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Human HBEGF Protein expressed in Escherichia coli (E. coli) - ABIN2666822
Jackson, Qiu, Sunnarborg, Chang, Zhang, Patterson, Lee: Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. in The EMBO journal 2003
Show all 6 references for ABIN2666822
Human HBEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2002569
Higashiyama, Abraham, Miller, Fiddes, Klagsbrun: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. in Science (New York, N.Y.) 1991
Show all 4 references for ABIN2002569
These results suggest that there is an EGF (show EGF Proteins) signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
Study demonstrates that HBEGF is post-transcriptionally regulated by low O2 (placental environment) through a mechanism involving interactions of miRNAs with its 3'UTR.
MMP14 (show MMP14 Proteins) plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF, which accelerates lung tumor progression.
These results indicate that this new anti-HB-EGF mAb 2-108 would be useful in the diagnosis of HB-EGF-related cancers and would be a strong tool in both basic and clinical research on HB-EGF.
This antibody reacts with human HB-EGF but not mouse HB-EGF. No cross-reactivity to other EGFR (show EGFR Proteins) ligands was observed by antigen ELISA.
HB-EGF is a molecular target for the resistance of ovarian cancer to paclitaxel and CRM197 as a HB-EGF-targeted agent might be a chemosensitizing agent for paclitaxel-resistant ovarian carcinoma
Data suggest that placental expression of HBEGF, EGF (show EGF Proteins) (epidermal GF), and TGFA (show TGFA Proteins) (transforming GF alpha) is down-regulated in pre-eclampsia as compared to normal term birth; each growth factor blocks cell death/apoptosis of cytotrophoblast cell line.
Serum sHB (show SHB Proteins)-EGF (show EGF Proteins) is closely correlated with advanced stage gastric cancer and can be a promising serological biomarker for GC.
Studies indicate that heparin-binding EGF-like growth factor (HB-EGF) is a therapeutic target in some types of cancers.
the relative expression of hyalurosome (CD44 (show CD44 Proteins), HAS3 (show HAS3 Proteins), HB-EGF) genes was found to be reduced in patients prior to topical treatment and to be notably increased following treatment.
Urinary levels of NGF (show NGFB Proteins) and HB-EGF may be potential biomarkers for evaluating outcome of overactive bladder syndrome treatment.
Results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes intestinal myofibroblasts migration through ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins) activation, which, in turn, could support cancer progression.
this study revealed that HB-EGF as well as HGF (show HGF Proteins) inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice.
Pelvic irradiation increases versican (show Vcan Proteins) expression in bladder and rectum.
Psychiatric, social-behavioral and cognitive abnormalities were also observed in hippocampal Hbegf knockout mice.
HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model
mice in which DTR is expressed on conventional Dendritic cells display marked lymph node hypocellularity and reduced frequency of Dendritic cells in the same organs but not in spleen or nonlymphoid tissues.
miR (show MLXIP Proteins)-96 promotes osteogenic differentiation by inhibiting HB-EGF and by blocking the HB-EGF-EGFR (show EGFR Proteins) signaling pathway in osteoblastic cells
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
Decreased nitric oxide bioavailability leads to increased HB-EGF expression, which may be an important mediator of the resulting progressive diabetic nephropathy in eNOS (show NOS3 Proteins)-knockout diabetic mice.
These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
proheparin-binding EGF-like growth factor
, heparin-binding EGF-like growth factor
, Heparin-binding EGF-like growth factor
, diphtheria toxin receptor (heparin-binding EGF-like growth factor)
, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
, heparin-binding epidermal growth factor
, Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
, heparin binding epidermal growth factor-like growth factor
, heparin-binding epidermal -growth - like growth factor
, heparin-binding epidermal -growth factor
, diphtheria toxin receptor
, heparin-binding epidermal growth factor-like growth factor