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Human FGF7 Protein expressed in Escherichia coli (E. coli) - ABIN2452198
Aaronson, Bottaro, Miki, Ron, Finch, Fleming, Ahn, Taylor, Rubin: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. in Annals of the New York Academy of Sciences 1992
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Human FGF7 Protein expressed in Human - ABIN2452199
Rubin, Osada, Finch, Taylor, Rudikoff, Aaronson: Purification and characterization of a newly identified growth factor specific for epithelial cells. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 2 Pubmed References
The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2 (show FGFR2 Proteins)).
Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression.
FGF7 stimulation of cell invasion and migration was partially suppressed by the FGFR2 (show FGFR2 Proteins) knockdown. In addition, FGF7/FGFR2 (show FGFR2 Proteins) upregulated THBS1 (show THBS1 Proteins), and cell invasion and migration were decreased by knockdown of THBS1 (show THBS1 Proteins)
Suppression of miR (show MLXIP Proteins)-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF.
This study evaluated the expression of FGF7, AhR (show AHR Proteins), and CYP1A1 (show CYP1A1 Proteins) in colorectal cancer cells and revealed a new mechanism by which KGF promotes cell proliferation through the AhR (show AHR Proteins)-cyclin D1 (show CCND1 Proteins) pathway in colon cancer cells.
KGF expression induced epithelial cell proliferation, reaching a peak level at day 4 and then decreased later, while in the long-term model, KGF expression in the EAC (show CYLD Proteins) led to middle ear cholesteatoma formation
In the current study, conditioned media and chemically defined media with recombinant human keratinocyte growth factor (KGF) could induce hUC (show ELAVL3 Proteins)-MSC (show MSC Proteins) differentiation into sweat gland-like cells (SGCs).
Coexpression of KGF and MMP-9 (show MMP9 Proteins) in gastric cancer could be a useful prognostic factor, and MMP-9 (show MMP9 Proteins) might also serve as a novel target for both prognostic prediction and therapeutics.
FGF7 over expression is associated with advanced clinical features in patients with upper tract and bladder urothelial carcinoma
Data indicate the key roles played, on the melanosome transfer in normal skin, by KGF/FGF7 released by dermal fibroblasts and by its receptor KGFR (show FGFR2 Proteins)/FGFR2b expressed and activated on the epidermal keratinocytes.
Subset of KGF-expressing respiratory epithelial cells may participate in a hitherto undescribed autocrine loop for stimulating KGF production in response to injury.
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7) and its receptor FGFR2IIIb (show FGFR2 Proteins)
This study investigates the relationships between progesterone, estradiol, and their receptors and the expression of FGF7 in the pig uterus in vivo.
Tregs express kgf. Treg-specific expression of kgf regulates alveolar epithelial proliferation during the resolution phase of acute lung injury and in a model of regenerative alveologenesis in vivo. AT2 (show AGTR2 Proteins) cells cocultured with Tregs lacking kgf have decreased rates of proliferation.
A role for endogenous KGF in maintenance of normal pulmonary innate immune function.
BMP4 (show BMP4 Proteins) promotes activation of FGF7 and FGF10 (show FGF10 Proteins) signaling, leading to an increase in proliferative basal cell population in developing skin.
we examine how the two presynaptic organizers FGF22 (show FGF22 Proteins) and FGF7 are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules.
Exendin-4 increased fibroblast growth factor 7 (Fgf7) expression in colonic polyps of Apc (show APC Proteins)(Min/+) mice.
Our observations also point towards PI3K acting as a morphogenic switch for FGF7 signalling.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
IL-19 (show IL19 Proteins) is important for cutaneous wound healing because it upregulates KGF expression.
FGF7 is downregulated in MED1 (show MBD4 Proteins)-deficient mesenchymal cells. FGF7 produced by mesenchymal stromal cells is a novel hematopoietic niche molecule.
FGF1 (show FGF1 Proteins) and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
FGF7 may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (show KITLG Proteins) signaling pathway.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Putative keratinocyte growth factor-like protein 2
, fibroblast growth factor 7 (keratinocyte growth factor)
, keratinocyte growth factor
, Keratinocyte growth factor
, heparin-binding growth factor 7
, fibroblast growth factor-7