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Browse our FLT3 Proteins (FLT3)

Full name:
Fms-Related tyrosine Kinase 3 Proteins (FLT3)
On are 25 Fms-Related tyrosine Kinase 3 (FLT3) Proteins from 7 different suppliers available. Additionally we are shipping FLT3 Antibodies (344) and FLT3 Kits (36) and many more products for this protein. A total of 415 FLT3 products are currently listed.
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all proteins Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
Rat FLT3 FLT3 140635  

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FLT3 Proteins (FLT3) by Origin

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More Proteins for FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. DNMT3A (show DNMT3A Proteins) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Proteins).

  2. murine Fms-like tyrosine kinase 3 (Flt3) ligand (show FLT3LG Proteins) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (show SLC11A1 Proteins)) infection in vitro.

  3. increased number of osteoclasts in Flt3L (show FLT3LG Proteins)(-/-) mice may be a consequence of insufficient expression of interferon regulatory factor 8 (show IRF8 Proteins)

  4. FLT3-tandem duplication mutation directly affects dendritic cell development, indirectly modulating T cell homeostasis and supporting T reg (show KCNH2 Proteins) cell expansion.

  5. MYB (show MYB Proteins) and C/EBPalpha (show CEBPA Proteins) activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

  6. functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1

  7. STAT5 (show STAT5A Proteins) activation by FLT3-ITD protects cells treated with the PI3K/Akt (show AKT1 Proteins) pathway inhibitors from apoptosis by maintaining Mcl-1 (show MCL1 Proteins) expression through the mTORC1/4EBP1 (show EIF4EBP1 Proteins)/eIF4E (show EIF4E Proteins) pathway.

  8. LAMTOR2 (show LAMTOR2 Proteins) has a role in regulating dendritic cell homeostasis through FLT3-dependent mTOR (show FRAP1 Proteins) signalling

  9. The Ras-PI3Kgamma (show PIK3CG Proteins)-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling axis acts downstream of FLT3L (show FLT3LG Proteins) signaling and is required for development of lung CD103 (show ITGAE Proteins)(+)and CD11b (show ITGAM Proteins)(+) dendritic cells. This signaling network regulating tissue-specific DC development is mediated by FLT3.

  10. These results reveal a leukemic pathway involving FAK (show PTK2 Proteins)/Tiam1 (show TIAM1 Proteins)/Rac1/PAK1 (show PAK1 Proteins) and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 (show STAT5A Proteins) in leukemogenesis.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 (show WT1 Proteins) gene expression in FLT3-positive acute myeloid leukemia (show BCL11A Proteins).

  2. DNMT3A (show DNMT3A Proteins) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Proteins).

  3. Results show that deletion of Dnmt3a (show DNMT3A Proteins) cooperates with FLT3- internal tandem duplication to initiate both myeloid and lymphoid leukemias.

  4. In pediatric patients with AML (show RUNX1 Proteins) from Argentina, a favorable prognosis of AML (show RUNX1 Proteins) with genotype NPM1 (show NPM1 Proteins)-mutated/FLT3-ITD-negative was confirmed.

  5. In FLT3-ITD mutated AML RIPK3 and MLKL expression is reduced. This leads to reduced necroptosis, inflammasome activation and more aggressive disease.

  6. Gelatin-coated Gold Nanoparticles as Carriers of FLT3 Inhibitors for Acute Myeloid Leukemia (show BCL11A Proteins) Treatment.

  7. introduce the combined use of CD25 (show IL2RA Proteins) and properly strati fi ed CD135 values as alternatives to testing for the FLT3-ITD mutation

  8. This study investigated the expression level of miR-1 (show FSD1 Proteins), miR (show MLXIP Proteins)-486, and let-7a in 45 CN-AML (show RUNX1 Proteins) patients well characterized for FLT3 and/or NPM1 (show NPM1 Proteins) mutations using real-time quantitative RT-PCR and evaluated the association between candidate miRs expression and clinical features

  9. Cabozantinib is selectively cytotoxic to leukemia cells with FLT3-ITD, causing cell-cycle arrest and apoptosis.

  10. The prevalence of FLT3 heterozygous mutations is more that homozygous mutations in AML (show RUNX1 Proteins) patients.

FLT3 Protein Profile

Protein Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3)
  • FMS-like tyrosine kinase 3 (Flt3)
  • fms-related tyrosine kinase 3 (Flt3)
  • B230315G04 protein
  • CD135 protein
  • FLK-2 protein
  • FLK2 protein
  • Flt-3 protein
  • FLT3 protein
  • Ly72 protein
  • STK1 protein
  • wmfl protein

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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