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Human FGFR3 ELISA Kit for Sandwich ELISA - ABIN417740
Siegel, Kluba, Hermanutz-Klein, Bieback, Northoff, Schäfer: Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells. in BMC medicine 2013
Show all 2 references for ABIN417740
General FGFR3 ELISA Kit for Competition ELISA - ABIN1118060
Xiao, Li, Zhang, Hou, Lin, Gao, Luo: Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain. in Neuroscience bulletin 2011
analysis of FGFR3 and FGFR4 (show FGFR4 ELISA Kits) gene polymorphisms in breast cancer in Chinese women of Heilongjiang province reveals that SNPs rs1966265 and rs351855 in FGFR4 (show FGFR4 ELISA Kits) , but not rs2234909 and rs3135848 in FGFR3 are associated with breast cancer
The FGFR3, PIK3CA (show PIK3CA ELISA Kits), TERT (show TERT ELISA Kits) mutations, along with aberrant DNA methylation (show HELLS ELISA Kits) patterns, can serve as reliable genetic markers for the diagnosis of urinary bladder cancer. (Review)
The most notable effect of the achondroplasia mutation is increased propensity for FGFR3 dimerization in the absence of ligand.
Findings provide new evidence that PRMT5 (show PRMT5 ELISA Kits) plays an important role in CRC (show CALR ELISA Kits) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E (show EIF4E ELISA Kits) and FGFR3.
Expression of FGF-2 (show FGF2 ELISA Kits), FGFR-2 (show FGFR2 ELISA Kits) and FGFR-3 was upregulated in patients with potentially malignant oral lesions serving as biomarkers of malignant transformation to oral squamous cell carcinoma.
FGF receptor (FGFR) 3 may serve as a promising biomarker for Bladder Cancer. Mutations of this gene are prevalent in BC.
miR (show MLXIP ELISA Kits)-100 may activate MMP13 (show MMP13 ELISA Kits) through 3'UTR (show UTS2R ELISA Kits)-suppressoin of FGFR3 mRNA to facilitate development of lumbar disc degeneration.
Among patients with an FGFR3 mutation in the initial tumor, a noninvasive urine test during follow-up can be valuable in diagnosing or predicting subsequent recurrence.
TP53 (show TP53 ELISA Kits) and FGFR3 mutations in bladder tumors increased and decreased respectively with increasing tumor stage and cellular grade.
our data demonstrate that miR (show MLXIP ELISA Kits)-100 may inhibit the growth of Osteosarcoma through FGFR3.
loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK (show MDK ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling and upregulation of IHH (show IHH ELISA Kits).
A proliferation-independent and SOX9 (show SOX9 ELISA Kits)-dependent differentiation block is a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders caused by mutations in FGFR3.
This study showed constitutively active form of Fgfr3 to increase FGF signaling.
FGFR3 induces degradation of Bmpr1a to regulate skeletal development.
microtubule formation is a major downstream effector of Fgf-receptor 3 and this pathway impacts the formation of fluid spaces in the organ of Corti.
FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.
FGFR3 overexpression in lung leads to adenocarcinoma.
our results demonstrate that FGFR1 (show FGFR1 ELISA Kits) is crucial for S115 breast cancer cell proliferation and tumor growth and angiogenesis, whereas FGFR2 (show FGFR2 ELISA Kits) and FGFR3 are less critical for the growth of these cells
Peptide P3 inhibited tyrosine kinase (show TYRO3 ELISA Kits) activity of FGFR3 and the ERK/MAPK (show MAPK1 ELISA Kits) pathway.
dysregulation of Sox9 (show SOX9 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) levels and activity in growth plate chondrocytes is an important underlying mechanism in skeletal diseases caused by mutations in FGFR3
The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.
Alterations in the expression of VEGF-A (show VEGFA ELISA Kits) and bFGF (show FGF2 ELISA Kits) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
fibroblast growth factor receptor 3
, fibroblast growth factor receptor 3 variant 4
, hydroxyaryl-protein kinase
, tyrosine kinase JTK4
, heparin-binding growth factor receptor
, fibroblast growth factor receptor 3-IIIc
, tyrosine kinase (cek2)
, tyrosine kinase receptor CEK2
, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)