Browse our FLT3 Proteins (FLT3)

Full name:
Fms-Related tyrosine Kinase 3 Proteins (FLT3)
On www.antibodies-online.com are 26 Fms-Related tyrosine Kinase 3 (FLT3) Proteins from 8 different suppliers available. Additionally we are shipping FLT3 Antibodies (355) and FLT3 Kits (39) and many more products for this protein. A total of 431 FLT3 products are currently listed.
Synonyms:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl
list all proteins Gene Name GeneID UniProt
FLT3 14255 Q00342
FLT3 2322 P36888
Rat FLT3 FLT3 140635  

Show all synonyms

FLT3 Proteins (FLT3) by Origin

Select your origin of interest

More Proteins for FLT3 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. the Hoxa9 (show HOXA9 Proteins)- and Meis1 (show MEIS1 Proteins)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (show RUNX1 Proteins) pathology.

  2. lineage-specific STAT5 (show STAT5A Proteins) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  3. DOCK2 is a potential therapeutic target for novel AML (show RUNX1 Proteins) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Used a genetic model to determine whether miR (show MLXIP Proteins)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (show MLXIP Proteins)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (show MLXIP Proteins)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (show IFNA Proteins) response.

  5. Overexpression of Abl (show ABL1 Proteins)-related gene tyrosine kinase (show TYRO3 Proteins) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  6. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  7. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 (show PBX1 Proteins) axis

  8. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (show TYRO3 Proteins) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  9. DNMT3A (show DNMT3A Proteins) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Proteins).

  10. murine Fms-like tyrosine kinase 3 (Flt3) ligand (show FLT3LG Proteins) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (show SLC11A1 Proteins)) infection in vitro.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Y842 is critical for FLT3-mediated RAS/ERK (show EPHB2 Proteins) signaling and cellular transformation.

  2. value of FLT3-ITD allelic ratio in AML (show RUNX1 Proteins) in risk assessment and evaluating prognosis

  3. DOCK2 is a potential therapeutic target for novel AML (show RUNX1 Proteins) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (show PIK3CA Proteins)/mTOR (show FRAP1 Proteins) pathway in FLT3-ITD-dependent AML (show RUNX1 Proteins) results in resistance to drugs targeting FLT3.

  5. HHEX (show HHEX Proteins) could replace RUNX1 (show RUNX1 Proteins) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).

  6. mutated FLT3-ITD and JAK2 (show JAK2 Proteins) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  7. these data reveal a novel mechanism which regulates acute myeloid leukemia (show BCL11A Proteins) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  8. MSI2 (show MSI2 Proteins) and FLT3 are significantly co-regulated in human AML (show RUNX1 Proteins)

  9. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  10. Factors that did not influence the relapse risk included: age, graft type, graft source, type of FLT3 mutation, or conditioning intensity

FLT3 Protein Profile

Protein Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3)
  • FMS-like tyrosine kinase 3 (Flt3)
  • fms-related tyrosine kinase 3 (Flt3)
  • B230315G04 protein
  • CD135 protein
  • FLK-2 protein
  • FLK2 protein
  • Flt-3 protein
  • FLT3 protein
  • Ly72 protein
  • STK1 protein
  • wmfl protein

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPECIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
Selected quality suppliers for FLT3 Proteins (FLT3)
Did you look for something else?