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Browse our FGFR1 Proteins (FGFR1)

Full name:
Fibroblast Growth Factor Receptor 1 Proteins (FGFR1)
On are 47 Fibroblast Growth Factor Receptor 1 (FGFR1) Proteins from 16 different suppliers available. Additionally we are shipping FGFR1 Antibodies (599) and FGFR1 Kits (42) and many more products for this protein. A total of 736 FGFR1 products are currently listed.
ach, AW208770, bFGF-R-1, BFGFR, cb231, CD331, cd333, CEK, cek2, CG7223, CT22273, CT39172, DFGF-R1, DFGF-R2, Dfr-1, Dfr1, DFR1/DFGF-R2, Dmel\\CG7223, DmHD-38, DPR3, dtk1, DTRK(FR1), Eask, EMS2, FGF-R2, FGFBR, fgfr, Fgfr-1, fgfr-3, fgfr1, FGFR2, FGFRI, FLG, FLG-1, Flt-2, FLT2, Fr1, HBGFR, HD-38, HH2, hsfgfr3ex, Hspy, Htl, HTL/FGFR1, i79, i100, i150, j372, jtk4, KAL2, N-SAM, OGD, sb:cb231, Tk1, x1fgfr, XFGFR-1, xfgfr1, XFGFRA2
list all proteins Gene Name GeneID UniProt
FGFR1 2260 P11362
FGFR1 14182 P16092
FGFR1 79114 Q04589

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FGFR1 Proteins (FGFR1) by Origin

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Top referenced FGFR1 Proteins

  1. Mouse (Murine) FGFR1 Protein expressed in Human Cells - ABIN2007475 : Soker, Takashima, Miao, Neufeld, Klagsbrun: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. in Cell 1998 (PubMed)
    Show all 4 references for ABIN2007475

  2. Human FGFR1 Protein expressed in Human Cells - ABIN2003142 : Stauber, DiGabriele, Hendrickson: Structural interactions of fibroblast growth factor receptor with its ligands. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 4 references for ABIN2003142

  3. Cynomolgus FGFR1 Protein expressed in Human Cells - ABIN2009796 : Hunter, Kraft, Jacobs, Cox, Yeager, Hankinson, Wacholder, Wang, Welch, Hutchinson, Wang, Yu, Chatterjee, Orr, Willett, Colditz, Ziegler, Berg, Buys, McCarty, Feigelson, Calle, Thun, Hayes, Tucker et al.: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. ... in Nature genetics 2007 (PubMed)
    Show all 2 references for ABIN2009796

  4. Human FGFR1 Protein expressed in HEK-293 Cells - ABIN2181096 : Elbauomy Elsheikh, Green, Lambros, Turner, Grainge, Powe, Ellis, Reis-Filho: FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis. in Breast cancer research : BCR 2007 (PubMed)

More Proteins for FGFR1 Interaction Partners

Xenopus laevis Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. These results suggest that bFGF (show FGF2 Proteins) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.

  2. in FGFR1 signalling JNK1 (show MAPK8 Proteins) phosphorylation depends on ERK2 (show MAPK1 Proteins)

Fruit Fly (Drosophila melanogaster) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response

  2. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (show MSH2 Proteins), but does not require a differentiated visceral mesoderm.

  3. the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (show FGFR2 Proteins) inhibitor or if Heartless function is missing from the neurons.

Human Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. This research suggested that CTRP3 might protect chondrocytes against IL-1beta (show IL1B Proteins)-induced osteoarthritis in a cell model by suppressing the FGFR1- Ras/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling-mediated growth inhibitory pathway.

  2. FGFR1 amplification was identified in all types of lung carcinoma

  3. results demonstrated upregulation of FGFR1 and cytokeratin 20 (show KRT20 Proteins) expressions in cancer bladder tissues

  4. FGFR1 dimers forms a complex with its effector PLCgamma1 (show PLCG1 Proteins).

  5. Conformational equilibrium of 3 cancer mutants of FGFR1, located at the hinge region, the activation-loop and the gatekeeper residue at the ATP-binding pocket, respectively. NMR analyses showed that these 3 mutants induce the different conformational states, which were hybrid state between the inactive and the fully active states.

  6. A reduction in FGF-2 (show FGF2 Proteins) expression could contribute to age-related impaired function of human mesenchyme-derived progenitor cells via modulation of beta-catenin (show CTNNB1 Proteins) signaling via the FGFR1 receptor.

  7. High FGFR1 expression was associated with luminal A breast cancers.

  8. This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, squamous cell lung cancer (SQCC) and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.

  9. determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients

  10. FGFR1 contributes to cell proliferation in osteosarcoma MG63 cells, and FGFR1 mediated cell proliferation may be attributed to the regulation of the cell cycle regulator, CDK1 (show CDK1 Proteins).

Mouse (Murine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. Data suggest that Fgf1 (show FGF1 Proteins)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 Proteins)) and Fgfr1 (fibroblast growth factor receptor 1) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Proteins)).

  2. FGFR1OP2 (show FGFR1OP2 Proteins)-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A Proteins) and T-cell lymphoma in a mouse model.

  3. MiR (show MLXIP Proteins)-214 was up-regulated in mesenchymal stem cells of osteoporotic mice and down-regulated during osteoblast differentiation of mesenchymal stem cells. FGFR1 is a direct target of miR (show MLXIP Proteins)-214.

