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anti-Mouse (Murine) GAS6 Antibodies:
anti-Rat (Rattus) GAS6 Antibodies:
anti-Human GAS6 Antibodies:
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Human Polyclonal GAS6 Primary Antibody for IHC, ELISA - ABIN1533886
Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. in Nature 1995
Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 (show MAPK1/3 Antibodies) signaling.
Gas6/Axl (show AXL Antibodies) and Akt (show AKT1 Antibodies)/FoxO1a (show FOXO1 Antibodies) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Antibodies) signaling axis plays an important role in VCAM-1 (show VCAM1 Antibodies) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Antibodies) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Antibodies)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Antibodies) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Antibodies) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway.
The up-regulation of Gas6/Axl (show AXL Antibodies) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3 (show TYRO3 Antibodies), Axl (show AXL Antibodies), and Mer (show ERH Antibodies) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH Antibodies) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
CONCLUSIONS: Our results suggest that GAS6 c.834 + 7G> A polymorphism may have a pivotal role in the pathogenesis of preeclampsia (PE) suggesting that the A allele has a protective role for PE.
High expression of Gas6 correlated with Upper Tract Urothelial Carcinoma.
GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
decreased plasma Gas6 concentration and labial (show LAT2 Antibodies) salivary gland expression were associated with primary Sjogren syndrome(pSS (show CDSN Antibodies)); Gas6 may represent a novel independent risk factor for pSS (show CDSN Antibodies), with a potential role in salivary gland inflammation and dysfunction
Gas6 increases the metastatic capacity of oral squamous cell carcinoma(OSCC) cells and serum Gas6 could be a candidate biomarker for diagnostic and prognostic use in OSCC patients.
Gas6 gene variants are associated with IR, although their effects on subsequent progression to T2D were minimal in this prospective Asian cohort
Data shoed increased GAS6 and decreased MGP (show MGP Antibodies) levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor