Browse our FGFR1 Proteins (FGFR1)

Full name:
Fibroblast Growth Factor Receptor 1 Proteins (FGFR1)
On are 48 Fibroblast Growth Factor Receptor 1 (FGFR1) Proteins from 16 different suppliers available. Additionally we are shipping FGFR1 Antibodies (600) and FGFR1 Kits (40) and many more products for this protein. A total of 737 FGFR1 products are currently listed.
ach, AW208770, bFGF-R-1, BFGFR, cb231, CD331, cd333, CEK, cek2, CG7223, CT22273, CT39172, DFGF-R1, DFGF-R2, Dfr-1, Dfr1, DFR1/DFGF-R2, Dmel\\CG7223, DmHD-38, DPR3, dtk1, DTRK(FR1), Eask, EMS2, FGF-R2, FGFBR, fgfr, Fgfr-1, fgfr-3, fgfr1, FGFR2, FGFRI, FLG, FLG-1, Flt-2, FLT2, Fr1, HBGFR, HD-38, HH2, hsfgfr3ex, Hspy, Htl, HTL/FGFR1, i79, i100, i150, j372, jtk4, KAL2, N-SAM, OGD, sb:cb231, Tk1, x1fgfr, XFGFR-1, xfgfr1, XFGFRA2
list all proteins Gene Name GeneID UniProt
FGFR1 2260 P11362
FGFR1 14182 P16092
FGFR1 79114 Q04589

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FGFR1 Proteins (FGFR1) by Origin

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Top referenced FGFR1 Proteins

  1. Human FGFR1 Protein expressed in Human Cells - ABIN2003140 : Soker, Takashima, Miao, Neufeld, Klagsbrun: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. in Cell 1998 (PubMed)
    Show all 5 references for 2003140

  2. Mouse (Murine) FGFR1 Protein expressed in Human Cells - ABIN2007475 : Stauber, DiGabriele, Hendrickson: Structural interactions of fibroblast growth factor receptor with its ligands. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 4 references for 2007475

  3. Mouse (Murine) FGFR1 Protein expressed in Human Cells - ABIN2007477 : Yu, Zheng, Asa, Ezzat: Fibroblast growth factor receptor 4 (FGFR4) mediates signaling to the prolactin but not the FGFR4 promoter. in American journal of physiology. Endocrinology and metabolism 2002 (PubMed)
    Show all 4 references for 2007477

  4. Rhesus Monkey FGFR1 Protein expressed in Human Cells - ABIN2009798 : Hunter, Kraft, Jacobs, Cox, Yeager, Hankinson, Wacholder, Wang, Welch, Hutchinson, Wang, Yu, Chatterjee, Orr, Willett, Colditz, Ziegler, Berg, Buys, McCarty, Feigelson, Calle, Thun, Hayes, Tucker et al.: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. ... in Nature genetics 2007 (PubMed)
    Show all 2 references for 2009798

  5. Human FGFR1 Protein expressed in HEK-293 Cells - ABIN2181096 : Elbauomy Elsheikh, Green, Lambros, Turner, Grainge, Powe, Ellis, Reis-Filho: FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis. in Breast cancer research : BCR 2007 (PubMed)

More Proteins for FGFR1 Interaction Partners

Xenopus laevis Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. These results suggest that bFGF (show FGF2 Proteins) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.

  2. in FGFR1 signalling JNK1 (show MAPK8 Proteins) phosphorylation depends on ERK2 (show MAPK1 Proteins)

Fruit Fly (Drosophila melanogaster) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response

  2. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (show MSH2 Proteins), but does not require a differentiated visceral mesoderm.

  3. the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (show FGFR2 Proteins) inhibitor or if Heartless function is missing from the neurons.

Human Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. Liposarcoma patients harboring FGFR1/3 mutations experienced reduced overall survival.

  2. We observed that SNPs rs13317 and rs6996321 were correlated with the overall head size and midfacial development, indicating that FGFR1 SNPs played crucial roles in the normal variation of human craniofacial morphology.

  3. NCAM (show NCAM1 Proteins)- and FGF-2 (show FGF2 Proteins)-mediated FGFR1 signaling in the tumor microenvironment regulates the survival and migration of esophageal squamous carcinoma cells.

  4. in one holoprosencephaly (HPE) family, a deleterious FGFR1 allele was transmitted from one parent and a loss-of-function allele in FGF8 from the other parent to both affected daughters. This family is one of the clearest examples to date of gene:gene synergistic interactions causing HPE in humans.

  5. High FGFR1 expression is associated with Radioresistance in Glioblastoma.

  6. Genetic, bioinformatics, biochemical and biophysical data show that attraction between this alpha1-conjugated ubiquitin and the HECT ubiquitin-binding patch pulls the alpha1-helix out of the interface, thereby promoting trimerization. Strikingly, trimerization renders the ubiquitin ligase inactive.

  7. Data indicate consistent results between molecular inversion probe (MIP (show TNPO1 Proteins)) microarray and next-generation sequencing (NGS) in detecting HER2 (show ERBB2 Proteins) protein and fibroblast growth factor receptor 1 (FGFR1) amplification in breast cancer.

  8. we identified heterozygous loss-of-function mutations of FGFR1 in four patients with HH-SHFM. Of note, this study indicates that loss of the promoter region around exon 1U underlies FGFR1-related disorders.

  9. A novel dominant negative FGFR1 mutation identified in the Kallman syndrome patient.

  10. High FGFR1 expression was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease in gastric cancer.

Mouse (Murine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. MAPK (show MAPK1 Proteins) cascades participate in osteogenesis, but only the ERK (show EPHB2 Proteins) signaling pathway responds to FGFR1.

