Browse our GDNF Proteins (GDNF)

Full name:
Glial Cell Line Derived Neurotrophic Factor Proteins (GDNF)
On www.antibodies-online.com are 76 Glial Cell Line Derived Neurotrophic Factor (GDNF) Proteins from 20 different suppliers available. Additionally we are shipping GDNF Antibodies (159) and GDNF Kits (90) and many more products for this protein. A total of 335 GDNF products are currently listed.
Synonyms:
AI385739, ATF, ATF1, ATF2, BDPLT5, GDNF, gdnfa, HFB1-GDNF, HSCR3, QPD, u-PA, UPA, URK
list all proteins Gene Name GeneID UniProt
GDNF 5328 P00749
GDNF 25453 Q07731
GDNF 14573 P48540

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GDNF Proteins (GDNF) by Origin

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Top referenced GDNF Proteins

  1. Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN2667420 : Carnicella, Ron: GDNF--a potential target to treat addiction. in Pharmacology & therapeutics 2009 (PubMed)
    Show all 5 references for 2667420

  2. Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN1686334 : Pelletier, Lagacé, St-Amour, Arsenault, Cisbani, Chabrat, Fecteau, Lévesque, Cicchetti: The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2015 (PubMed)

More Proteins for GDNF Interaction Partners

Human Glial Cell Line Derived Neurotrophic Factor (GDNF) interaction partners

  1. suggest that the low endogenous levels of uPA (show PRAP1 Proteins) in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner

  2. an intricate link between caveolin-1 (show CAV1 Proteins) and Src kinase (show CSK Proteins)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC Proteins) expression through p53 (show TP53 Proteins) and uPA (show PRAP1 Proteins) system-mediated cross-talk, is reported.

  3. there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing

  4. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  5. results show that the uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins)/LRP1 (show LRP1 Proteins) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury

  6. In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.

  7. The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (show MMP9 Proteins) activity and uPA (show PRAP1 Proteins) expression through decreasing of IKK-beta (show IKBKB Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.

  8. Suppression of miR (show MLXIP Proteins)-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.

  9. These studies identify uPA (show PRAP1 Proteins)-dependent de-repression of vegfr1 (show FLT1 Proteins) and vegfr2 (show KDR Proteins) gene transcription through binding to HHEX/PRH (show HHEX Proteins) as a novel mechanism by which uPA (show PRAP1 Proteins) mediates the pro-angiogenic effects of VEGF (show VEGFA Proteins) and identifies a potential new target for control of pathologic angiogenesis.

  10. Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.

Mouse (Murine) Glial Cell Line Derived Neurotrophic Factor (GDNF) interaction partners

  1. identified IFNg (show IFNG Proteins), Neurturin (Nrtn (show NRTN Proteins)), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation (show NEUROD1 Proteins) of Neural Precursor Cells in vivo.

  2. Using an organ culture system for prostate development and Ret (show RET Proteins) mutant mice, we demonstrate that RET (show RET Proteins)-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.

  3. The GDNF-GFRalpha1 (show GFRA1 Proteins) complex is essential for proper hippocampal circuit development.

  4. In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression

  5. GDNF signals were able to induce the stratified aggregate formation of GFRalpha1 (show GFRA1 Proteins)-positive undifferentiated spermatogonia

  6. Our results show the existence of two subpopulations of peptidergic nociceptors characterized by the presence of CGRP (show CALCA Proteins), one expressing BDNF (show BDNF Proteins) (plus SP), the other expressing GDNF (plus SST (show SST Proteins)), suggesting a different role for these two neurotrophic factors in the discrimination of specific painful stimuli modalities.

  7. The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (show BDNF Proteins) potentially leading to alterations in neural development.

  8. The Gdnf cKO males sired up to two litters but became infertile due to collapse of spermatogenesis and loss of undifferentiated spermatogonia

  9. Our results reveal the role of GDNF in nigrostriatal dopamine system postnatal development and adult function, and highlight the importance of correct spatial expression of GDNF

  10. Mice overexpressing GDNF had significantly reduced P62 (show GTF2H1 Proteins) protein levels suggestive of accelerated autophagy. They also had reduced PPAR-gamma (show PPARG Proteins) and CD36 (show CD36 Proteins) gene expression and protein levels, and lower expression of mRNA coding for enzymes involved lipogenesis.

GDNF Protein Profile

Protein Summary

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

Alternative names and synonyms associated with GDNF

  • plasminogen activator, urokinase (PLAU)
  • glial cell derived neurotrophic factor (Gdnf)
  • glial cell derived neurotrophic factor a (gdnfa)
  • glial cell derived neurotrophic factor (GDNF)
  • glial cell line derived neurotrophic factor (Gdnf)
  • glial cell derived neurotrophic factor (gdnf-a)
  • AI385739 protein
  • ATF protein
  • ATF1 protein
  • ATF2 protein
  • BDPLT5 protein
  • GDNF protein
  • gdnfa protein
  • HFB1-GDNF protein
  • HSCR3 protein
  • QPD protein
  • u-PA protein
  • UPA protein
  • URK protein

Protein level used designations for GDNF

U-plasminogen activator , plasminogen activator, urinary , urokinase-type plasminogen activator , ATF , Glial cell line derived neutrophic factor , astrocyte-derived trophic factor , glial cell line derived neurotrophic factor , glial cell line-derived neurotrophic factor , zGDNF , glial cell line-derived neurotrophic factor long form , glial cell derived neurotrophic factor , glial cell-line derived neurotrophic factor , mGDNF , neurotrophic factor , glial cell line-derived neurotrophic factor a , xGDNF , glia-derived neurotrophic growth factor

GENE ID SPECIES
5328 Homo sapiens
25453 Rattus norvegicus
79379 Danio rerio
386587 Bos taurus
395569 Gallus gallus
471566 Pan troglodytes
489224 Canis lupus familiaris
706345 Macaca mulatta
100322894 Sus scrofa
14573 Mus musculus
779087 Xenopus laevis
2668 Homo sapiens
100067053 Equus caballus
101117619 Ovis aries
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