FLT3 Protein (AA 27-543) (Fc Tag)

Catalog No. ABIN6809860

Recombinant FLT3 protein expressed in HEK-293 Cells.

Quick Overview for FLT3 Protein (AA 27-543) (Fc Tag) (ABIN6809860)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 27-543

Purification tag / Conjugate: This FLT3 protein is labelled with Fc Tag.

Sequence: AA 27-543

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: Flt-3

Background: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Molecular Weight: 84.8 kDa

NCBI Accession: NP_004110

Pathways: RTK Signaling