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Human IGF1R ELISA Kit for Sandwich ELISA - ABIN417695
Bahhnassy, Mohanad, Shaarawy, Ismail, El-Bastawisy, Ashmawy, Zekri et al.: Transforming growth factor-β, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and ... in Molecular medicine reports 2015
Our results indicated that miR (show MLXIP ELISA Kits)-100 could exert tumor suppression function by inhibiting PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and MAPK/ERK (show MAPK1 ELISA Kits) signaling pathways via targeting IGFIR
miR (show MLXIP ELISA Kits)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
Results provide a mechanistic understanding for the observation that loss of IGF-1R expression decreases tamoxifen sensitivity resulting from reduced FoxO1 (show FOXO1 ELISA Kits) expression in breast cancer cells.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
Results provide evidence that uPA (show PRAP1 ELISA Kits) and IGF1R directly interact with uPAR (show PLAUR ELISA Kits) enhancing malignant potential of triple-negative breast cancer.
High IGF1R expression is associated with skin melanoma.
This study explores the prognostic effect of MET, MET gene copy number, polysomy of chromosome 7, IGF1R gene copy number and IGF-1 (show IGF1 ELISA Kits) expression in tumor epithelial cells of primary non-small-cell lung cancer in 326 patients.
Low IGF1R expression is associated with low bone mineral density in patients with type 1 diabetes.
Results provide evidence that cathepsin G (show CTSG ELISA Kits) (GC) activates IGF-1R by stimulating IGF-1 (show IGF1 ELISA Kits) release from MCF-7 cells, and that IGF-1R activation is required for CG-induced cell aggregation.
GRK2 (show ADRBK1 ELISA Kits) is negatively related to IGF1R and IGF1R, but not GRK2 (show ADRBK1 ELISA Kits), was associated with the tumour-node-metastasis stage and overall and disease-free survival in hepatocellular carcinoma.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (show PAPPA ELISA Kits) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB ELISA Kits)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA ELISA Kits) secretion as a modulator of IGF1 (show IGF1 ELISA Kits) in cattle with COD (show SNRPB ELISA Kits)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (show INS ELISA Kits)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain (show CAPN2 ELISA Kits)/HhaI, and UCP-3 (show UCP3 ELISA Kits)/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 ELISA Kits), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 ELISA Kits) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (show IGF1 ELISA Kits) down-regulated functional IGF-I receptor via GSK-3beta (show GSK3b ELISA Kits) inhibition and mTOR (show FRAP1 ELISA Kits) activation; constitutive activity of GSK-3beta (show GSK3b ELISA Kits) maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (show IGF1 ELISA Kits) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (show IGF1 ELISA Kits), IGF-II, and IGFBP-3 (show IGFBP3 ELISA Kits) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (show IL1B ELISA Kits) impaired the actions of IGF-I (show IGF1 ELISA Kits) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (show SST ELISA Kits)-containing islet D-cells
This study suggests an association between the affinity of insulin (show INS ELISA Kits) receptors and number of IGF-1 (show IGF1 ELISA Kits) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
Data (including data from studies using heterozygous transgenic mice) suggest that gene expression in liver is altered in a model of inflammation of liver due to partial deficiency of Igf1 (show IGF1 ELISA Kits); this leads to over-expression of Igf1 (show IGF1 ELISA Kits) receptor, inflammation mediators, and acute-phase proteins, but under-expression of cytoskeletal proteins, extracellular matrix proteins, and tight junction proteins.
Findings indicate that the energy-sensing LKB1 (show STK11 ELISA Kits)-AMPK (show PRKAA1 ELISA Kits) pathway regulates IGF1 (show IGF1 ELISA Kits) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R-PKB (show AKT2 ELISA Kits) pathway.
IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.
Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (show INS ELISA Kits) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.
the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 ELISA Kits)-regulated, autophagy-mediated protein degradation
SUMOylation of IGF1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators to increase cell cycle progression and proliferation.
findings demonstrated that significant resistance of the brain to amyloid-beta can be achieved lifelong by suppressing neuronal IGF1R.
Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB ELISA Kits) inhibition required the expression and activation of the insulin receptor (IR (show INSR ELISA Kits))/insulin (show INS ELISA Kits) growth-like factor receptor (IGF1R) for tumor cell proliferation and survival.
Conditional deletion of synaptotagmin-10, the Ca(2 (show CA2 ELISA Kits)+) sensor for IGF1 (show IGF1 ELISA Kits) secretion from mitral cells, or deletion of IGF1 (show IGF1 ELISA Kits) receptor in the olfactory bulb prevented the socially relevant GABAergic long-term potentiation and impaired memory formation after social transmission of food preference.
This study evaluated the expression of IGF-1 (show IGF1 ELISA Kits) receptor, insulin receptor (show INSR ELISA Kits) AND IGF-1 (show IGF1 ELISA Kits) in the lammelar tissue of horses with insulin (show INS ELISA Kits)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (show INSR ELISA Kits) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (show IGF1 ELISA Kits)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit