GRB2 Products
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Categories
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured GRB2 Categories
GRB2 Antibodies
High quality antibodies with extensive validation data.
GRB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
GRB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GRB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Chicken, Dog, Human, Mouse, Rat
Application
ELISA, IHC (p)
Validations
- (2)
- (1)
Cat. No.
ABIN686932
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Pig, Rat
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN184670
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, ICC
Validations
- (9)
Cat. No.
ABIN2854697
Quantity
100 μL
Datasheet
Datasheet
Recommended GRB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6956336
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967248
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380816
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended GRB2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355702
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355704
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3122684
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GRB2 products
: "Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 27, Issue 2, pp. 120-131, (2017) (PubMed).: "Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer." in: Cancer letters, Vol. 353, Issue 2, pp. 281-9, (2014) (PubMed).
: "Recruitment of the adaptor protein Grb2 to EGFR tetramers." in: Biochemistry, Vol. 53, Issue 16, pp. 2594-604, (2014) (PubMed).
: "An analysis of the phosphoproteome of immune cell lines exposed to the immunomodulatory mycotoxin deoxynivalenol." in: Biochimica et biophysica acta, Vol. 1814, Issue 7, pp. 850-7, (2011) (PubMed).
: "The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts." in: Molecular and cellular biology, Vol. 30, Issue 18, pp. 4492-506, (2010) (PubMed).
: "Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation." in: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1597-608, (2010) (PubMed).
: "Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation." in: The Journal of biological chemistry, Vol. 283, Issue 3, pp. 1428-36, (2008) (PubMed).
: "Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction." in: Cellular signalling, Vol. 19, Issue 11, pp. 2277-85, (2007) (PubMed).
: "Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 46, pp. 18013-8, (2007) (PubMed).
: "Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway." in: American journal of physiology. Cell physiology, Vol. 292, Issue 6, pp. C2185-96, (2007) (PubMed).
Synonyms and alternative names related to GRB2
growth factor receptor bound protein 2 (GRB2), growth factor receptor-bound protein 2 (grb2), growth factor receptor bound protein 2 (Grb2), growth factor receptor-bound protein 2b (grb2b), AA408164, Ash, ASH, EGFRBP-GRB2, GRB2, grb2, Grb3-3, MST084, MSTP084, NCKAP2, wu:fb18e12, wu:fb34e06, zgc:73077Protein level used designations for GRB2
- growth factor receptor-bound protein 2
- Growth factor receptor-bound protein 2
- SH2/SH3 adapter GRB2
- adapter protein GRB2
- protein Ash
- HT027
- abundant SRC homology
- epidermal growth factor receptor-binding protein GRB2
- growth factor receptor-bound protein 3
- growth factor receptor bound protein 2
- fb18e12
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