FGFR1 Protein (AA 22-374) (His-Avi Tag)
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- Target See all FGFR1 Proteins
- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-374
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGFR1 protein is labelled with His-Avi Tag.
- Purpose
- Human FGFR1 alpha (IIIc) Protein
- Sequence
- Arg22-Glu374
- Characteristics
- Recombinant Human FGFR1 alpha (IIIc) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Arg22-Glu374.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human FGFR1 alpha (IIIc) at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-FGFR1 Antibody, hFc Tag with the EC50 of 12.9ng/ml determined by ELISA. See testing image for detail.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
- Alternative Name
- FGFR1 alpha (FGFR1 Products)
- Synonyms
- FGFR Protein, fgfr Protein, X1FGFR Protein, XFGFR-1 Protein, XFGFRA2 Protein, bfgfr Protein, cek Protein, fgfr1 Protein, flg Protein, flt-2 Protein, flt2 Protein, kal2 Protein, ogd Protein, xfgfr1 Protein, CG7223 Protein, CT22273 Protein, CT39172 Protein, DFGF-R1 Protein, DFGF-R2 Protein, DFR-1 Protein, DFR1 Protein, DFR1/DFGF-R2 Protein, DPR3 Protein, DTRK(FR1) Protein, Dfr-1 Protein, Dfr1 Protein, DmHD-38 Protein, Dmel\\CG7223 Protein, Dtk1 Protein, EMS2 Protein, FGF-R2 Protein, FGFR2 Protein, FR1 Protein, Fr1 Protein, HD-38 Protein, HTL/FGFR1 Protein, Htl Protein, Tk1 Protein, dtk1 Protein, i100 Protein, i150 Protein, i79 Protein, j372 Protein, cd331 Protein, fgfbr Protein, fgfr-1 Protein, hbgfr Protein, n-sam Protein, ach Protein, cd333 Protein, cek2 Protein, fgfr-3 Protein, hsfgfr3ex Protein, jtk4 Protein, BFGFR Protein, CD331 Protein, CEK Protein, FGFBR Protein, FGFR-1 Protein, FLG Protein, FLT-2 Protein, FLT2 Protein, HBGFR Protein, HH2 Protein, KAL2 Protein, N-SAM Protein, OGD Protein, bFGF-R-1 Protein, AW208770 Protein, Eask Protein, Fgfr-1 Protein, Flt-2 Protein, Hspy Protein, FLG-1 Protein, FGFRI Protein, x1fgfr Protein, cb231 Protein, sb:cb231 Protein, fibroblast growth factor receptor Protein, fibroblast growth factor receptor 1 S homeolog Protein, basic fibroblast growth factor receptor 1 Protein, heartless Protein, fibroblast growth factor receptor 1 Protein, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog Protein, Fibroblast growth factor receptor 1 Protein, fibroblast growth factor receptor 1 L homeolog Protein, fibroblast growth factor receptor 1a Protein, FGFR Protein, fgfr Protein, fgfr1.S Protein, CpipJ_CPIJ005849 Protein, htl Protein, fgfr1 Protein, fgfr3.L Protein, FGFR1 Protein, Fgfr1 Protein, fgfr1.L Protein, fgfr1a Protein
- Background
- Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
- Molecular Weight
- 42 kDa. Due to glycosylation, the protein migrates to 68-83 kDa based on Tris-Bis PAGE result.
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
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