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Human FLT3LG Protein expressed in HEK-293 Cells - ABIN2181110
Kalberer, Siegler, Wodnar-Filipowicz: Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells. in Blood 2003
Show all 2 references for ABIN2181110
Human FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN413275
Staron, Yang, Liu, Li, Shen, Zúñiga-Pflücker, Aguila, Goldschneider, Li: gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. in Blood 2010
Mouse (Murine) FLT3LG Protein expressed in Human Cells - ABIN2008636
Hannum, Culpepper, Campbell, McClanahan, Zurawski, Bazan, Kastelein, Hudak, Wagner, Mattson: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. in Nature 1994
Mouse (Murine) FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN809712
McCoy, Golden, Doll, Yang, Kaba, Burkhard, Lanar: Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. in Malaria journal 2013
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L.
Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (show CSF3 Proteins), Flt3 (show FLT3 Proteins)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
Study showed shown Flt3L-dependent accumulation of a population of DNGR-1(CLEC9A (show CLEC9A Proteins))-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain
Data indicate that Flt3 ligand knockout (Flt3L-/-) mice are unable to control infection with Toxoplasma gondii.
inhibition of the calcineurin (show PPP3CA Proteins)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
The Cx3cr1 (show CX3CR1 Proteins)(gfp/+)Flt3L(-/-) reporter mouse model represents a powerful tool to visualize monocyte activities in bone marrow.
Flt3L(-/-) mice showed a marked decrease in clinical arthritis scores and incidence of arthritis in both acute and chronic phases of CIA (show NCOA5 Proteins) compared with WT mice. Moreover, decreased synovial inflammation and joint destruction was observed.
Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells
Here, we build on the observation that Langerin (show CD207 Proteins)-CD11b (show ITGAM Proteins)- migrating dendritic cells are Flt3L dependent and strongly Flt3L responsive, which may relate them to classical dendritic cells.
Pre-treatment serum levels of FLT3 (show FLT3 Proteins)-L were higher than controls. FLT3 (show FLT3 Proteins)-L correlated positively with all soluble angiogenic factors, as well with bone marrow microvascular density. Post-treatment FLT3 (show FLT3 Proteins)-L decreased significantly in responders to therapy.
The immunohistochemical expression of caveolin-1 (show CAV1 Proteins) and podocalyxin (show PODXL Proteins) in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
The Flt3L/CD135 (show FLT3 Proteins) axis is active in rheumatoid arthritis
Administration of the hematopoietic growth factor (show Il3 Proteins) Flt3L to human subjects increases the frequency and absolute number of Treg cells.
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE (show LIPF Proteins)(2) signaling through EP1 (show PTGER1 Proteins)/EP3 (show PTGER3 Proteins) receptors regulates Flt3 (show FLT3 Proteins) expression and downstream STAT3 (show STAT3 Proteins) activation and survivin (show BIRC5 Proteins) expression, required for optimal progenitor survival and differentiation.
data demonstrate that the Flt3L/TK gene therapeutic approach can induce systemic immunological memory capable of recognizing a brain tumor neoantigen in a model of recurrent GBM
FLT3 ligand(FL) leads to further activation of FLT3 (show FLT3 Proteins) mutants and is especially important in light of recent findings of elevated FL levels in acute myeloid leukemia (show BCL11A Proteins) patients in response to chemotherapy.
FLT3 ligand impedes the efficacy of FLT3 (show FLT3 Proteins) inhibitors in vitro and in vivo.
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE\; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010
, flt3 ligand
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand