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Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin (show ADIPOQ ELISA Kits)-mediated signaling pathways.
IGF1R is a direct target of miR (show MLXIP ELISA Kits)-494 in epithelial ovarian carcinoma cells. miR (show MLXIP ELISA Kits)-494 overexpression inhibited IGF1R expression and its downstream signal protein (show KLK7 ELISA Kits) expression. IGF1R downregulation has similar effects to miR (show MLXIP ELISA Kits)-494 overexpression on EOC cells, and overexpression of IGF1R effectively rescued the inhibition of overexpressed miR (show MLXIP ELISA Kits)-494 in EOC cells. miR (show MLXIP ELISA Kits)-494 directly binds the IGF1R 3'-UTR (show UTS2R ELISA Kits).
identification of IGF-1R in odontogenic myxoma is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors
NANOG (show NANOG ELISA Kits) was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 ELISA Kits) phosphorylation in colorectal cancer (CRC (show CALR ELISA Kits)). This coincides with that IGF receptor IGF-1R is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 ELISA Kits)/NANOG (show NANOG ELISA Kits)/Slug (show SNAI2 ELISA Kits) signaling axis in the progression of CRC (show CALR ELISA Kits)
This study suggests IGF1R as a potential biomarker of improved clinical outcome in HR+ve breast cancer patients treated with exemestane. Adding metformin to exemestane treatment may add to this effect
We present multiplexed RO assays for an IGF1R-EGFR (show EGFR ELISA Kits) bispecific antibody (Bs-Ab) and a CTLA4 (show CTLA4 ELISA Kits)-Ig recombinant fusion protein to demonstrate key considerations for accurate RO assessment.
IGF1 (show IGF1 ELISA Kits) pro-forms can induce breast cancer cell proliferation via the IGF1R, independent from the mature IGF1 (show IGF1 ELISA Kits) form.
p53 (show TP53 ELISA Kits) R273H mutation unleashes the inhibition effect of miR (show MLXIP ELISA Kits)-30a on IGF-1R expression, thus leading to elevated activation of IGF-1R-AKT (show AKT1 ELISA Kits) signaling cascade in tumor cells.
miR (show MLXIP ELISA Kits)-214 significantly blocked IGF-1R-forced renal cancer cell proliferation, which was reversed by expression of 3'UTR (show UTS2R ELISA Kits)-less IGF-1R and constitutively active mTORC1.
The findings suggest that miR (show MLXIP ELISA Kits)-98 inhibits cancer cell growth and metastasis by direct targeting IGF1R, implicating miR (show MLXIP ELISA Kits)-98 as a novel potential therapeutic target for oral squamous cell carcinoma (OSCC).
Macrophage IGF1R signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 ELISA Kits) exerts antiatherogenic effects in ApoE (show APOE ELISA Kits) knockout mice.
study recognized the promotion of miR (show MLXIP ELISA Kits)-223 level by AGE-BSA treatment in osteoblast-like MC3T3-E1 cells. The promoted miR (show MLXIP ELISA Kits)-223 targeted IGF-1R and mediated the AGE-BSA-induced apoptosis in MC3T3-E1 cells.
osterix (show SP7 ELISA Kits) is a downstream target of IGF1R in chondrocytes.
NF-kappaB (show NFKB1 ELISA Kits)-miR (show MLXIP ELISA Kits)-195/497-Igf1r/Insr (show INSR ELISA Kits)-Ccnd2 (show CCND2 ELISA Kits)/Ccne1 (show CCNE1 ELISA Kits) plays important roles in myogenesis.
this study, we have characterized epigenetic changes following pregnancy and found that Igf1r and other IGF family members are hypermethylated and downregulated.
IGF1R signaling was necessary for DC-mediated T-ALL survival.
mitochondria, activated by IGF-1R signaling, constitute a critical regulator of information processing in hippocampal neurons.
IGF1R is involved in osteoblast differentiation during fracture repair and it plays an important role in coordinating chondrocyte, osteoclast, and endothelial responses that contribute to endochondral bone formation required for normal fracture repair
ectopic down-regulation of IGF1R reversed the protective effect of miR (show MLXIP ELISA Kits)-100 down-regulation on H2O2-induced apoptosis, revealing that miR (show MLXIP ELISA Kits)-100 regulates cardiomyocyte apoptosis through the association of IGF1R.
Data (including data from studies in knockout mice) suggest that Igf1r plays role in cardiomyocytes during ventricular remodeling of aging; deletion of Igf1r in cardiomyocytes attenuates cardiac aging in male mice.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
insulin-like growth factor I receptor
, IGF-I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor 1 receptor
, line 186