FGFR2 Products
(Fibroblast Growth Factor Receptor 2 (FGFR2))
Categories
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
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Featured FGFR2 Categories
FGFR2 Antibodies
High quality antibodies with extensive validation data.
FGFR2 ELISA Kits
Reliable ELISA kits for a wide range of species.
FGFR2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FGFR2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (5)
- (7)
Cat. No.
ABIN391965
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC
Validations
- (7)
Cat. No.
ABIN3022855
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN391968
Quantity
400 μL
Datasheet
Datasheet
Recommended FGFR2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955878
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381135
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886102
Quantity
96 tests
Datasheet
Datasheet
Recommended FGFR2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570009
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570166
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354041
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our FGFR2 products
: "Leucocyte and Platelet-rich Fibrin: a carrier of autologous multipotent cells for regenerative medicine." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1840-1854, (2018) (PubMed).: "Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia." in: Oncotarget, Vol. 8, Issue 50, pp. 87095-87106, (2017) (PubMed).
: "Interactions between FGFR2 and RSK2-implications for breast cancer prognosis." in: Tumour biology, Vol. 37, Issue 10, pp. 13721-13731, (2016) (PubMed).
: "miR-223 Regulates Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells Through a C/EBPs/miR-223/FGFR2 Regulatory Feedback Loop." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 5, pp. 1589-600, (2015) (PubMed).
: "Upregulation of ANGPTL4 messenger RNA and protein in severely calcified carotid plaques." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 23, Issue 5, pp. 933-47, (2014) (PubMed).
: "Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets." in: Annals of surgical oncology, Vol. 21, Issue 5, pp. 1561-8, (2014) (PubMed).
: "Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity." in: PLoS ONE, Vol. 9, Issue 10, pp. e110345, (2014) (PubMed).
: "Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells." in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, (2014) (PubMed).
: "Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC." in: Cancer research, Vol. 74, Issue 17, pp. 4676-84, (2014) (PubMed).
: "The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro." in: Reproduction (Cambridge, England), Vol. 145, Issue 2, pp. 191-201, (2013) (PubMed).
Synonyms and alternative names related to FGFR2
fibroblast growth factor receptor 2 (FGFR2), fibroblast growth factor receptor 2 (LOC100084641), fibroblast growth factor receptor 2 (fgfr2), fibroblast growth factor receptor 2 (Fgfr2), fibroblast growth factor receptor 2 L homeolog (fgfr2.L), AU043015, AW556123, BBDS, bek, BEK, Bek, bfr-1, BFR-1, cd332, CD332, cek3, CEK3, cfd1, CFD1, DKFZp469H1521, ect1, ECT1, fc56c05, FGF-R, FGFR, fgfr-2, Fgfr-2, Fgfr-7, FGFR2, FGFR2IIIb, Fgfr7, fgfr72IIIb, jws, JWS, k-sam, K-SAM, kgfr, KGFR, KGFRTr, svs, tk14, TK14, tk25, TK25, wu:fc56c05, xfgfr2Protein level used designations for FGFR2
- fibroblast growth factor receptor 2
- bacteria-expressed kinase
- keratinocyte growth factor receptor
- fibroblast growth factor receptor 2 IIIb
- fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
- BEK fibroblast growth factor receptor
- FGF receptor
- FGFR-2
- hydroxyaryl-protein kinase
- protein tyrosine kinase, receptor like 14
- soluble FGFR4 variant 4
- FGF-7 receptor 2IIIb
- fgf receptor
- chicken tyrosine kinase (cek3)
- receptor tyrosine kinase
- tyrosine kinase receptor CEK3
- fibroblast growth factor receptor-2
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