Browse our GDNF Proteins (GDNF)

Full name:
Glial Cell Derived Neurotrophic Factor Proteins (GDNF)
On www.antibodies-online.com are 1 Glial Cell Derived Neurotrophic Factor (GDNF) Proteins from 1 different suppliers available. Additionally we are shipping GDNF Kits (4) and GDNF Antibodies (1) and many more products for this protein. A total of 6 GDNF products are currently listed.
Synonyms:
AI385739, ATF1, ATF2, gdnf, gdnfa, HFB1-GDNF, HSCR3
list all proteins Gene Name GeneID UniProt
GDNF 2668 P39905
Rat GDNF GDNF 25453 Q07731
Mouse GDNF GDNF 14573 P48540

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GDNF Proteins (GDNF) by Origin

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More Proteins for GDNF Interaction Partners

Rhesus Monkey Glial Cell Derived Neurotrophic Factor (GDNF) interaction partners

  1. Analysis of striatal brain samples confirms increased GDNF expression in lentiviral vector-GDNF treated aged animals that correlates with functional improvements and preserved dopaminergic markers, dependent upon GDNF levels.

Xenopus laevis Glial Cell Derived Neurotrophic Factor (GDNF) interaction partners

  1. Spatial expression analysis by whole-mount in situ hybridization showed that the GDNF mRNA was predominantly detected in somites, pronephros, pharyngeal arches, epibranchial placodes, digestive tract and some of the lateral line structure.

Human Glial Cell Derived Neurotrophic Factor (GDNF) interaction partners

  1. there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing

  2. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  3. In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.

  4. Suppression of miR (show MLXIP Proteins)-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.

  5. Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.

  6. No correlations between the levels of serum neurotrophins and the severity of ADHD were observed. These results suggest that elevated serum GDNF and NTF3 (show NTF3 Proteins) levels may be related to ADHD in children.

  7. BDNF (show BDNF Proteins) and GDNF interact with the 5-HT (show DDC Proteins)-system of the brain through feedback mechanisms engaged in autoregulation

  8. the synergistic effect of Gas1 (show GAS1 Proteins) inhibition and GDNF against glutamate (show GRIN1 Proteins)-induced cell injury in human SH-SY5Y neuroblastoma (show ARHGEF16 Proteins) cells, is reported.

  9. Study shows no correlation between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus.

  10. These results demonstrate the pivotal role of GDNF as well as the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway, but not the MAPK (show MAPK1 Proteins) pathway, in the prevention of diabetesinduced neuronal apoptosis in the hippocampus.

Zebrafish Glial Cell Derived Neurotrophic Factor (GDNF) interaction partners

  1. the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos (show NOS1 Proteins)) mRNA expression in various regions of zebrafish brain

  2. GDNF family ligands including tyrosine kinase receptor (show KDR Proteins) RET (show RET Proteins) are investigated within the adult zebrafish brain.

  3. GDNF is a major determinant of directed neuritic growth , and GDNF acts by promoting local neurite outgrowth.

  4. These results demonstrated the expression of the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of GDNF in Purkinje cells.

  5. These results showed that the expression of GDNF is not probably restricted during development but it might be involved in the physiology of adult zebrafish retina.

  6. The expression of glial cell line-derived neurotrophic factor (GDNF) was not restricted to developmental periods but it seems that this factor might be involved in adult zebrafish brain physiology, as observed in mammals.

Mouse (Murine) Glial Cell Derived Neurotrophic Factor (GDNF) interaction partners

  1. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  2. GDNF signals were able to induce the stratified aggregate formation of GFRalpha1 (show GFRA1 Proteins)-positive undifferentiated spermatogonia

  3. Our results show the existence of two subpopulations of peptidergic nociceptors characterized by the presence of CGRP (show CALCA Proteins), one expressing BDNF (show BDNF Proteins) (plus SP), the other expressing GDNF (plus SST (show SST Proteins)), suggesting a different role for these two neurotrophic factors in the discrimination of specific painful stimuli modalities.

  4. The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (show BDNF Proteins) potentially leading to alterations in neural development.

  5. The Gdnf cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of undifferentiated spermatogonia

  6. Our results reveal the role of GDNF in nigrostriatal dopamine system postnatal development and adult function, and highlight the importance of correct spatial expression of GDNF

  7. Mice overexpressing GDNF had significantly reduced P62 (show GTF2H1 Proteins) protein levels suggestive of accelerated autophagy. They also had reduced PPAR-gamma (show PPARG Proteins) and CD36 (show CD36 Proteins) gene expression and protein levels, and lower expression of mRNA coding for enzymes involved lipogenesis.

  8. This study demonstrated that decrease in mRNA level of GDNF in brain in microgravity.

  9. GDNF signaling in the urogenital sinus increases proliferation.

  10. Results show that in the inflamed intestine, smooth muscle proliferation supports the enteric nervous system , and thus its own re-innervation, by expression of GDNF

GDNF Protein Profile

Protein Summary

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

Alternative names and synonyms associated with GDNF

  • glial cell derived neurotrophic factor (GDNF)
  • glial cell derived neurotrophic factor (gdnf-a)
  • glial cell derived neurotrophic factor (Gdnf)
  • glial cell derived neurotrophic factor a (gdnfa)
  • glial cell line derived neurotrophic factor (Gdnf)
  • AI385739 protein
  • ATF1 protein
  • ATF2 protein
  • gdnf protein
  • gdnfa protein
  • HFB1-GDNF protein
  • HSCR3 protein

Protein level used designations for GDNF

glial cell derived neurotrophic factor , glial cell line derived neurotrophic factor , glial cell line-derived neurotrophic factor , glial cell line-derived neurotrophic factor a , xGDNF , ATF , astrocyte-derived trophic factor , glial cell line-derived neurotrophic factor long form , Glial cell line derived neutrophic factor , glial cell-line derived neurotrophic factor , glia-derived neurotrophic growth factor , zGDNF , mGDNF , neurotrophic factor

GENE ID SPECIES
471566 Pan troglodytes
706345 Macaca mulatta
779087 Xenopus laevis
2668 Homo sapiens
395569 Gallus gallus
25453 Rattus norvegicus
489224 Canis lupus familiaris
100322894 Sus scrofa
386587 Bos taurus
101117619 Ovis aries
100067053 Equus caballus
79379 Danio rerio
14573 Mus musculus
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