  4. demonstrated that Id1 (show ID1 Proteins) and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

  5. FGF receptor 1-mediated anosmin-1 (show KAL1 Proteins) activity plays a crucial role in the continuous remodelling of the adult olfactory bulb.

  6. Fgfr1 and Fgfr2 (show FGFR2 Proteins) in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation

  7. Data suggest that signal transduction via Fgf23 (show FGF23 Proteins)/Fgfr1 and calcitriol/calcitriol receptor have opposite roles in innate immunity; Fgf23 (show FGF23 Proteins) suppresses arginase-1 (show ARG1 Proteins) expression in macrophages; calcitriol stimulates arginase-1 (show ARG1 Proteins) expression in macrophages.

  8. FGFR1 has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 signaling in both phosphate and calcium homeostasis.

  9. Data demonstrate an essential role for FGFR1 and FGFR2 (show FGFR2 Proteins) in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response.

  10. Activation of FGFR1 is essential for the high levels of FGF23 (show FGF23 Proteins) in acute and chronic experimental uremia.

Cow (Bovine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Pig (Porcine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. mRNA and protein expression of FGFR-1, FGFR-2 (show FGFR2 Proteins) in the porcine umbilical cord during pregnancy.

Zebrafish Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.

  2. Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Proteins) fgfr1 are expressed in normal and regenerating barbel tissue.

  3. Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.

  4. fgfr (show FGFR2 Proteins) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.

  5. we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).

  6. knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration

  7. Bmp and Fgf signaling are essential for liver specification in zebrafish.

  8. The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 and fgfr4 (show FGFR4 Proteins), using combined spectroscopy methods are reported.

FGFR1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Alternative names and synonyms associated with FGFR1

  • fibroblast growth factor receptor (FGFR)
  • fibroblast growth factor receptor (fgfr)
  • fibroblast growth factor receptor 1 (fgfr1-a)
  • basic fibroblast growth factor receptor 1 (CpipJ_CPIJ005849)
  • heartless (htl)
  • fibroblast growth factor receptor 1 (fgfr1)
  • fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) (fgfr3)
  • fibroblast growth factor receptor 1 (FGFR1)
  • fibroblast growth factor receptor 1 (Fgfr1)
  • Fibroblast growth factor receptor 1 (Fgfr1)
  • fibroblast growth factor receptor 1 (fgfr1-b)
  • fibroblast growth factor receptor 1a (fgfr1a)
  • ach protein
  • AW208770 protein
  • bFGF-R-1 protein
  • BFGFR protein
  • cb231 protein
  • CD331 protein
  • cd333 protein
  • CEK protein
  • cek2 protein
  • CG7223 protein
  • CT22273 protein
  • CT39172 protein
  • DFGF-R1 protein
  • DFGF-R2 protein
  • Dfr-1 protein
  • Dfr1 protein
  • DFR1/DFGF-R2 protein
  • Dmel\\CG7223 protein
  • DmHD-38 protein
  • DPR3 protein
  • dtk1 protein
  • DTRK(FR1) protein
  • Eask protein
  • EMS2 protein
  • FGF-R2 protein
  • FGFBR protein
  • fgfr protein
  • Fgfr-1 protein
  • fgfr-3 protein
  • fgfr1 protein
  • FGFR2 protein
  • FGFRI protein
  • FLG protein
  • FLG-1 protein
  • Flt-2 protein
  • FLT2 protein
  • Fr1 protein
  • HBGFR protein
  • HD-38 protein
  • HH2 protein
  • hsfgfr3ex protein
  • Hspy protein
  • Htl protein
  • HTL/FGFR1 protein
  • i79 protein
  • i100 protein
  • i150 protein
  • j372 protein
  • jtk4 protein
  • KAL2 protein
  • N-SAM protein
  • OGD protein
  • sb:cb231 protein
  • Tk1 protein
  • x1fgfr protein
  • XFGFR-1 protein
  • xfgfr1 protein
  • XFGFRA2 protein

Protein level used designations for FGFR1

fibroblast growth factor receptor , FGFR-1 , fibroblast growth factor receptor-1 , basic fibroblast growth factor receptor 1 , CG7223-PA , CG7223-PB , CG7223-PC , FGF receptor , fibroblast growth factor receptor 1 , htl-PA , htl-PB , htl-PC , fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) , ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) , basic fibroblast growth factor receptor 1-like , FGFR1/PLAG1 fusion , FMS-like tyrosine kinase 2 , fms-related tyrosine kinase 2 , heparin-binding growth factor receptor , hydroxyaryl-protein kinase , proto-oncogene c-Fgr , MFR , bFGF-R-1 , c-fgr , FGF receptor-1 , bFGF-R , cek1 protein , tyrosine kinase receptor CEK1 , FGFR-1-A , bFGF-R-1-A , basic fibroblast growth factor receptor 1-A , fibroblast growth factor receptor 1-A

373310 Strongylocentrotus purpuratus
445706 Ciona intestinalis
394418 Xenopus laevis
6037802 Culex quinquefasciatus
42160 Drosophila melanogaster
548648 Xenopus (Silurana) tropicalis
779370 Xenopus laevis
100390192 Callithrix jacchus
2260 Homo sapiens
14182 Mus musculus
79114 Rattus norvegicus
475582 Canis lupus familiaris
281768 Bos taurus
464122 Pan troglodytes
100057614 Equus caballus
100153248 Sus scrofa
396516 Gallus gallus
100731156 Cavia porcellus
399444 Xenopus laevis
100351861 Oryctolagus cuniculus
30705 Danio rerio
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