FLT3 Protein (AA 27-543) (Fc Tag)

Catalog No. ABIN6809860

Product Details

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 27-543

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FLT3 protein is labelled with Fc Tag.

Sequence: AA 27-543

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: Flt-3 (FLT3 Products)

Synonyms: FLT3 Protein, B230315G04 Protein, CD135 Protein, Flk-2 Protein, Flk2 Protein, Flt-3 Protein, Ly72 Protein, wmfl Protein, FLK-2 Protein, FLK2 Protein, STK1 Protein, fms related tyrosine kinase 3 Protein, FMS-like tyrosine kinase 3 Protein, fms-related tyrosine kinase 3 Protein, FLT3 Protein, Flt3 Protein

Background: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Molecular Weight: 84.8 kDa

NCBI Accession: NP_004110

Pathways: RTK Signaling