Browse our HBEGF Proteins (HBEGF)

Full name:
Heparin-Binding EGF-Like Growth Factor Proteins (HBEGF)
On are 29 Heparin-Binding EGF-Like Growth Factor (HBEGF) Proteins from 10 different suppliers available. Additionally we are shipping HBEGF Antibodies (76) and HBEGF Kits (57) and many more products for this protein. A total of 168 HBEGF products are currently listed.
AW047313, Dtr, Dts, DTSF, GFHB, HB-EGF, HBEGF, Hegfl, zgc:165443, zgc:175091
list all proteins Gene Name GeneID UniProt
HBEGF 1839 Q99075
HBEGF 25433 Q06175
HBEGF 15200 Q06186

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HBEGF Proteins (HBEGF) by Origin

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Top referenced HBEGF Proteins

  1. Human HBEGF Protein expressed in Escherichia coli (E. coli) - ABIN2666822 : Jackson, Qiu, Sunnarborg, Chang, Zhang, Patterson, Lee: Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. in The EMBO journal 2003 (PubMed)
    Show all 6 references for 2666822

  2. Human HBEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2002569 : Higashiyama, Abraham, Miller, Fiddes, Klagsbrun: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 4 references for 2002569

More Proteins for HBEGF Interaction Partners

Zebrafish Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. These results suggest that there is an EGF (show EGF Proteins) signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.

Human Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. Results show that HBEGF is highly expressed in primary ovarian tumors and increases as the disease progresses.

  2. Serous carcinomatous component championed by expression of HB-EGF predisposes to recurrence/metastasis in stage I metastasis and recurrence in stage I uterine malignant mixed mullerian tumor.

  3. Annexin A2 (show ANXA2 Proteins) and HB-EGF are overexpressed and are being secreted into serum in Her-2 (show ERBB2 Proteins) negative breast cancer patients.

  4. Study demonstrates that HBEGF is post-transcriptionally regulated by low O2 (placental environment) through a mechanism involving interactions of miRNAs with its 3'UTR.

  5. MMP14 (show MMP14 Proteins) plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF, which accelerates lung tumor progression.

  6. These results indicate that this new anti-HB-EGF mAb 2-108 would be useful in the diagnosis of HB-EGF-related cancers and would be a strong tool in both basic and clinical research on HB-EGF.

  7. This antibody reacts with human HB-EGF but not mouse HB-EGF. No cross-reactivity to other EGFR (show EGFR Proteins) ligands was observed by antigen ELISA.

  8. HB-EGF is a molecular target for the resistance of ovarian cancer to paclitaxel and CRM197 as a HB-EGF-targeted agent might be a chemosensitizing agent for paclitaxel-resistant ovarian carcinoma

  9. Data suggest that placental expression of HBEGF, EGF (show EGF Proteins) (epidermal GF), and TGFA (show TGFA Proteins) (transforming GF alpha) is down-regulated in pre-eclampsia as compared to normal term birth; each growth factor blocks cell death/apoptosis of cytotrophoblast cell line.

  10. Serum sHB (show SHB Proteins)-EGF (show EGF Proteins) is closely correlated with advanced stage gastric cancer and can be a promising serological biomarker for GC.

Mouse (Murine) Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. These results indicate that ATX (show ENPP2 Proteins)-lysophosphatidic acid-LPA3 (show LPAR3 Proteins) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways.

  2. our results suggest that shedding of HB-EGF from endothelium plays an important role in Ang II (show AGT Proteins)-induced renal injury by linking Ang II (show AGT Proteins)-AT1R (show AGTRAP Proteins) with EGFR (show EGFR Proteins) transactivation.

  3. Results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes intestinal myofibroblasts migration through ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins) activation, which, in turn, could support cancer progression.

  4. this study revealed that HB-EGF as well as HGF (show HGF Proteins) inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.

  5. Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice.

  6. Pelvic irradiation increases versican (show Vcan Proteins) expression in bladder and rectum.

  7. Psychiatric, social-behavioral and cognitive abnormalities were also observed in hippocampal Hbegf knockout mice.

  8. HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model

  9. mice in which DTR is expressed on conventional Dendritic cells display marked lymph node hypocellularity and reduced frequency of Dendritic cells in the same organs but not in spleen or nonlymphoid tissues.

  10. miR (show MLXIP Proteins)-96 promotes osteogenic differentiation by inhibiting HB-EGF and by blocking the HB-EGF-EGFR (show EGFR Proteins) signaling pathway in osteoblastic cells

Cow (Bovine) Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.

  2. Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.

HBEGF Protein Profile

Protein Summary

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Alternative names and synonyms associated with HBEGF

  • heparin-binding EGF-like growth factor b (hbegfb)
  • heparin-binding EGF-like growth factor (HBEGF)
  • Heparin-binding EGF-like growth factor (hbegf)
  • heparin-binding EGF-like growth factor a (hbegfa)
  • heparin-binding EGF-like growth factor (LOC100232539)
  • heparin-binding EGF-like growth factor (Hbegf)
  • heparin-binding epidermal growth factor (LOC100008809)
  • AW047313 protein
  • Dtr protein
  • Dts protein
  • DTSF protein
  • GFHB protein
  • HB-EGF protein
  • HBEGF protein
  • Hegfl protein
  • zgc:165443 protein
  • zgc:175091 protein

Protein level used designations for HBEGF

proheparin-binding EGF-like growth factor , heparin-binding EGF-like growth factor , Heparin-binding EGF-like growth factor , diphtheria toxin receptor (heparin-binding EGF-like growth factor) , diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) , heparin-binding epidermal growth factor , Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor) , heparin binding epidermal growth factor-like growth factor , heparin-binding epidermal -growth - like growth factor , heparin-binding epidermal -growth factor , diphtheria toxin receptor , heparin-binding epidermal growth factor-like growth factor

407664 Danio rerio
695559 Macaca mulatta
735979 Pan troglodytes
100305262 Oncorhynchus mykiss
607007 Canis lupus familiaris
797938 Danio rerio
100232539 Taeniopygia guttata
1839 Homo sapiens
25433 Rattus norvegicus
15200 Mus musculus
395654 Gallus gallus
397564 Sus scrofa
522921 Bos taurus
100008809 Oryctolagus cuniculus
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