FLT3 Protein (AA 27-543) (Fc Tag)
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- Target See all FLT3 Proteins
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 27-543
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FLT3 protein is labelled with Fc Tag.
- Sequence
- AA 27-543
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FLT3 Protein
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Fms-Related tyrosine Kinase 3 (FLT3) (AA 27-541) protein (Fc Tag)
FLT3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 3 (FLT3) (AA 28-541) protein (Fc Tag)FLT3 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related tyrosine Kinase 3 (FLT3) (AA 28-544) protein (Fc Tag)FLT3 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 3 (FLT3) (AA 27-543) protein (Fc-His Tag)FLT3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Fms-Related tyrosine Kinase 3 (FLT3) (AA 91-190) protein (GST tag)FLT3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fms-Related tyrosine Kinase 3 (FLT3) protein (His tag)FLT3 Origin: Mouse Host: HEK-293 Cells Recombinant > 75 % as determined by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Alternative Name
- Flt-3 (FLT3 Products)
- Synonyms
- FLT3 Protein, B230315G04 Protein, CD135 Protein, Flk-2 Protein, Flk2 Protein, Flt-3 Protein, Ly72 Protein, wmfl Protein, FLK-2 Protein, FLK2 Protein, STK1 Protein, fms related tyrosine kinase 3 Protein, FMS-like tyrosine kinase 3 Protein, fms-related tyrosine kinase 3 Protein, FLT3 Protein, Flt3 Protein
- Background
- Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Molecular Weight
- 84.8 kDa
- NCBI Accession
- NP_004110
- Pathways
- RTK Signaling
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