers available. Additionally we are shipping FGF2 Antibodies (358) and FGF2 Kits (85) and many more products for this protein. A total of 636 FGF2 products are currently listed.
list all proteins Gene Name GeneID UniProt
FGF2 14173 P15655
FGF2 54250 P13109
FGF2 2247 P09038

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FGF2 Proteins (FGF2) by Origin

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Top referenced FGF2 Proteins

  1. Mouse (Murine) FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2667409 : Chiou, Xu, Longaker: Mitogenic and chondrogenic effects of fibroblast growth factor-2 in adipose-derived mesenchymal cells. in Biochemical and biophysical research communications 2006 (PubMed)
    Show all 5 references for ABIN2667409

  2. Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2667407 : Cronauer, Schulz, Seifert, Ackermann, Burchardt: Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications. in European urology 2003 (PubMed)
    Show all 5 references for ABIN2667407

  3. Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2001904 : Wied?ocha, Falnes, Madshus, Sandvig, Olsnes: Dual mode of signal transduction by externally added acidic fibroblast growth factor. in Cell 1994 (PubMed)
    Show all 5 references for ABIN2001904

  4. Mouse (Murine) FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2007208 : Orpana, Salven: Angiogenic and lymphangiogenic molecules in hematological malignancies. in Leukemia & lymphoma 2002 (PubMed)
    Show all 4 references for ABIN2007208

  5. Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN666716 : Eriksson, Cousens, Weaver, Matthews: Three-dimensional structure of human basic fibroblast growth factor. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 references for ABIN666716

  6. Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413246 : Matsukura, Muneta, Tsuji, Miyatake, Yamada, Abula, Koga, Tomita, Sekiya: Mouse synovial mesenchymal stem cells increase in yield with knee inflammation. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014 (PubMed)

More Proteins for FGF2 Interaction Partners

Mouse (Murine) Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. In vivo, GSPP treatment (200 mg/kg/d) not only inhibited the growth of colon carcinoma, but also inhibited the tumor lymphangiogenesis. Conclusion. GSPP possesses the antitumor ability by inhibiting bFGF-inducing lymphangiogenesis in vitro and in vivo, which may further inhibit tumor lymphatic metastasis.

  2. The present study indicates that a broad array of genes associated with functions of the cytoskeleton is significantly dysregulated in the MSC (show MSC Proteins) cortex of FGF-2 knockout mice

  3. SCN2B (show SCN2B Proteins) could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A (show COX5A Proteins) and FGF-2.

  4. Lack of fibroblast growth factor-2 results in an increased volume of the striatal target area in mice.

  5. Low RICTOR expression was detected in quiescent, confluent mouse aortic endothelial cells, whereas high doses of FGF2 induced high RICTOR expression that was associated with strong mTORC2 (show CRTC2 Proteins)-specific protein kinase (show CDK7 Proteins) Ca and AKT (show AKT1 Proteins) phosphorylation

  6. Endogenous FGF2 secreted by trophoectoderm cells regulates protein expression and distribution in trophectoderm cells via FGFR2 (show FGFR2 Proteins).

  7. IL-1beta (show IL1B Proteins) promotes FGF-2 expression in chondrocytes

  8. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin (show CRYAA Proteins) both directly and indirectly via up-regulation of c-Maf (show MAF Proteins).

  9. FGF2 monoclonal antibody inhibited angiogenesis B16-F10 (show F10 Proteins) metastatic melanoma model.

  10. Findings demonstrate that Arf6 (show ARF6 Proteins) in neurons of the CNS plays an important role in oligodendrocyte precursor cells migration by regulating secretion of FGF-2 from neurons, thereby contributing to the axon myelination.

Zebrafish Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. Results uncover a novel Sdc2 (show SDC2 Proteins)-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis.

Cow (Bovine) Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. Data suggest THBS1 (thrombospondin-1 (show THBS1 Proteins)) expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1 (show THBS1 Proteins)/THBS2 (show THBS2 Proteins) but up-regulate expression of FGF2.

  2. Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA (show VEGFA Proteins) during these specific windows.

  3. FGF2 was crucial for luteal endothelial network formation.

  4. Associations between reproduction and milk traits, and polymorphisms at the STAT5A (show STAT5A Proteins) and FGF2 gene loci, were found with STAT5A (show STAT5A Proteins) polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).

  5. FGF2 and FGF10 (show FGF10 Proteins) regulate migratory activity of ovine trophoblast cells through MAPK (show MAPK1 Proteins)-dependent pathways.

