Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN1686334
Pelletier, Lagacé, St-Amour, Arsenault, Cisbani, Chabrat, Fecteau, Lévesque, Cicchetti: The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2015
results contradict previous studies suggesting that mammalian GFRalpha1 (show GFRA1 Proteins) and GDNF cannot bind and activate non-mammalian RET (show RET Proteins) and vice versa
the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain
GDNF family ligands including tyrosine kinase receptor (show KDR Proteins) RET (show RET Proteins) are investigated within the adult zebrafish brain.
GDNF is a major determinant of directed neuritic growth , and GDNF acts by promoting local neurite outgrowth.
These results demonstrated the expression of the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of GDNF in Purkinje cells.
These results showed that the expression of GDNF is not probably restricted during development but it might be involved in the physiology of adult zebrafish retina.
The expression of glial cell line-derived neurotrophic factor (GDNF) was not restricted to developmental periods but it seems that this factor might be involved in adult zebrafish brain physiology, as observed in mammals.
Analysis of striatal brain samples confirms increased GDNF expression in lentiviral vector-GDNF treated aged animals that correlates with functional improvements and preserved dopaminergic markers, dependent upon GDNF levels.
Six2 (show SIX2 Proteins) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 (show SMURF1 Proteins) expression.
Ret (show RET Proteins) is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
identified IFNg (show IFNG Proteins), Neurturin (Nrtn (show NRTN Proteins)), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation (show NEUROD1 Proteins) of Neural Precursor Cells in vivo.
Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.
The GDNF-GFRalpha1 (show GFRA1 Proteins) complex is essential for proper hippocampal circuit development.
In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression
GDNF signals were able to induce the stratified aggregate formation of GFRalpha1 (show GFRA1 Proteins)-positive undifferentiated spermatogonia
Our results show the existence of two subpopulations of peptidergic nociceptors characterized by the presence of CGRP (show CALCA Proteins), one expressing BDNF (show BDNF Proteins) (plus SP), the other expressing GDNF (plus SST (show SST Proteins)), suggesting a different role for these two neurotrophic factors in the discrimination of specific painful stimuli modalities.
The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (show BDNF Proteins) potentially leading to alterations in neural development.
The Gdnf cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of undifferentiated spermatogonia
Spatial expression analysis by whole-mount in situ hybridization showed that the GDNF mRNA was predominantly detected in somites, pronephros, pharyngeal arches, epibranchial placodes, digestive tract and some of the lateral line structure.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
No correlations between the levels of serum neurotrophins and the severity of ADHD were observed. These results suggest that elevated serum GDNF and NTF3 (show NTF3 Proteins) levels may be related to ADHD in children.
BDNF (show BDNF Proteins) and GDNF interact with the 5-HT (show DDC Proteins)-system of the brain through feedback mechanisms engaged in autoregulation
the synergistic effect of Gas1 (show GAS1 Proteins) inhibition and GDNF against glutamate (show GRIN1 Proteins)-induced cell injury in human SH-SY5Y neuroblastoma (show ARHGEF16 Proteins) cells, is reported.
Study shows no correlation between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus.
These results demonstrate the pivotal role of GDNF as well as the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway, but not the MAPK (show MAPK1 Proteins) pathway, in the prevention of diabetesinduced neuronal apoptosis in the hippocampus.
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
, Glial cell line derived neutrophic factor
, astrocyte-derived trophic factor
, glial cell line derived neurotrophic factor
, glial cell line-derived neurotrophic factor
, glial cell line-derived neurotrophic factor long form
, glial cell derived neurotrophic factor
, glial cell-line derived neurotrophic factor
, neurotrophic factor
, glial cell line-derived neurotrophic factor a
, glia-derived neurotrophic growth factor