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Browse our HBEGF Proteins (HBEGF)

Full name:
Heparin-Binding EGF-Like Growth Factor Proteins (HBEGF)
On are 29 Heparin-Binding EGF-Like Growth Factor (HBEGF) Proteins from 10 different suppliers available. Additionally we are shipping HBEGF Antibodies (66) and HBEGF Kits (50) and many more products for this protein. A total of 149 HBEGF products are currently listed.
AW047313, Dtr, Dts, DTSF, GFHB, HB-EGF, HBEGF, Hegfl, zgc:165443, zgc:175091
list all proteins Gene Name GeneID UniProt
HBEGF 1839 Q99075
HBEGF 25433 Q06175
HBEGF 15200 Q06186

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HBEGF Proteins (HBEGF) by Origin

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Top referenced HBEGF Proteins

  1. Human HBEGF Protein expressed in Escherichia coli (E. coli) - ABIN2666822 : Jackson, Qiu, Sunnarborg, Chang, Zhang, Patterson, Lee: Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. in The EMBO journal 2003 (PubMed)
    Show all 6 references for ABIN2666822

  2. Human HBEGF Protein expressed in Baculovirus infected Insect Cells - ABIN2002569 : Higashiyama, Abraham, Miller, Fiddes, Klagsbrun: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 4 references for ABIN2002569

More Proteins for HBEGF Interaction Partners

Zebrafish Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. These results suggest that there is an EGF (show EGF Proteins) signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.

Human Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. HB-EGF is a molecular target for the resistance of ovarian cancer to paclitaxel and CRM197 as a HB-EGF-targeted agent might be a chemosensitizing agent for paclitaxel-resistant ovarian carcinoma

  2. Data suggest that placental expression of HBEGF, EGF (show EGF Proteins) (epidermal GF), and TGFA (show TGFA Proteins) (transforming GF alpha) is down-regulated in pre-eclampsia as compared to normal term birth; each growth factor blocks cell death/apoptosis of cytotrophoblast cell line.

  3. Serum sHB (show SHB Proteins)-EGF (show EGF Proteins) is closely correlated with advanced stage gastric cancer and can be a promising serological biomarker for GC.

  4. Studies indicate that heparin-binding EGF-like growth factor (HB-EGF) is a therapeutic target in some types of cancers.

  5. the relative expression of hyalurosome (CD44 (show CD44 Proteins), HAS3 (show HAS3 Proteins), HB-EGF) genes was found to be reduced in patients prior to topical treatment and to be notably increased following treatment.

  6. Urinary levels of NGF (show NGFB Proteins) and HB-EGF may be potential biomarkers for evaluating outcome of overactive bladder syndrome treatment.

  7. HB-EGF is a biomarker for LPA1 (show LPAR1 Proteins) receptor activation in human breast and prostate cancers.

  8. MiR (show MLXIP Proteins)-212 exerts suppressive effect on SKOV3 ovarian cancer cells through targeting HBEGF.

  9. Suggest high levels of HB-EGF contribute to carotid plaque stabilization and reduce the incidence of acute coronary events.

  10. Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo.

Mouse (Murine) Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice.

  2. Pelvic irradiation increases versican (show Vcan Proteins) expression in bladder and rectum.

  3. Psychiatric, social-behavioral and cognitive abnormalities were also observed in hippocampal Hbegf knockout mice.

  4. HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model

  5. mice in which DTR is expressed on conventional Dendritic cells display marked lymph node hypocellularity and reduced frequency of Dendritic cells in the same organs but not in spleen or nonlymphoid tissues.

  6. miR (show MLXIP Proteins)-96 promotes osteogenic differentiation by inhibiting HB-EGF and by blocking the HB-EGF-EGFR (show EGFR Proteins) signaling pathway in osteoblastic cells

  7. Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.

  8. Decreased nitric oxide bioavailability leads to increased HB-EGF expression, which may be an important mediator of the resulting progressive diabetic nephropathy in eNOS (show NOS3 Proteins)-knockout diabetic mice.

  9. HB-EGF changed morphology of 2D and Bioactive3D cultured astrocytes toward a radial glia-like phenotype and induced the expression of intermediate filament and progenitor cell marker protein nestin (show NES Proteins).

  10. HB-EGF induction on Snail (show SNAI1 Proteins) expression is dependent on the EGFR (show EGFR Proteins)-ERK (show EPHB2 Proteins)-Stat3 (show STAT3 Proteins) pathway.

Cow (Bovine) Heparin-Binding EGF-Like Growth Factor (HBEGF) interaction partners

  1. These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.

  2. Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.

HBEGF Protein Profile

Protein Summary

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Alternative names and synonyms associated with HBEGF

  • heparin-binding EGF-like growth factor b (hbegfb)
  • heparin-binding EGF-like growth factor (HBEGF)
  • Heparin-binding EGF-like growth factor (hbegf)
  • heparin-binding EGF-like growth factor a (hbegfa)
  • heparin-binding EGF-like growth factor (LOC100232539)
  • heparin-binding EGF-like growth factor (Hbegf)
  • heparin-binding epidermal growth factor (LOC100008809)
  • AW047313 protein
  • Dtr protein
  • Dts protein
  • DTSF protein
  • GFHB protein
  • HB-EGF protein
  • HBEGF protein
  • Hegfl protein
  • zgc:165443 protein
  • zgc:175091 protein

Protein level used designations for HBEGF

proheparin-binding EGF-like growth factor , heparin-binding EGF-like growth factor , Heparin-binding EGF-like growth factor , diphtheria toxin receptor (heparin-binding EGF-like growth factor) , diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) , heparin-binding epidermal growth factor , Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor) , heparin binding epidermal growth factor-like growth factor , heparin-binding epidermal -growth - like growth factor , heparin-binding epidermal -growth factor , diphtheria toxin receptor , heparin-binding epidermal growth factor-like growth factor

407664 Danio rerio
695559 Macaca mulatta
735979 Pan troglodytes
100305262 Oncorhynchus mykiss
607007 Canis lupus familiaris
797938 Danio rerio
100232539 Taeniopygia guttata
1839 Homo sapiens
25433 Rattus norvegicus
15200 Mus musculus
395654 Gallus gallus
397564 Sus scrofa
522921 Bos taurus
100008809 Oryctolagus cuniculus
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