  6. investigation of signaling mechanisms used by FGF2 to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through protein kinase C-delta (show PKCd Proteins)

  7. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  8. bFGF is oxidized by lysyl oxidase (show LOX Proteins)

  9. vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1 (show TGFB1 Proteins)) released by endothelial cells

  10. in luteolysis FGF-2 may participate in the suppression of cytokine-induced iNOS (show NOS2 Proteins) mRNA expression and in the prevention of an inflammatory reaction in the surrounding tissues.

Human Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. Study showed that both aFGF (show FGF1 Proteins) and bFGF were highly expressed in cervical cancer tissues. In tumors of higher clinical stages, the expression of these factors was further enhanced, suggesting that they play a role in facilitating cervical cancer cell proliferation.

  2. Silk scaffolds exhibit excellent cytocompatibility for human pre-adipose cells and have application potential in tissue engineering and regenerative medicine. VEGF and FGF-2 expressed on silk fibers could have a potential positive effect on pre-adipose cells, while the effect of VEGF should be further addressed in vivo.

  3. Study identifies 2 urinary biomarkers-bFGF and TIMP3 (show TIMP3 Proteins)-that successfully detect one of the most common pediatric brain tumors, juvenile pilocytic astrocytomas, with high accuracy

  4. targeting chemotherapy-induced FGF2 upregulation may provide a promising approach to manage the recurrence of superficial bladder cancer

  5. In vivo, GSPP treatment (200 mg/kg/d) not only inhibited the growth of colon carcinoma, but also inhibited the tumor lymphangiogenesis. Conclusion. GSPP possesses the antitumor ability by inhibiting bFGF-inducing lymphangiogenesis in vitro and in vivo, which may further inhibit tumor lymphatic metastasis.

  6. we used the esophageal cancer cell line ECA109 as a cell model and downregulated FGF2 expression using RNAi; the results showed that insufficient expression of FGF2 inhibited cells proliferation, migration, and invasion of ECA109 cells.

  7. RNA-seq analysis shows vast differences between the parent FGF2 grown, primed state cells, and NME7AB converted cells, but similarities to altered gene expression patterns reported by others generating naive-like stem cells via the use of biochemical inhibitors

  8. Our findings suggested that high plasma FGF2 level correlated with increased risk of obesity, and FGF2 gene polymorphisms could affect individual variances of obesity in Han Chinese population.

  9. FGF2 accelerated the fracture healing process due to its effects on factors that are important in chondrocyte and osteoblast differentiation and vascular invasion.

  10. A reduction in FGF-2 expression could contribute to age-related impaired function of human mesenchyme-derived progenitor cells via modulation of beta-catenin (show CTNNB1 Proteins) signaling via the FGFR1 (show FGFR1 Proteins) receptor.

Rabbit Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. Continuous passive motion can promote b-FGF expression to enhance type III collagen (show COL3A1 Proteins) synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits.

Pig (Porcine) Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 (show AKT1 Proteins) pathway.

  2. The overlapping relationships of 3'UTR ends between NUDT6 (show NUDT6 Proteins) and FGF-2 genes, were analyzed.

  3. FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.

  4. By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.

  5. qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.

  6. FGF2 activates FGFR (show FGFR2 Proteins) which then represses the fibroblast activation of valvular interstitial cells.

  7. FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins))-mediated myofibroblast activation

  8. upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar

Xenopus laevis Fibroblast Growth Factor 2 (Basic) (FGF2) interaction partners

  1. These results suggest that bFGF activation of neuronal FGFR1 (show FGFR1 Proteins) generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.

FGF2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

Alternative names and synonyms associated with FGF2

  • fibroblast growth factor 2 (Fgf2)
  • fibroblast growth factor 2 (fgf2)
  • fibroblast growth factor 2 (basic) (FGF2)
  • fibroblast growth factor 2 (basic) (Fgf2)
  • fibroblast growth factor 2 (basic) (fgf2)
  • BFGF protein
  • FGF-2 protein
  • FGFB protein
  • HBGF-2 protein

Protein level used designations for FGF2

HBGF-2 , basic fibroblast growth factor , heparin-binding growth factor 2 , BFGF , fibroblast growth factor 2 , basic fibroblast growth factor bFGF , prostatropin , Basic fibroblast growth factor , Heparin-binding growth factor 2

14173 Mus musculus
54250 Rattus norvegicus
404231 Danio rerio
281161 Bos taurus
2247 Homo sapiens
396413 Gallus gallus
100009068 Oryctolagus cuniculus
100721182 Cavia porcellus
397643 Sus scrofa
403857 Canis lupus familiaris
443306 Ovis aries
641462 Pan troglodytes
100101279 Xenopus laevis
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