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Browse our FLT3 Proteins (FLT3)

Full name:
Fms-Related tyrosine Kinase 3 Proteins (FLT3)
On are 24 Fms-Related tyrosine Kinase 3 (FLT3) Proteins from 8 different suppliers available. Additionally we are shipping FLT3 Antibodies (327) and FLT3 Kits (32) and many more products for this protein. A total of 393 FLT3 products are currently listed.
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all proteins Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
Rat FLT3 FLT3 140635  

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FLT3 Proteins (FLT3) by Origin

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More Proteins for FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. increased number of osteoclasts in Flt3L (show FLT3LG Proteins)(-/-) mice may be a consequence of insufficient expression of interferon regulatory factor 8 (show IRF8 Proteins)

  2. FLT3-tandem duplication mutation directly affects dendritic cell development, indirectly modulating T cell homeostasis and supporting T reg (show KCNH2 Proteins) cell expansion.

  3. MYB (show MYB Proteins) and C/EBPalpha (show CEBPA Proteins) activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

  4. functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1

  5. STAT5 (show STAT5A Proteins) activation by FLT3-ITD protects cells treated with the PI3K/Akt (show AKT1 Proteins) pathway inhibitors from apoptosis by maintaining Mcl-1 (show MCL1 Proteins) expression through the mTORC1/4EBP1 (show EIF4EBP1 Proteins)/eIF4E (show EIF4E Proteins) pathway.

  6. LAMTOR2 (show LAMTOR2 Proteins) has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR (show FRAP1 Proteins) signalling

  7. The Ras-PI3Kgamma (show PIK3CG Proteins)-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling axis acts downstream of FLT3L (show FLT3LG Proteins) signaling and is required for development of lung CD103 (show ITGAE Proteins)(+)and CD11b (show ITGAM Proteins)(+) dendritic cells. This signaling network regulating tissue-specific DC development is mediated by FLT3.

  8. These results reveal a leukemic pathway involving FAK (show PTK2 Proteins)/Tiam1 (show TIAM1 Proteins)/Rac1/PAK1 (show PAK1 Proteins) and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 (show STAT5A Proteins) in leukemogenesis.

  9. Accumulation of FLT3(+) CD11c (show ITGAX Proteins) (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor

  10. Hes1 suppresses acute myeloid leukemia (show BCL11A Proteins) development through FLT3 repression.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. BTK (show BTK Proteins) RNA interference inhibits proliferation of FLT3-ITD acute myeloid leukemia (show BCL11A Proteins) cells.

  2. Identify CDC25A (show CDC25A Proteins) as an early cell cycle transducer of FLT3-ITD oncogenic signaling, and as a promising target to inhibit proliferation and re-induce differentiation of FLT3-ITD acute myeloid leukemia (show BCL11A Proteins) cells.

  3. Molecular docking studies suggest the involvement of Leu616, Asp698, Cys694 and Cys828 residues in binding of G-11 to FLT3. The ability of G-11 to cause selective cytotoxicity and induce differentiation in cancer cells could be clinically relevant

  4. Mutations in FLT3 internal tandem duplication is associated with Acute Myeloid Leukemia (show BCL11A Proteins).

  5. Retroviral expression of FLT3-N676K in myeloid 32D cells induced AML (show RUNX1 Proteins) in syngeneic C3H/HeJ mice. 3 of 14 C57BL/6J mice transplanted with FLT3-N676K-transduced primary hematopoietic progenitor cells developed acute leukemia.

  6. Nox4 (show NOX4 Proteins) knockout (Nox4 (show NOX4 Proteins)(-/-)) murine hematopoietic progenitor cells were refractory to FLT3ITD-mediated transformation in vitro

  7. E6201 markedly reduced leukemia burden and improved the survival of mice in a human FLT3-mutated AML (show RUNX1 Proteins) model.

  8. Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML (show RUNX1 Proteins) cells.

  9. Results show FLT3, NPM1 (show NPM1 Proteins), and CEBPA (show CEBPA Proteins) combination genotype confer favourable prognosis in AML (show RUNX1 Proteins)

  10. loss of BEX1 (show BEX1 Proteins) expression in FLT3-ITD driven AML (show RUNX1 Proteins) potentiates oncogenic signaling and leads to decreased overall survival

FLT3 Protein Profile

Protein Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3)
  • FMS-like tyrosine kinase 3 (Flt3)
  • fms-related tyrosine kinase 3 (Flt3)
  • B230315G04 protein
  • CD135 protein
  • FLK-2 protein
  • FLK2 protein
  • Flt-3 protein
  • FLT3 protein
  • Ly72 protein
  • STK1 protein
  • wmfl protein

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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