Browse our anti-FLT3 (FLT3) Antibodies

Full name:
anti-Fms-Related tyrosine Kinase 3 Antibodies (FLT3)
On www.antibodies-online.com are 355 Fms-Related tyrosine Kinase 3 (FLT3) Antibodies from 34 different suppliers available. Additionally we are shipping FLT3 Kits (39) and FLT3 Proteins (26) and many more products for this protein. A total of 431 FLT3 products are currently listed.
Synonyms:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all antibodies Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
FLT3 140635  

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Most Popular Reactivities for anti-FLT3 (FLT3) Antibodies

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anti-Mouse (Murine) FLT3 Antibodies:

anti-Human FLT3 Antibodies:

anti-Rat (Rattus) FLT3 Antibodies:

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Top referenced anti-FLT3 Antibodies

  1. Human Polyclonal FLT3 Primary Antibody for EIA, IHC (p) - ABIN359869 : Seidlits, Reza, Briand, Sereno: Voluntary spatial attention has different effects on voluntary and reflexive saccades. in TheScientificWorldJournal 2003 (PubMed)
    Show all 5 references for 359869

  2. Human Polyclonal FLT3 Primary Antibody for EIA, IHC (p) - ABIN359868 : Minami, Yamamoto, Kiyoi, Ueda, Saito, Naoe: Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. in Blood 2003 (PubMed)
    Show all 5 references for 359868

  3. Human Polyclonal FLT3 Primary Antibody for IHC (p), WB - ABIN391982 : Zwaan, Meshinchi, Radich, Veerman, Huismans, Munske, Podleschny, Hählen, Pieters, Zimmermann, Reinhardt, Harbott, Creutzig, Kaspers, Griesinger: FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. in Blood 2003 (PubMed)
    Show all 4 references for 391982

  4. Human Polyclonal FLT3 Primary Antibody for FACS, IHC (p) - ABIN391981 : Sitnicka, Buza-Vidas, Larsson, Nygren, Liuba, Jacobsen et al.: Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic ... in Blood 2003 (PubMed)
    Show all 4 references for 391981

  5. Human Polyclonal FLT3 Primary Antibody for IF, WB - ABIN401556 : Sekine, Kataoka, Fukuyama, Adachi, Davydova, Yamamoto, Kobayashi, Fujihashi, Suzuki, Curiel, Shizukuishi, McGhee, Fujihashi: A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 3 references for 401556

  6. Human Polyclonal FLT3 Primary Antibody for EIA, IF - ABIN1449983 : Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. in Journal of hematology & oncology 2011 (PubMed)
    Show all 3 references for 1449983

  7. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1532338 : Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. in Blood 1993 (PubMed)
    Show all 2 references for 1532338

  8. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1532044 : Rosnet, Matteï, Marchetto, Birnbaum: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. in Genomics 1991 (PubMed)
    Show all 2 references for 1532044

  9. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1531319 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
    Show all 2 references for 1531319

More Antibodies against FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. the Hoxa9 (show HOXA9 Antibodies)- and Meis1 (show MEIS1 Antibodies)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (show RUNX1 Antibodies) pathology.

  2. lineage-specific STAT5 (show STAT5A Antibodies) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  3. DOCK2 (show DOCK2 Antibodies) is a potential therapeutic target for novel AML (show RUNX1 Antibodies) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Used a genetic model to determine whether miR (show MLXIP Antibodies)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (show MLXIP Antibodies)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (show MLXIP Antibodies)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (show IFNA Antibodies) response.

  5. Overexpression of Abl (show ABL1 Antibodies)-related gene tyrosine kinase (show TYRO3 Antibodies) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  6. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  7. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21 (show D4S234E Antibodies)/Pbx1 (show PBX1 Antibodies) axis

  8. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (show TYRO3 Antibodies) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  9. DNMT3A (show DNMT3A Antibodies) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Antibodies).

  10. murine Fms-like tyrosine kinase 3 (Flt3) ligand (show FLT3LG Antibodies) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (show SLC11A1 Antibodies)) infection in vitro.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Y842 is critical for FLT3-mediated RAS/ERK (show EPHB2 Antibodies) signaling and cellular transformation.

  2. value of FLT3-ITD allelic ratio in AML (show RUNX1 Antibodies) in risk assessment and evaluating prognosis

  3. DOCK2 (show DOCK2 Antibodies) is a potential therapeutic target for novel AML (show RUNX1 Antibodies) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (show PIK3CA Antibodies)/mTOR (show FRAP1 Antibodies) pathway in FLT3-ITD-dependent AML (show RUNX1 Antibodies) results in resistance to drugs targeting FLT3.

  5. HHEX (show HHEX Antibodies) could replace RUNX1 (show RUNX1 Antibodies) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)).

  6. mutated FLT3-ITD and JAK2 (show JAK2 Antibodies) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  7. these data reveal a novel mechanism which regulates acute myeloid leukemia (show BCL11A Antibodies) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  8. MSI2 (show MSI2 Antibodies) and FLT3 are significantly co-regulated in human AML (show RUNX1 Antibodies)

  9. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  10. Factors that did not influence the relapse risk included: age, graft type, graft source, type of FLT3 mutation, or conditioning intensity

FLT3 Antigen Profile

Antigen Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) antibody
  • FMS-like tyrosine kinase 3 (Flt3) antibody
  • fms-related tyrosine kinase 3 (Flt3) antibody
  • B230315G04 antibody
  • CD135 antibody
  • FLK-2 antibody
  • FLK2 antibody
  • Flt-3 antibody
  • FLT3 antibody
  • Ly72 antibody
  • STK1 antibody
  • wmfl antibody

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPECIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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