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Browse our FGFR2 Proteins (FGFR2)

Full name:
Fibroblast Growth Factor Receptor 2 Proteins (FGFR2)
On are 44 Fibroblast Growth Factor Receptor 2 (FGFR2) Proteins from 13 different suppliers available. Additionally we are shipping FGFR2 Antibodies (300) and FGFR2 Kits (22) and many more products for this protein. A total of 395 FGFR2 products are currently listed.
AU043015, AW556123, BBDS, Bek, BFR-1, CD332, CEK3, CFD1, DKFZp469H1521, ECT1, fc56c05, FGF-R, FGFR, Fgfr-2, Fgfr-7, FGFR2, FGFR2IIIb, Fgfr7, fgfr72IIIb, JWS, K-SAM, KGFR, KGFRTr, svs, TK14, TK25, wu:fc56c05, xfgfr2
list all proteins Gene Name GeneID UniProt
FGFR2 2263 P21802
FGFR2 14183 P21803
Rat FGFR2 FGFR2 25022  

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FGFR2 Proteins (FGFR2) by Origin

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Top referenced FGFR2 Proteins

  1. Human FGFR2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003454 : Stauber, DiGabriele, Hendrickson: Structural interactions of fibroblast growth factor receptor with its ligands. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 3 references for ABIN2003454

  2. Mouse (Murine) FGFR2 Protein expressed in Human Cells - ABIN2008660 : Yu, Zheng, Asa, Ezzat: Fibroblast growth factor receptor 4 (FGFR4) mediates signaling to the prolactin but not the FGFR4 promoter. in American journal of physiology. Endocrinology and metabolism 2002 (PubMed)
    Show all 3 references for ABIN2008660

  3. Human FGFR2 Protein expressed in Human Cells - ABIN2003451 : Hunter, Kraft, Jacobs, Cox, Yeager, Hankinson, Wacholder, Wang, Welch, Hutchinson, Wang, Yu, Chatterjee, Orr, Willett, Colditz, Ziegler, Berg, Buys, McCarty, Feigelson, Calle, Thun, Hayes, Tucker et al.: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. ... in Nature genetics 2007 (PubMed)
    Show all 3 references for ABIN2003451

More Proteins for FGFR2 Interaction Partners

Human Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

  1. Two novel FGFR 2 gene missense mutations in Chinese patients with Crouzon syndrome were identified.

  2. Incidence of progression (progressed, recurred or died from disease) of endometrioid endometrial cancer was significantly more prevalent (32/125, 26%) among patients with FGFR2 mutation versus wild type (120/848, 14%; p<0.001, Chi-square test).

  3. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 Proteins). As well as defining a novel mechanism of Akt (show AKT1 Proteins) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2, Plc11 and Grb2 (show GRB2 Proteins) correlate with patient survival

  4. High FGFR2 expression was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease in gastric cancer.

  5. fibroblast growth factor receptor 2 overexpression is correlated with decreased survival in most solid tumors, suggesting that the expression status of fibroblast growth factor receptor 2 is a valuable prognostic biomarker and a novel therapeutic target in human solid tumors.

  6. The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2.

  7. We thus propose a molecular mechanism by which FGFR2 can confer increased breast cancer risk that is consistent with oestrogen exposure as a major driver of breast cancer risk. Our findings may have implications for the clinical use of FGFR2 inhibitors.

  8. There was an increased effect of Breast Cancer risk between haplotype combinations of the two Single nucleotide polymorphisms of FGFR2 (rs2981582 and rs1219648) in Pakistani women.

  9. Our meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of BC. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.

  10. FGFR2 expression by IHC might be a useful biomarker for predicting treatment outcomes of patients with metastatic or recurrent AGC (show ACAN Proteins) treated with a combination of pazopanib and CapeOx

Mouse (Murine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

  1. Ectopic expression of Fgfr2c was detected within the affected sutures of Bcl11b(-/-) mice. Ectopic expression of Fgfr2c in the sutural mesenchyme, without concomitant changes in the expression of FGF ligands, appears to induce the RUNX2-dependent osteogenic program and craniosynostosis in Bcl11b(-/-) mice.

  2. Calvarial osteoblasts from Fgfr2c gain-of-function mice had enhanced osteoblastic function and maturation with concomitant increase in ERK-MAPK (show MAPK1 Proteins) activation. In vitro inhibition with U0126 mitigated ERK (show EPHB2 Proteins) protein activation levels and reduced alkaline phosphatase activity. FGFR2c-mediated ERK-MAPK (show MAPK1 Proteins) signaling is a key mediator of craniofacial growth and coronal suture development.