  2. It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 Proteins) 2, in the oligodendr

  3. data suggest that FGF2 (show FGF2 Proteins) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (show FGFR2 Proteins), and FGFR3 (show FGFR3 Proteins).

  4. clearly demonstrate the different specificity of FGF12 (show FGF12 Proteins)-FGFR1c2 and FGF22 (show FGF22 Proteins)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling

  5. The study supports a pro-adipogenic role for betaKlotho (show KLB Proteins) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (show FGFR2 Proteins)-betaKlotho (show KLB Proteins) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.

  6. These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.

  7. Data suggest that Fgf1 (show FGF1 Proteins)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 Proteins)) and Fgfr1 (fibroblast growth factor receptor 1) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Proteins)).

  8. FGFR1OP2 (show FGFR1OP2 Proteins)-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A Proteins) and T-cell lymphoma in a mouse model.

  9. MiR (show MLXIP Proteins)-214 was up-regulated in mesenchymal stem cells of osteoporotic mice and down-regulated during osteoblast differentiation of mesenchymal stem cells. FGFR1 is a direct target of miR (show MLXIP Proteins)-214.

  10. demonstrated that Id1 (show ID1 Proteins) and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

Cow (Bovine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Pig (Porcine) Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. mRNA and protein expression of FGFR-1, FGFR-2 (show FGFR2 Proteins) in the porcine umbilical cord during pregnancy.

Zebrafish Fibroblast Growth Factor Receptor 1 (FGFR1) interaction partners

  1. Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays

  2. we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.

  3. Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Proteins) fgfr1 are expressed in normal and regenerating barbel tissue.

  4. Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.

  5. fgfr (show FGFR2 Proteins) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.

  6. we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).

  7. knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration

  8. Bmp and Fgf signaling are essential for liver specification in zebrafish.

  9. The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 and fgfr4 (show FGFR4 Proteins), using combined spectroscopy methods are reported.

FGFR1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Alternative names and synonyms associated with FGFR1

  • fibroblast growth factor receptor (FGFR)
  • fibroblast growth factor receptor (fgfr)
  • fibroblast growth factor receptor 1 (fgfr1-a)
  • basic fibroblast growth factor receptor 1 (CpipJ_CPIJ005849)
  • heartless (htl)
  • fibroblast growth factor receptor 1 (fgfr1)
  • fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) (fgfr3)
  • fibroblast growth factor receptor 1 (FGFR1)
  • fibroblast growth factor receptor 1 (Fgfr1)
  • Fibroblast growth factor receptor 1 (Fgfr1)
  • fibroblast growth factor receptor 1 (fgfr1-b)
  • fibroblast growth factor receptor 1a (fgfr1a)
  • ach protein
  • AW208770 protein
  • bFGF-R-1 protein
  • BFGFR protein
  • cb231 protein
  • CD331 protein
  • cd333 protein
  • CEK protein
  • cek2 protein
  • CG7223 protein
  • CT22273 protein
  • CT39172 protein
  • DFGF-R1 protein
  • DFGF-R2 protein
  • Dfr-1 protein
  • Dfr1 protein
  • DFR1/DFGF-R2 protein
  • Dmel\\CG7223 protein
  • DmHD-38 protein
  • DPR3 protein
  • dtk1 protein
  • DTRK(FR1) protein
  • Eask protein
  • EMS2 protein
  • FGF-R2 protein
  • FGFBR protein
  • fgfr protein
  • Fgfr-1 protein
  • fgfr-3 protein
  • fgfr1 protein
  • FGFR2 protein
  • FGFRI protein
  • FLG protein
  • FLG-1 protein
  • Flt-2 protein
  • FLT2 protein
  • Fr1 protein
  • HBGFR protein
  • HD-38 protein
  • HH2 protein
  • hsfgfr3ex protein
  • Hspy protein
  • Htl protein
  • HTL/FGFR1 protein
  • i79 protein
  • i100 protein
  • i150 protein
  • j372 protein
  • jtk4 protein
  • KAL2 protein
  • N-SAM protein
  • OGD protein
  • sb:cb231 protein
  • Tk1 protein
  • x1fgfr protein
  • XFGFR-1 protein
  • xfgfr1 protein
  • XFGFRA2 protein

Protein level used designations for FGFR1

fibroblast growth factor receptor , FGFR-1 , fibroblast growth factor receptor-1 , basic fibroblast growth factor receptor 1 , CG7223-PA , CG7223-PB , CG7223-PC , FGF receptor , fibroblast growth factor receptor 1 , htl-PA , htl-PB , htl-PC , fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) , ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) , basic fibroblast growth factor receptor 1-like , FGFR1/PLAG1 fusion , FMS-like tyrosine kinase 2 , fms-related tyrosine kinase 2 , heparin-binding growth factor receptor , hydroxyaryl-protein kinase , proto-oncogene c-Fgr , MFR , bFGF-R-1 , c-fgr , FGF receptor-1 , bFGF-R , cek1 protein , tyrosine kinase receptor CEK1 , FGFR-1-A , bFGF-R-1-A , basic fibroblast growth factor receptor 1-A , fibroblast growth factor receptor 1-A

373310 Strongylocentrotus purpuratus
445706 Ciona intestinalis
394418 Xenopus laevis
6037802 Culex quinquefasciatus
42160 Drosophila melanogaster
548648 Xenopus (Silurana) tropicalis
779370 Xenopus laevis
100390192 Callithrix jacchus
2260 Homo sapiens
14182 Mus musculus
79114 Rattus norvegicus
475582 Canis lupus familiaris
281768 Bos taurus
464122 Pan troglodytes
100057614 Equus caballus
100153248 Sus scrofa
396516 Gallus gallus
100731156 Cavia porcellus
399444 Xenopus laevis
100351861 Oryctolagus cuniculus
30705 Danio rerio
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