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Browse our FLT3 Proteins (FLT3)

Full name:
Fms-Related tyrosine Kinase 3 Proteins (FLT3)
On are 26 Fms-Related tyrosine Kinase 3 (FLT3) Proteins from 8 different suppliers available. Additionally we are shipping FLT3 Antibodies (351) and FLT3 Kits (39) and many more products for this protein. A total of 427 FLT3 products are currently listed.
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all proteins Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
Rat FLT3 FLT3 140635  

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FLT3 Proteins (FLT3) by Origin

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Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (show TYRO3 Proteins) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  2. DNMT3A (show DNMT3A Proteins) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Proteins).

  3. murine Fms-like tyrosine kinase 3 (Flt3) ligand (show FLT3LG Proteins) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (show SLC11A1 Proteins)) infection in vitro.

  4. increased number of osteoclasts in Flt3L (show FLT3LG Proteins)(-/-) mice may be a consequence of insufficient expression of interferon regulatory factor 8 (show IRF8 Proteins)

  5. FLT3-tandem duplication mutation directly affects dendritic cell development, indirectly modulating T cell homeostasis and supporting T reg (show KCNH2 Proteins) cell expansion.

  6. MYB (show MYB Proteins) and C/EBPalpha (show CEBPA Proteins) activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

  7. functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1

  8. STAT5 (show STAT5A Proteins) activation by FLT3-ITD protects cells treated with the PI3K/Akt (show AKT1 Proteins) pathway inhibitors from apoptosis by maintaining Mcl-1 (show MCL1 Proteins) expression through the mTORC1/4EBP1 (show EIF4EBP1 Proteins)/eIF4E (show EIF4E Proteins) pathway.

  9. LAMTOR2 (show LAMTOR2 Proteins) has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR (show FRAP1 Proteins) signalling

  10. The Ras-PI3Kgamma (show PIK3CG Proteins)-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling axis acts downstream of FLT3L (show FLT3LG Proteins) signaling and is required for development of lung CD103 (show ITGAE Proteins)(+)and CD11b (show ITGAM Proteins)(+) dendritic cells. This signaling network regulating tissue-specific DC development is mediated by FLT3.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Prevalence of FLT3-ITD mutation in acute myeloid leukemia (show BCL11A Proteins) was present in a proportion comparable to other populations and, when present, was associated with a very poor prognosis.

  2. PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling only occurs when FLT3-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS (show ROS1 Proteins). ER retention of FLT3-ITD resulted in NOX4 (show NOX4 Proteins) deglycosylation and p22(phox (show CYBA Proteins)) protein degradation.

  3. This study evaluated FLT3 internal tandem duplication mutation along with FLT3 expression in acute myeloid leukaemia (AML (show RUNX1 Proteins)) patients, and associated with survival. Negative impact of FLT3 surface expression on survival was observed in AML (show RUNX1 Proteins) patients who were FLT3 ITD negative

  4. FLT3 mutation is associated with acute myeloid leukemia (show BCL11A Proteins).

  5. In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes.

  6. null variant for neutrophil count) are generalizable to WBC traits in Hispanics/Latinos. We identified and replicated common and rare germ-line variants at FLT3 (a gene often somatically mutated in leukemia) associated with monocyte count. The common FLT3 variant rs76428106 has a large allele frequency differential between African and non-African populations

  7. Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 (show WT1 Proteins) gene expression in FLT3-positive acute myeloid leukemia (show BCL11A Proteins).

  8. DNMT3A (show DNMT3A Proteins) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Proteins).

  9. Results show that deletion of Dnmt3a (show DNMT3A Proteins) cooperates with FLT3- internal tandem duplication to initiate both myeloid and lymphoid leukemias.

  10. In pediatric patients with AML (show RUNX1 Proteins) from Argentina, a favorable prognosis of AML (show RUNX1 Proteins) with genotype NPM1 (show NPM1 Proteins)-mutated/FLT3-ITD-negative was confirmed.

FLT3 Protein Profile

Protein Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3)
  • FMS-like tyrosine kinase 3 (Flt3)
  • fms-related tyrosine kinase 3 (Flt3)
  • B230315G04 protein
  • CD135 protein
  • FLK-2 protein
  • FLK2 protein
  • Flt-3 protein
  • FLT3 protein
  • Ly72 protein
  • STK1 protein
  • wmfl protein

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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