You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our FLT3 Proteins (FLT3)

Full name:
Fms-Related tyrosine Kinase 3 Proteins (FLT3)
On are 24 Fms-Related tyrosine Kinase 3 (FLT3) Proteins from 7 different suppliers available. Additionally we are shipping FLT3 Antibodies (336) and FLT3 Kits (30) and many more products for this protein. A total of 400 FLT3 products are currently listed.
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all proteins Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
Rat FLT3 FLT3 140635  

Show all synonyms

FLT3 Proteins (FLT3) by Origin

Select your origin of interest

More Proteins for FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. increased number of osteoclasts in Flt3L (show FLT3LG Proteins)(-/-) mice may be a consequence of insufficient expression of interferon regulatory factor 8 (show IRF8 Proteins)

  2. FLT3-tandem duplication mutation directly affects dendritic cell development, indirectly modulating T cell homeostasis and supporting T reg (show KCNH2 Proteins) cell expansion.

  3. MYB (show MYB Proteins) and C/EBPalpha (show CEBPA Proteins) activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

  4. functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1

  5. STAT5 (show STAT5A Proteins) activation by FLT3-ITD protects cells treated with the PI3K/Akt (show AKT1 Proteins) pathway inhibitors from apoptosis by maintaining Mcl-1 (show MCL1 Proteins) expression through the mTORC1/4EBP1 (show EIF4EBP1 Proteins)/eIF4E (show EIF4E Proteins) pathway.

  6. LAMTOR2 (show LAMTOR2 Proteins) has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR (show FRAP1 Proteins) signalling

  7. The Ras-PI3Kgamma (show PIK3CG Proteins)-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling axis acts downstream of FLT3L (show FLT3LG Proteins) signaling and is required for development of lung CD103 (show ITGAE Proteins)(+)and CD11b (show ITGAM Proteins)(+) dendritic cells. This signaling network regulating tissue-specific DC development is mediated by FLT3.

  8. These results reveal a leukemic pathway involving FAK (show PTK2 Proteins)/Tiam1 (show TIAM1 Proteins)/Rac1/PAK1 (show PAK1 Proteins) and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 (show STAT5A Proteins) in leukemogenesis.

  9. Accumulation of FLT3(+) CD11c (show ITGAX Proteins) (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor

  10. Hes1 suppresses acute myeloid leukemia (show BCL11A Proteins) development through FLT3 repression.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. This study investigated the expression level of miR-1 (show FSD1 Proteins), miR (show MLXIP Proteins)-486, and let-7a in 45 CN-AML (show RUNX1 Proteins) patients well characterized for FLT3 and/or NPM1 (show NPM1 Proteins) mutations using real-time quantitative RT-PCR and evaluated the association between candidate miRs expression and clinical features

  2. Cabozantinib is selectively cytotoxic to leukemia cells with FLT3-ITD, causing cell-cycle arrest and apoptosis.

  3. The prevalence of FLT3 heterozygous mutations is more that homozygous mutations in AML (show RUNX1 Proteins) patients.

  4. FLT3-ITD mutations were found in 10 patients.

  5. results identify CDC25C (show CDC25C Proteins) as a downstream target of the mutated tyrosine kinase (show TXK Proteins) FLT3-ITD affecting cell-cycle regulation in a model of AML (show RUNX1 Proteins)

  6. FLT3 mutation is not frequent in Acute Myeloid Leukemia (show BCL11A Proteins) in Pakistan.

  7. Data show that fyn proto-oncogene (show FYN Proteins) protein (FYN (show FYN Proteins)) expression is deregulated in acute myeloid leukemia (show BCL11A Proteins) and that higher expression of FYN (show FYN Proteins), in combination with FLT3 protein-ITD mutation, resulted in enrichment of the STAT5 (show STAT5A Proteins) transcription factor signaling.

  8. Normal FLT3 and negative expression of CD34 (show CD34 Proteins) and cMPL (show MPL Proteins) may predict a longer overall survival in aute myeloid leukemia (show BCL11A Proteins).

  9. This study suggests that residual disease shows prognostic relevance in pediatric patients with intermediate risk cytogenetics and negative FLT3-ITD acute myeloid leukemia (show BCL11A Proteins).

  10. These data demonstrate high risk of early relapse after allogeneic HCT for FLT3-mutated AML (show RUNX1 Proteins) that translates into adverse disease-free and overall survival outcomes.

FLT3 Protein Profile

Protein Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3)
  • FMS-like tyrosine kinase 3 (Flt3)
  • fms-related tyrosine kinase 3 (Flt3)
  • B230315G04 protein
  • CD135 protein
  • FLK-2 protein
  • FLK2 protein
  • Flt-3 protein
  • FLT3 protein
  • Ly72 protein
  • STK1 protein
  • wmfl protein

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
Selected quality suppliers for FLT3 Proteins (FLT3)
Did you look for something else?