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Human IGF1R ELISA Kit for Sandwich ELISA - ABIN417695
Bahhnassy, Mohanad, Shaarawy, Ismail, El-Bastawisy, Ashmawy, Zekri et al.: Transforming growth factor-β, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and ... in Molecular medicine reports 2015
There is an accelerated loss of IGF1R, following loss of UBQLN1 (show UBQLN1 ELISA Kits) in lung adenocarcinoma cells.
data show that the GSK3B (show GSK3b ELISA Kits)-FOXO3 (show FOXO3 ELISA Kits) pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R after partial hepatectomy.
selective impairment of IGF-1 (show IGF1 ELISA Kits)-induced DNA synthesis in lymphocytes of CDG patients through decreased gene expression and hypoglycosylation of the IGF-1 (show IGF1 ELISA Kits) receptor
The INSR (show INSR ELISA Kits) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Our findings suggest a novel mechanism by which CCE procyanidins can promote proteasome-independent degradation of nuclear Nrf2 (show GABPA ELISA Kits) through IGF-1R phosphorylation and cysteine protease (show CTSB ELISA Kits) activation.
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)
These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.
Genetic variants in the IGF1 (show IGF1 ELISA Kits) and IGF1R genes might not be associated with high myopia in Han Chinese. Further studies are needed to verify the possible function of IGF1 (show IGF1 ELISA Kits) and IGF1R in the development of myopia.
Small interfering RNA-mediated IGF-1R knockdown mimics the effects of miR (show MLXIP ELISA Kits)-375 up-regulation, while overexpression of Insulin Like Growth Factor 1 Receptor partially reverses those effects in oral squamous cell carcinoma cells.
miR (show MLXIP ELISA Kits)-30a suppressed migration and invasion through the IGF1R/p-AKT (show AKT1 ELISA Kits)/b-catenin/E-cadherin (show CDH1 ELISA Kits) pathway in colorectal cancer cells.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (show PAPPA ELISA Kits) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB ELISA Kits)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA ELISA Kits) secretion as a modulator of IGF1 (show IGF1 ELISA Kits) in cattle with COD (show SNRPB ELISA Kits)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (show INS ELISA Kits)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain (show CAPN2 ELISA Kits)/HhaI, and UCP-3 (show UCP3 ELISA Kits)/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 ELISA Kits), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 ELISA Kits) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (show IGF1 ELISA Kits) down-regulated functional IGF-I receptor via GSK-3beta (show GSK3b ELISA Kits) inhibition and mTOR (show FRAP1 ELISA Kits) activation; constitutive activity of GSK-3beta (show GSK3b ELISA Kits) maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (show IGF1 ELISA Kits) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (show IGF1 ELISA Kits), IGF-II, and IGFBP-3 (show IGFBP3 ELISA Kits) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (show IL1B ELISA Kits) impaired the actions of IGF-I (show IGF1 ELISA Kits) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (show SST ELISA Kits)-containing islet D-cells
This study suggests an association between the affinity of insulin (show INS ELISA Kits) receptors and number of IGF-1 (show IGF1 ELISA Kits) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
Data show that tumors lacking PSMA (show FOLH1 ELISA Kits) had less than half the abundance of type 1 insulin (show INS ELISA Kits)-like growth factor receptor (show RYK ELISA Kits) (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT (show AKT1 ELISA Kits) signaling, and more activity in the proliferative pathway mediated by MAPK (show MAPK1 ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits) signaling.
let-7g regulates autophagy in mouse granulosa cells by targeting insulin-like growth factor 1 receptor and downregulating protein kinase B (show AKT1 ELISA Kits)/mammalian target of rapamycin (show FRAP1 ELISA Kits) signaling
VEGF (show VEGFA ELISA Kits) and IGF1 (show IGF1 ELISA Kits) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (show MDK ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling was involved in the role of VEGF (show VEGFA ELISA Kits) and IGF1 (show IGF1 ELISA Kits).
miR (show MLXIP ELISA Kits)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
Data (including data from studies using heterozygous transgenic mice) suggest that gene expression in liver is altered in a model of inflammation of liver due to partial deficiency of Igf1 (show IGF1 ELISA Kits); this leads to over-expression of Igf1 (show IGF1 ELISA Kits) receptor, inflammation mediators, and acute-phase proteins, but under-expression of cytoskeletal proteins, extracellular matrix proteins, and tight junction proteins.
Findings indicate that the energy-sensing LKB1 (show STK11 ELISA Kits)-AMPK (show PRKAA1 ELISA Kits) pathway regulates IGF1 (show IGF1 ELISA Kits) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R-PKB (show AKT2 ELISA Kits) pathway.
IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.
Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (show INS ELISA Kits) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.
the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 ELISA Kits)-regulated, autophagy-mediated protein degradation
This study evaluated the expression of IGF-1 (show IGF1 ELISA Kits) receptor, insulin receptor (show INSR ELISA Kits) AND IGF-1 (show IGF1 ELISA Kits) in the lammelar tissue of horses with insulin (show INS ELISA Kits)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (show INSR ELISA Kits) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (show IGF1 ELISA Kits)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit