Browse our GRB2 Proteins (GRB2)

Full name:
Growth Factor Receptor-Bound Protein 2 Proteins (GRB2)
On are 23 Growth Factor Receptor-Bound Protein 2 (GRB2) Proteins from 12 different suppliers available. Additionally we are shipping GRB2 Antibodies (158) and GRB2 Kits (29) and many more products for this protein. A total of 219 GRB2 products are currently listed.
AA408164, ASH, EGFRBP-GRB2, grb2, Grb3-3, MST084, MSTP084, NCKAP2, wu:fb18e12, wu:fb34e06, zgc:73077
list all proteins Gene Name GeneID UniProt
GRB2 14784 Q60631
GRB2 81504 P62994
GRB2 2885 P62993

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GRB2 Proteins (GRB2) by Origin

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Top referenced GRB2 Proteins

  1. Human GRB2 Protein expressed in Escherichia coli (E. coli) - ABIN667098 : Weisswange, Newsome, Schleich, Way: The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. in Nature 2009 (PubMed)
    Show all 2 references for 667098

More Proteins for GRB2 Interaction Partners

Mouse (Murine) Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. Two Dtna (show DTNA Proteins) interactors, alpha-catulin (show CTNNAL1 Proteins) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.

  2. Grb2-deficient T cells show defects in T cell development, increased Th1 (show HAND1 Proteins) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.

  3. provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2/VAV1 (show VAV1 Proteins) and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.

  4. GRB2 physically links cyt (show CYGB Proteins)-PTPe (show PTPRE Proteins) with Src (show SRC Proteins) and enables cyt (show CYGB Proteins)-PTPe (show PTPRE Proteins) to activate Src (show SRC Proteins) downstream of activated integrins in osteoclast-like cells.

  5. SUMOylation of Grb2 enhances the ERK (show EPHB2 Proteins) activity by increasing its binding with Sos1 (show SOS1 Proteins).

  6. Data indicate that growth factor receptor (show RYK Proteins) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (show FOXD3 Proteins)), and pregulated Grb2 interacts with huntingtin (Htt (show HTT Proteins)).

  7. Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.

  8. Findings indicate Grb2 as a new FAK (show PTK2 Proteins) activator and in coordinating PTPalpha (show PTPRA Proteins) tyrosine phosphorylation to enable downstream integrin signaling and migration.

  9. Grb2 is not required for the establishment of the glomerular filtration barrier in vivo.

  10. Study shows that the ability of Sos1/Grb2 to appropriately regulate pluripotency and differentiation factors and to initiate primitive endoderm development requires collective binding of multiple Sos1/Grb2 domains to their protein and phospholipid ligands.

Human Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. ACTB (show ACTB Proteins), CDKN1B (show CDKN1B Proteins), GAPDH (show GAPDH Proteins), GRB2, RHOA (show RHOA Proteins) and SDCBP (show SDCBP Proteins) are potent reference genes in neuroendocrine tumors of the lung.

  2. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 Proteins). As well as defining a novel mechanism of Akt (show AKT1 Proteins) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (show FGFR2 Proteins), Plc11 and Grb2 correlate with patient survival

  3. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (show SHC1 Proteins) (Gads (show GRAP2 Proteins)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC Proteins) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 Proteins) with variable affinity

  4. investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation

  5. The study presents EPR (show EREG Proteins) spectroscopic analysis of the binding of the wild-type and mutant Grb2 SH2 domains to the CSpYVNVQC peptide variant. These data confirm that the binding specificity of SH2 domains, even that of Grb2, results from multiple factors and does not depend merely on the nature of one particular residue.

  6. TGF-beta2 (show TGFB2 Proteins) induces Grb2 to recruit PI3-K (show PIK3CA Proteins) to TGF-RII that activates JNK (show MAPK8 Proteins)/AP-1 (show FOSB Proteins)-signaling and augments invasiveness of Theileria-transformed macrophages.

  7. Genetic variation near GRB2 on chromosome 17q25.1 is associated with sight-threatening diabetic retinopathy.

  8. Only monomeric Grb2 is capable of upregulating MAP kinase (show MAPK1 Proteins) signalling. The dimeric state is inhibitory to this process. The self-association/dissociation of Grb2 represents a switch that regulates MAP kinase (show MAPK1 Proteins) activity and hence controls cancer progression.

  9. The immunoglobulin tail tyrosine motif in the cytoplasmic segments of membrane-bound IgGs acts as the principle signal amplifier by incorporating a Grb2-Btk (show BTK Proteins) signaling.

  10. findings show that regions outside of the consensus PxxPxR sites drive the high affinity association of GRB2 with SH3 domain ligands

Pig (Porcine) Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Proteins) stimulation of Shc (show SHC1 Proteins) facilitates the transfer of Grb2 to p85 (show ARHGEF7 Proteins) resulting in enhanced PI3K activation and AKT (show AKT1 Proteins) phosphorylation leading to enhanced cell proliferation and migration

GRB2 Protein Profile

Protein Summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GRB2

  • growth factor receptor-bound protein 2 (GRB2)
  • Growth factor receptor-bound protein 2 (grb2)
  • growth factor receptor-bound protein 2 (grb2)
  • growth factor receptor bound protein 2 (Grb2)
  • growth factor receptor-bound protein 2 (LOC100342500)
  • growth factor receptor-bound protein 2 (Grb2)
  • growth factor receptor-bound protein 2b (grb2b)
  • AA408164 protein
  • ASH protein
  • EGFRBP-GRB2 protein
  • grb2 protein
  • Grb3-3 protein
  • MST084 protein
  • MSTP084 protein
  • NCKAP2 protein
  • wu:fb18e12 protein
  • wu:fb34e06 protein
  • zgc:73077 protein

Protein level used designations for GRB2

growth factor receptor-bound protein 2 , Growth factor receptor-bound protein 2 , SH2/SH3 adapter GRB2 , adapter protein GRB2 , protein Ash , HT027 , abundant SRC homology , epidermal growth factor receptor-binding protein GRB2 , growth factor receptor-bound protein 3 , growth factor receptor bound protein 2 , fb18e12

737245 Pan troglodytes
100306767 Salmo salar
100528114 Ictalurus punctatus
14784 Mus musculus
81504 Rattus norvegicus
2885 Homo sapiens
483312 Canis lupus familiaris
535298 Bos taurus
100342500 Oryctolagus cuniculus
100715453 Cavia porcellus
100192436 Sus scrofa
386572 Gallus gallus
101109893 Ovis aries
100173972 Pongo abelii
406308 Danio rerio
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