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Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2001904
Wied?ocha, Falnes, Madshus, Sandvig, Olsnes: Dual mode of signal transduction by externally added acidic fibroblast growth factor. in Cell 1994
Show all 5 references for ABIN2001904
Mouse (Murine) FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN2007208
Orpana, Salven: Angiogenic and lymphangiogenic molecules in hematological malignancies. in Leukemia & lymphoma 2002
Show all 4 references for ABIN2007208
Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN666716
Eriksson, Cousens, Weaver, Matthews: Three-dimensional structure of human basic fibroblast growth factor. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 references for ABIN666716
Human FGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413246
Matsukura, Muneta, Tsuji, Miyatake, Yamada, Abula, Koga, Tomita, Sekiya: Mouse synovial mesenchymal stem cells increase in yield with knee inflammation. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014
Endogenous FGF2 secreted by trophoectoderm cells regulates protein expression and distribution in trophectoderm cells via FGFR2 (show FGFR2 Proteins).
IL-1beta (show IL1B Proteins) promotes FGF-2 expression in chondrocytes
Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin (show CRYAA Proteins) both directly and indirectly via up-regulation of c-Maf (show MAF Proteins).
FGF2 monoclonal antibody inhibited angiogenesis B16-F10 metastatic melanoma model.
Findings demonstrate that Arf6 (show ARF6 Proteins) in neurons of the CNS plays an important role in oligodendrocyte precursor cells migration by regulating secretion of FGF-2 from neurons, thereby contributing to the axon myelination.
Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha (show PDGFRA Proteins).
These results demonstrated that recombinant human endostatin (show COL18A1 Proteins) could in-hibit tumor metastasis by inhibition of the expression of c-Myc (show MYC Proteins) and bFGF in gastric cancer tissue as well as by inhibition of angiogenesis
Cytosolic LMW FGF2 functions as a negative regulator in RIG-I (show DDX58 Proteins)-mediated antiviral signaling.
Data show that, depending of its concentration, FGF2 can be either a positive or negative factor of adipogenesis by regulating the ERK (show EPHB2 Proteins) signaling pathway providing a mechanistic basis for FGF2 roles in adipogenesis and development of fat tissues.
Trans-regulation of oligodendrocyte myelination by neurons through Arf6 (show ARF6 Proteins)-regulated secretion of fibroblast growth factor-2.
Results uncover a novel Sdc2 (show SDC2 Proteins)-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis.
Data suggest THBS1 (thrombospondin-1 (show THBS1 Proteins)) expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1 (show THBS1 Proteins)/THBS2 (show THBS2 Proteins) but up-regulate expression of FGF2.
Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA (show VEGFA Proteins) during these specific windows.
FGF2 was crucial for luteal endothelial network formation.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A (show STAT5A Proteins) and FGF2 gene loci, were found with STAT5A (show STAT5A Proteins) polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
FGF2 and FGF10 (show FGF10 Proteins) regulate migratory activity of ovine trophoblast cells through MAPK (show MAPK1 Proteins)-dependent pathways.
investigation of signaling mechanisms used by FGF2 to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through protein kinase C-delta (show PKCd Proteins)
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
bFGF is oxidized by lysyl oxidase (show LOX Proteins)
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1 (show TGFB1 Proteins)) released by endothelial cells
in luteolysis FGF-2 may participate in the suppression of cytokine-induced iNOS (show NOS2 Proteins) mRNA expression and in the prevention of an inflammatory reaction in the surrounding tissues.
FGF-2, VEGF-A (show VEGFA Proteins), and HIV-Tat (show TAT Proteins), may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A (show RHOA Proteins) and Src (show SRC Proteins) activity
FGF2 directly affects not only the biological properties of endothelial progenitor cells but also the expression pattern and secretion of numerous chemocytokines to regulate angiogenesis.
Serum CEA (show CEACAM5 Proteins), SCCA and bFGF joint detection improved detection sensitivity in lung cancer and had important reference value for pathological type deduction.
miR503 significantly decreased the migration and invasion ability of the osteosarcoma cells, which may be mediated by the inhibition of fibroblast growth factor 2.
BFGF overexpression is a potential indicator of worse prognosis for patients with operable non-small- and small- cell lung carcinomas. (Meta-analysis)
FGF2 monoclonal antibody inhibited angiogenesis in HUVEC cell cultures.
Expression of FGF-2, FGFR-2 (show FGFR2 Proteins) and FGFR-3 (show FGFR3 Proteins) was upregulated in patients with potentially malignant oral lesions serving as biomarkers of malignant transformation to oral squamous cell carcinoma.
FGF2 nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (show RAN Proteins) in human glioblastoma cells
ASC (show PYCARD Proteins) proliferation was enhanced by hypoxia. HIF-1a (show HIF1A Proteins) activation, FGF-2 production, and the ERK1/2 and Akt (show AKT1 Proteins) pathway were involved in this regulatory mechanism.
Continuous passive motion can promote b-FGF expression to enhance type III collagen (show COL3A1 Proteins) synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits.
Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 (show AKT1 Proteins) pathway.
The overlapping relationships of 3'UTR ends between NUDT6 (show NUDT6 Proteins) and FGF-2 genes, were analyzed.
FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.
By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.
qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.
FGF2 activates FGFR (show FGFR2 Proteins) which then represses the fibroblast activation of valvular interstitial cells.
FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins))-mediated myofibroblast activation
upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
These results suggest that bFGF activation of neuronal FGFR1 (show FGFR1 Proteins) generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
, basic fibroblast growth factor
, heparin-binding growth factor 2
, fibroblast growth factor 2
, basic fibroblast growth factor bFGF
, Basic fibroblast growth factor
, Heparin-binding growth factor 2