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anti-Mouse (Murine) GAS6 Antibodies:
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Human Polyclonal GAS6 Primary Antibody for IHC, ELISA - ABIN1533886
Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. in Nature 1995
Human Polyclonal GAS6 Primary Antibody for IHC, IHC (p) - ABIN4313581
Pinato, Mauri, Lloyd, Vaira, Casadio, Boldorini, Sharma: The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma. in British journal of cancer 2013
Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 (show MAPK1/3 Antibodies) signaling.
Gas6/Axl (show AXL Antibodies) and Akt (show AKT1 Antibodies)/FoxO1a (show FOXO1 Antibodies) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Antibodies) signaling axis plays an important role in VCAM-1 (show VCAM1 Antibodies) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Antibodies) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Antibodies)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Antibodies) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Antibodies) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway.
The up-regulation of Gas6/Axl (show AXL Antibodies) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3 (show TYRO3 Antibodies), Axl (show AXL Antibodies), and Mer (show ERH Antibodies) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH Antibodies) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
Data show that the variant growth arrest specific 6 (GAS6) +1332 T allele is associated with a decreased risk for severe preeclampsia in a South West Han Chinese population, but the 834+7G/A polymorphism has no effect on the severe preeclampsia.
Gas6 plasma level within 24 hours of ICU admission may predicts in-ICU mortality in patients with sepsis
Taken together, these results indicate that E2 exerts inhibitory effects on VSMC apoptosis and calcification through ERalpha (show ESR1 Antibodies)-mediated Gas6 transactivation. These findings indicate a potential therapeutic strategy for the prevention of vascular calcification, especially in postmenopausal women.
In this paper, we review the biology of the Gas6/Tyro3 (show TYRO3 Antibodies), Axl (show AXL Antibodies), and MerTK (show MERTK Antibodies)(collectively named TAM (show CCNA1 Antibodies) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
serum testosterone and GAS6 levels were positively associated in male patients with coronary heart disease
investigation of the prognostic values of stromal NK cells and Gas6 in triple negative breast cancer (TNBC), and to eventually establish a prognostic risk model for patients with TNBC
CONCLUSIONS: Our results suggest that GAS6 c.834 + 7G> A polymorphism may have a pivotal role in the pathogenesis of preeclampsia (PE) suggesting that the A allele has a protective role for PE.
High expression of Gas6 correlated with Upper Tract Urothelial Carcinoma.
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor