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Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN803891
Robinson, Zhao, Rathjen, Rathjen, Hutchinson, Eyre, Hemsley, Hopwood: Embryonic stem cell-derived glial precursors as a vehicle for sulfamidase production in the MPS-IIIA mouse brain. in Cell transplantation 2010
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Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2721053
Li, Zuo, Jing, Ma, Wang, Liu, Zhu, Du, Xiong, Du, Xu, Xiao, Wang, Chai, Zhao, Deng: Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. in Cell stem cell 2015
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Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413246
Matsukura, Muneta, Tsuji, Miyatake, Yamada, Abula, Koga, Tomita, Sekiya: Mouse synovial mesenchymal stem cells increase in yield with knee inflammation. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014
Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2001904
Wied?ocha, Falnes, Madshus, Sandvig, Olsnes: Dual mode of signal transduction by externally added acidic fibroblast growth factor. in Cell 1994
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Human FGF2 Protein expressed in - ABIN621679
Guan, Guo, Yu, Wang, Wang, Konstantopoulos, Wang, Wang: The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. in Scientific reports 2015
Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2129216
Czekanska, Ralphs, Alini, Stoddart: Enhancing inflammatory and chemotactic signals to regulate bone regeneration. in European cells & materials 2014
Thus, FGF-2 levels in hESCs culture systems can be manipulated to generate cells with longer telomere which would be advantageous in the applications of hESCs in regenerative medicine.
Low FGF2 expression is associated with cardiac ischemia and systolic dysfunction.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Proteins), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Proteins), FGF-2 and PDGF (show PDGFA Proteins)-BB.
FGFR (show FGFR2 Proteins) Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt (show WNT2 Proteins) Signaling in FGF2 High Molecular Weight Isoform
data suggest that FGF2 levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 Proteins), FGFR2 (show FGFR2 Proteins), and FGFR3 (show FGFR3 Proteins).
The differentiation of ERF-overexpressing trophoblast stem cell lines also suggests that ERF may have an FGF2-independent effect during the commitment towards syncytiotrophoblasts.
Novel VF-Trap fusion protein on blockage of VEGF (show VEGFA Proteins) and FGF-2 activity to prevent angiogenesis.
FGF2 is an extracellular inducer of COUP-TFII (show NR2F2 Proteins) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 Proteins) expression prior to the onset of osteogenic differentiation
clearly demonstrate the different specificity of FGF12 (show FGF12 Proteins)-FGFR1c2 and FGF22 (show FGF22 Proteins)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
These results support that controlling the aberrant expression of TGF-beta1 (show TGFB1 Proteins) and FGF-2 via inhibition of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling could serve as a potential therapeutic strategy for pulmonary fibrosis.
Results uncover a novel Sdc2 (show SDC2 Proteins)-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis.
Taken together, Staphylococcus aureus induces TGF-beta1 (show TGFB1 Proteins) and bFGF expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.
Data suggest THBS1 (thrombospondin-1 (show THBS1 Proteins)) expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1 (show THBS1 Proteins)/THBS2 (show THBS2 Proteins) but up-regulate expression of FGF2.
Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA (show VEGFA Proteins) during these specific windows.
FGF2 was crucial for luteal endothelial network formation.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A (show STAT5A Proteins) and FGF2 gene loci, were found with STAT5A (show STAT5A Proteins) polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
FGF2 and FGF10 (show FGF10 Proteins) regulate migratory activity of ovine trophoblast cells through MAPK (show MAPK1 Proteins)-dependent pathways.
investigation of signaling mechanisms used by FGF2 to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through protein kinase C-delta (show PKCd Proteins)
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
bFGF is oxidized by lysyl oxidase (show LOX Proteins)
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1 (show TGFB1 Proteins)) released by endothelial cells
These observations identify airway smooth muscle cells -derived FGF2b as a factor needed for LMC formation by CD4 (show CD4 Proteins) T cells, affecting intercellular communication.
Report no relationship between serum bFGF levels and ovarian cancer microvessel density and tumor bFGF expression.
High FGF2 expression is associated with ovarian cancer.
The antitumor activity of scopoletin may be due to its strong anti-angiogenic effect, which may be mediated by its effective inhibition of ERK1 (show MAPK3 Proteins), VEGF-A (show VEGFA Proteins), and FGF-2.
TGF-beta (show TGFB1 Proteins), bFGF and epimorphin (show STX2 Proteins) in the extracellular microenvironment cooperatively affect HSF (show HSF1 Proteins) behaviors under the control of a highly sulfated (show SULF1 Proteins) chondroitin sulfate
High FGF2 expression is associated with lung cancer.
miR (show MLXIP Proteins)-205 enhances chemosensitivity of breast cancer cells to TAC (show IL2RA Proteins) docetaxol, doxorubicin plus cyclophosphamide) by suppressing both VEGFA (show VEGFA Proteins) and FGF2, leading to evasion of apoptosis.
analyses identified a new bFGF-regulating mechanism by which hedgehog (show SHH Proteins) signaling regulates human fibroblast migration; this data opens a new avenue for the wound healing therapy
results show that HMGA2 expression is associated with highly proliferating MSCs, is tightly regulated by FGF-2, and is involved in both proliferation and adipogenesis of Mesenchymal stem cells.
Continuous passive motion can promote b-FGF expression to enhance type III collagen (show COL3A1 Proteins) synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits.
Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 (show AKT1 Proteins) pathway.
The overlapping relationships of 3'UTR ends between NUDT6 (show NUDT6 Proteins) and FGF-2 genes, were analyzed.
FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.
By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.
qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.
FGF2 activates FGFR (show FGFR2 Proteins) which then represses the fibroblast activation of valvular interstitial cells.
FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins))-mediated myofibroblast activation
upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
These results suggest that bFGF activation of neuronal FGFR1 (show FGFR1 Proteins) generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
, basic fibroblast growth factor
, heparin-binding growth factor 2
, fibroblast growth factor 2
, basic fibroblast growth factor bFGF
, Basic fibroblast growth factor
, Heparin-binding growth factor 2