  3. Fgfr1 (show FGFR1 Proteins) and Fgfr2 in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation

  4. Data demonstrate an essential role for FGFR1 (show FGFR1 Proteins) and FGFR2 in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response.

  5. isolated deletion of Pten failed to stimulate ectopic fiber cell differentiation, and the combined deletion of Pten and Fgfr2 failed to restore differentiation-specific Aquaporin0 and DnaseIIbeta expression in the lens fiber cells

  6. The results of this study concluded that since the OPC response was not altered in Fgfr1 (show FGFR1 Proteins)/Fgfr2 dKO mice either after initial demyelination or after chronic demyelination.

  7. work suggests that FGFR2IIIb and IIIc isoforms largely act redundantly to promote expansion of the adrenocortical primordium.

  8. miR (show MLXIP Proteins)-223 regulates adipocyte and osteoblast differentiation through a novel C/EBPs/miR (show MLXIP Proteins)-223/FGFR2 regulatory feedback loop.

  9. Conditional knockout of Fgfr2 revealed stage- and tissue-specficic roles of FGF signaling in multiple processes of external genitalia development among the 3 tissue layers at each developmental stage.

  10. Study demonstrates that FGFR2 plays an essential role in controlling cell proliferation and differentiation, and maintaining Pax6 (show PAX6 Proteins) levels in corneal epithelium via ERK (show EPHB2 Proteins)-independent pathways during embryonic development.

Pig (Porcine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

  1. mRNA and protein expression of FGFR-1 (show FGFR1 Proteins), FGFR-2 in the porcine umbilical cord during pregnancy.

  2. EGFR (show EGFR Proteins), VEGFR (show KDR Proteins) and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]

  3. analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7 (show FGF7 Proteins)) and its receptor FGFR2IIIb

Cow (Bovine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

  1. FGF10 (show FGF10 Proteins) and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 (show FGF10 Proteins) acts as an important regulator of follicular growth in cattle.

  2. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  3. These data support a role for FGF10 (show FGF10 Proteins) and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)

  4. FGF10 (show FGF10 Proteins) mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha

Zebrafish Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

  1. we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.

  2. the roles of Fgfr2 signaling in zebrafish left-right asymmetry

FGFR2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with FGFR2

  • fibroblast growth factor receptor 2 (FGFR2)
  • fibroblast growth factor receptor 2 (fgfr2)
  • fibroblast growth factor receptor 2 (Fgfr2)
  • AU043015 protein
  • AW556123 protein
  • BBDS protein
  • Bek protein
  • BFR-1 protein
  • CD332 protein
  • CEK3 protein
  • CFD1 protein
  • DKFZp469H1521 protein
  • ECT1 protein
  • fc56c05 protein
  • FGF-R protein
  • FGFR protein
  • Fgfr-2 protein
  • Fgfr-7 protein
  • FGFR2 protein
  • FGFR2IIIb protein
  • Fgfr7 protein
  • fgfr72IIIb protein
  • JWS protein
  • K-SAM protein
  • KGFR protein
  • KGFRTr protein
  • svs protein
  • TK14 protein
  • TK25 protein
  • wu:fc56c05 protein
  • xfgfr2 protein

Protein level used designations for FGFR2

fibroblast growth factor receptor 2 , bacteria-expressed kinase , keratinocyte growth factor receptor , fibroblast growth factor receptor 2 IIIb , fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) , BEK fibroblast growth factor receptor , FGF receptor , FGFR-2 , hydroxyaryl-protein kinase , protein tyrosine kinase, receptor like 14 , soluble FGFR4 variant 4 , FGF-7 receptor 2IIIb , fgf receptor , chicken tyrosine kinase (cek3) , receptor tyrosine kinase , tyrosine kinase receptor CEK3 , fibroblast growth factor receptor-2

443548 Ovis aries
466220 Pan troglodytes
715949 Macaca mulatta
100033956 Equus caballus
100084641 Ornithorhynchus anatinus
100124910 Xenopus (Silurana) tropicalis
100171540 Pongo abelii
100468267 Ailuropoda melanoleuca
2263 Homo sapiens
14183 Mus musculus
25022 Rattus norvegicus
415125 Canis lupus familiaris
396762 Sus scrofa
404193 Bos taurus
396259 Gallus gallus
399325 Xenopus laevis
100009417 Oryctolagus cuniculus
100379152 Cavia porcellus
352940 Danio rerio
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