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IGF1R overexpression lead to an increase of cell survival and suppressed cell apoptosis, IGF1R silencing mediated by RNAi abrogate this response of NCI-H446 cells.
mTORC2 (show CRTC2 ELISA Kits) promotes rapamycin- and ligand-induced type I insulin (show INS ELISA Kits)-like growth factor receptor (show RYK ELISA Kits) / insulin receptor (show INSR ELISA Kits) phosphorylation.
The results suggest that severe intra-uterine growth differences (birth weight discordance >20%) are associated with methylation changes in the IGF1R gene in adulthood, independent of genetic effects
Our study demonstrates that the IGF1R/p110b/AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) axis confers resistance to BYL719 in PIK3CA (show PIK3CA ELISA Kits) mutant breast cancers.
we found a SNP (rs2016347) in IGF1R as a potential predictive marker for chemotherapy efficacy in breast cancer patients treated with TAC (show IL2RA ELISA Kits)
HRD1 (show SYVN1 ELISA Kits) interacted with IGF-1R and promoted its ubiquitination and degradation by the proteasome
High expression of IGF1R is associated with breast cancer.
Anoikis resistance of oestrogen-responsive breast cancer cells depends upon IGF activation of the type I IGF receptor and PI3-kinase (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway.
Data suggest that temozolomide (TMZ) resistance associates with insulin like growth factor 1 (show IGF1 ELISA Kits) (IGF-1R) activation, and that simultaneous or prior IGF-1R inhibitors (IGF-1Ri) caused less effective chemo-sensitization.
remarkable therapeutic window observed for BI 885578 is achieved by virtue of the distinctive pharmacokinetic properties of the compound capitalizing on the physiologic mechanism of glucose homeostasis and differential levels of IGF1R and INSR (show INSR ELISA Kits) expression
osterix (show SP7 ELISA Kits) is a downstream target of IGF1R in chondrocytes.
NF-kappaB (show NFKB1 ELISA Kits)-miR (show MLXIP ELISA Kits)-195/497-Igf1r/Insr (show INSR ELISA Kits)-Ccnd2 (show CCND2 ELISA Kits)/Ccne1 (show CCNE1 ELISA Kits) plays important roles in myogenesis.
this study, we have characterized epigenetic changes following pregnancy and found that Igf1r and other IGF family members are hypermethylated and downregulated.
IGF1R signaling was necessary for DC-mediated T-ALL survival.
mitochondria, activated by IGF-1R signaling, constitute a critical regulator of information processing in hippocampal neurons.
IGF1R is involved in osteoblast differentiation during fracture repair and it plays an important role in coordinating chondrocyte, osteoclast, and endothelial responses that contribute to endochondral bone formation required for normal fracture repair
ectopic down-regulation of IGF1R reversed the protective effect of miR (show MLXIP ELISA Kits)-100 down-regulation on H2O2-induced apoptosis, revealing that miR (show MLXIP ELISA Kits)-100 regulates cardiomyocyte apoptosis through the association of IGF1R.
Data (including data from studies in knockout mice) suggest that Igf1r plays role in cardiomyocytes during ventricular remodeling of aging; deletion of Igf1r in cardiomyocytes attenuates cardiac aging in male mice.
The IGF1R ectodomain maintains an autoinhibited state in which the transmembrane domains are held apart.
Data (including data from studies in knockout mice) suggest that, in aging and metabolic stress such as insulin (show INS ELISA Kits) resistance/pregnancy, pancreatic beta-cells exhibit sex differences in Igf2/Igf1r signaling during beta-cell expansion/mass adaptation.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
insulin-like growth factor I receptor
, IGF-I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor 1 receptor
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