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Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN2667420
Carnicella, Ron: GDNF--a potential target to treat addiction. in Pharmacology & therapeutics 2009
Show all 5 references for ABIN2667420
Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN1686334
Pelletier, Lagacé, St-Amour, Arsenault, Cisbani, Chabrat, Fecteau, Lévesque, Cicchetti: The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2015
Study shows no correlation between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus.
ApaL1 and Taq1 single nucleotide polymorphisms of the urokinase and VDR (show CYP27B1 Proteins) genes are associated with recurrent urolithiasis in a Caucasian population.
1,25D3 works as a modifier of NF-kappaB (show NFKB1 Proteins)/GPX1 (show GPX1 Proteins)/uPA (show PRAP1 Proteins) expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells
Resveratrol inhibited hypoxia-induced HIF-1alpha (show HIF1A Proteins) protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 Proteins) and MMP2 (show MMP2 Proteins).
Significance of the urokinase-type plasminogen activator (show PLAU Proteins) and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
These findings strongly support the use of uPA (show PRAP1 Proteins)/PAI-1 (show SERPINE1 Proteins) together with clinic-pathological parameters as an evidence-based, clinically relevant and inexpensive decision tool in the routine of a breast center.
These results demonstrate the pivotal role of GDNF as well as the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway, but not the MAPK (show MAPK1 Proteins) pathway, in the prevention of diabetesinduced neuronal apoptosis in the hippocampus.
Increased plasma levels of GDNF were found in untreated attention deficit hyperactivity disorder patients.
Data suggest that enhanced levels of uPA (show PRAP1 Proteins) in breast cancer modulate the mitogenic effects of EGF (show EGF Proteins) which helps to better understand breast cancer pathogenesis.
Results found high levels of uPA (show PRAP1 Proteins) and uPAR (show PLAUR Proteins) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins) axis in an autocrine and paracrine fashion.
The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (show BDNF Proteins) potentially leading to alterations in neural development.
The Gdnf cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of undifferentiated spermatogonia
Our results reveal the role of GDNF in nigrostriatal dopamine system postnatal development and adult function, and highlight the importance of correct spatial expression of GDNF
Mice overexpressing GDNF had significantly reduced P62 (show GTF2H1 Proteins) protein levels suggestive of accelerated autophagy. They also had reduced PPAR-gamma (show PPARG Proteins) and CD36 (show CD36 Proteins) gene expression and protein levels, and lower expression of mRNA coding for enzymes involved lipogenesis.
This study demonstrated that decrease in mRNA level of GDNF in brain in microgravity.
GDNF signaling in the urogenital sinus increases proliferation.
Results show that in the inflamed intestine, smooth muscle proliferation supports the enteric nervous system , and thus its own re-innervation, by expression of GDNF
Parkin (show PARK2 Proteins) and the RET (show RET Proteins) signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars (show EPRS Proteins) compacta dopaminergic neurons and their innervation in the striatum.
expression induced by testosterone in peritubular myoid (show MYO1A Proteins) cells
These data suggest that there are significant changes in the responses to GDNF as spermatogonial stem cells give rise to progenitor spermatogonia.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, Glial cell line derived neutrophic factor
, astrocyte-derived trophic factor
, glial cell line derived neurotrophic factor
, glial cell line-derived neurotrophic factor
, neurotrophic factor
, U-plasminogen activator
, plasminogen activator, urinary
, urokinase-type plasminogen activator