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Browse our anti-FLT3 (FLT3) Antibodies

Full name:
anti-Fms-Related tyrosine Kinase 3 Antibodies (FLT3)
On www.antibodies-online.com are 351 Fms-Related tyrosine Kinase 3 (FLT3) Antibodies from 34 different suppliers available. Additionally we are shipping FLT3 Kits (39) and FLT3 Proteins (26) and many more products for this protein. A total of 427 FLT3 products are currently listed.
Synonyms:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all antibodies Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
FLT3 140635  

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Most Popular Reactivities for anti-FLT3 (FLT3) Antibodies

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anti-Mouse (Murine) FLT3 Antibodies:

anti-Human FLT3 Antibodies:

anti-Rat (Rattus) FLT3 Antibodies:

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Top referenced anti-FLT3 Antibodies

  1. Human Polyclonal FLT3 Primary Antibody for EIA, IHC (p) - ABIN359868 : Minami, Yamamoto, Kiyoi, Ueda, Saito, Naoe: Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. in Blood 2003 (PubMed)
    Show all 5 references for ABIN359868

  2. Human Polyclonal FLT3 Primary Antibody for EIA, IHC (p) - ABIN359869 : Seidlits, Reza, Briand, Sereno: Voluntary spatial attention has different effects on voluntary and reflexive saccades. in TheScientificWorldJournal 2003 (PubMed)
    Show all 5 references for ABIN359869

  3. Human Polyclonal FLT3 Primary Antibody for FACS, IHC (p) - ABIN391981 : Zwaan, Meshinchi, Radich, Veerman, Huismans, Munske, Podleschny, Hählen, Pieters, Zimmermann, Reinhardt, Harbott, Creutzig, Kaspers, Griesinger: FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. in Blood 2003 (PubMed)
    Show all 4 references for ABIN391981

  4. Human Polyclonal FLT3 Primary Antibody for IHC (p), WB - ABIN391982 : Sitnicka, Buza-Vidas, Larsson, Nygren, Liuba, Jacobsen et al.: Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic ... in Blood 2003 (PubMed)
    Show all 4 references for ABIN391982

  5. Human Polyclonal FLT3 Primary Antibody for IF, WB - ABIN401556 : Sekine, Kataoka, Fukuyama, Adachi, Davydova, Yamamoto, Kobayashi, Fujihashi, Suzuki, Curiel, Shizukuishi, McGhee, Fujihashi: A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 3 references for ABIN401556

  6. Human Polyclonal FLT3 Primary Antibody for EIA, IF - ABIN1449983 : Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. in Journal of hematology & oncology 2011 (PubMed)
    Show all 3 references for ABIN1449983

  7. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1532338 : Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. in Blood 1993 (PubMed)
    Show all 2 references for ABIN1532338

  8. Human Polyclonal FLT3 Primary Antibody for IHC, ELISA - ABIN1532045 : Rosnet, Matteï, Marchetto, Birnbaum: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. in Genomics 1991 (PubMed)
    Show all 2 references for ABIN1532045

  9. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1531319 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
    Show all 2 references for ABIN1531319

More Antibodies against FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. DNMT3A (show DNMT3A Antibodies) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Antibodies).

  2. murine Fms-like tyrosine kinase 3 (Flt3) ligand (show FLT3LG Antibodies) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (show SLC11A1 Antibodies)) infection in vitro.

  3. increased number of osteoclasts in Flt3L (show FLT3LG Antibodies)(-/-) mice may be a consequence of insufficient expression of interferon regulatory factor 8 (show IRF8 Antibodies)

  4. FLT3-tandem duplication mutation directly affects dendritic cell development, indirectly modulating T cell homeostasis and supporting T reg (show KCNH2 Antibodies) cell expansion.

  5. MYB (show MYB Antibodies) and C/EBPalpha (show CEBPA Antibodies) activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

  6. functional synergy between Flt3 and IL-4R signaling is critical for Stat (show STAT1 Antibodies)-mediated regulation of sterile gamma1 germ-line transcripts and CSR (show SCARA3 Antibodies) to IgG1

  7. STAT5 (show STAT5A Antibodies) activation by FLT3-ITD protects cells treated with the PI3K/Akt (show AKT1 Antibodies) pathway inhibitors from apoptosis by maintaining Mcl-1 (show MCL1 Antibodies) expression through the mTORC1/4EBP1 (show EIF4EBP1 Antibodies)/eIF4E (show EIF4E Antibodies) pathway.

  8. LAMTOR2 (show LAMTOR2 Antibodies) has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR (show FRAP1 Antibodies) signalling

  9. The Ras-PI3Kgamma (show PIK3CG Antibodies)-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) signaling axis acts downstream of FLT3L (show FLT3LG Antibodies) signaling and is required for development of lung CD103 (show ITGAE Antibodies)(+)and CD11b (show ITGAM Antibodies)(+) dendritic cells. This signaling network regulating tissue-specific DC development is mediated by FLT3.

  10. These results reveal a leukemic pathway involving FAK (show PTK2 Antibodies)/Tiam1 (show TIAM1 Antibodies)/Rac1/PAK1 (show PAK1 Antibodies) and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 (show STAT5A Antibodies) in leukemogenesis.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Prevalence of FLT3-ITD mutation in acute myeloid leukemia (show BCL11A Antibodies) was present in a proportion comparable to other populations and, when present, was associated with a very poor prognosis.

  2. PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling only occurs when FLT3-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS (show ROS1 Antibodies). ER retention of FLT3-ITD resulted in NOX4 (show NOX4 Antibodies) deglycosylation and p22(phox (show CYBA Antibodies)) protein degradation.

  3. This study evaluated FLT3 internal tandem duplication mutation along with FLT3 expression in acute myeloid leukaemia (AML (show RUNX1 Antibodies)) patients, and associated with survival. Negative impact of FLT3 surface expression on survival was observed in AML (show RUNX1 Antibodies) patients who were FLT3 ITD negative

  4. FLT3 mutation is associated with acute myeloid leukemia (show BCL11A Antibodies).

  5. In vitro, uremia induced dysregulation of DNA methylation (show HELLS Antibodies) in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1 (show HDAC1 Antibodies), MNT (show MNT Antibodies)) and led to enhanced generation of intermediate monocytes.

  6. null variant for neutrophil count) are generalizable to WBC traits in Hispanics/Latinos. We identified and replicated common and rare germ-line variants at FLT3 (a gene often somatically mutated in leukemia) associated with monocyte count. The common FLT3 variant rs76428106 has a large allele frequency differential between African and non-African populations

  7. Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 (show WT1 Antibodies) gene expression in FLT3-positive acute myeloid leukemia (show BCL11A Antibodies).

  8. DNMT3A (show DNMT3A Antibodies) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Antibodies).

  9. Results show that deletion of Dnmt3a (show DNMT3A Antibodies) cooperates with FLT3- internal tandem duplication to initiate both myeloid and lymphoid leukemias.

  10. In pediatric patients with AML (show RUNX1 Antibodies) from Argentina, a favorable prognosis of AML (show RUNX1 Antibodies) with genotype NPM1 (show NPM1 Antibodies)-mutated/FLT3-ITD-negative was confirmed.

FLT3 Antigen Profile

Antigen Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) antibody
  • FMS-like tyrosine kinase 3 (Flt3) antibody
  • fms-related tyrosine kinase 3 (Flt3) antibody
  • B230315G04 antibody
  • CD135 antibody
  • FLK-2 antibody
  • FLK2 antibody
  • Flt-3 antibody
  • FLT3 antibody
  • Ly72 antibody
  • STK1 antibody
  • wmfl antibody

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPECIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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