HBEGF Protein (AA 24-160) (Fc Tag)
Quick Overview for HBEGF Protein (AA 24-160) (Fc Tag) (ABIN7092863)
Target
See all HBEGF ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 24-160
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Purification tag / Conjugate
- This HBEGF protein is labelled with Fc Tag.
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Purpose
- Recombinant mouse HBEGF(24-160) protein with C-terminal human Fc tag
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Specificity
- Mouse HBEGF(Glu24-Thr160) hFc(Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) protein (His-IF2DI Tag)
HBEGF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 20-160) protein (Fc Tag)HBEGF Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (His tag)HBEGF Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) (Active) protein (His tag)HBEGF Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
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Alternative Name
- HBEGF
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Background
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AW047313,Dtr,Dts,Hegfl
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB/Swiss-Prot Function] -
Molecular Weight
- predicted molecular mass of 41.3 kDa after removal of the signal peptide.The apparent molecular mass of mHBEGF(24-160)-hFc is 40-55 kDa due to glycosylation.
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UniProt
- Q06186
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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