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anti-Mouse (Murine) GAS6 Antibodies:
anti-Rat (Rattus) GAS6 Antibodies:
anti-Human GAS6 Antibodies:
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Human Polyclonal GAS6 Primary Antibody for IHC, ELISA - ABIN1533886
Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. in Nature 1995
Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 (show MAPK1/3 Antibodies) signaling.
Gas6, through upregulation of Ptges (show PTGES Antibodies)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Antibodies) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Antibodies) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway.
The up-regulation of Gas6/Axl (show AXL Antibodies) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3 (show TYRO3 Antibodies), Axl (show AXL Antibodies), and Mer (show ERH Antibodies) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH Antibodies) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
data are consistent with Growth arrest-specific protein 6 being neuroprotective during experimental autoimmune encephalomyelitis by dampening the inflammatory response, thereby preserving axonal integrity and myelination.
These results demonstrate that Gas6 enhances several features of fungal allergic airway disease.
The expression of TAM (show CCNA1 Antibodies) receptor tyrosine kinases and their ligand Gas6 is markedly downregulated in psoriatic epidermis. These data are in concordance with earlier study, demonstrating that TAM (show CCNA1 Antibodies)-deficient mice develop systemic autoimmunity.
Gas6 deficiency enhanced mouse colitis-associated tumorigenesis.
GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
decreased plasma Gas6 concentration and labial (show LAT2 Antibodies) salivary gland expression were associated with primary Sjogren syndrome(pSS (show CDSN Antibodies)); Gas6 may represent a novel independent risk factor for pSS (show CDSN Antibodies), with a potential role in salivary gland inflammation and dysfunction
Gas6 increases the metastatic capacity of oral squamous cell carcinoma(OSCC) cells and serum Gas6 could be a candidate biomarker for diagnostic and prognostic use in OSCC patients.
Gas6 gene variants are associated with IR, although their effects on subsequent progression to T2D were minimal in this prospective Asian cohort
Data shoed increased GAS6 and decreased MGP (show MGP Antibodies) levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.
genetic variability of GAS6 and PEAR1 (show PEAR1 Antibodies) genes may be associated with platelet hyperaggregability
Suggest an association between low plasma GAS6 levels and conventional cardiometabolic risk factors in psoriasis.
a protective role for AA Gas6 variant in type 2 diabetic patients may be concluded
These results suggest that plasma Gas6 is associated with sex hormones in both pre- and postmenopausal women
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor