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Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA (show APTX Proteins) indicated that expression profiles of PLCzeta (show PLCz1 Proteins), PAWP (show WBP2NL Proteins), and TR-KIT were low in globozoospermic individuals
Different types of cancers harbor mutations in the oncogene (show RAB1A Proteins) KIT
KIT knockdown increased RAS/MAPK (show MAPK1 Proteins) pathway activation in a BRAF (show BRAF Proteins)(V600E)-mutant melanoma cell line.
Multivariate analysis showed that KIT-AL and TET2 mutations were associated with inferior LFS, whereas age 40 years and marrow blast 70% were associated with inferior OS.
the critical physiological role of the KIT-ET3 (show EDN3 Proteins)-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported.
determined that miR (show MLXIP Proteins)-137 can participate in the leukemogenesis by regulating c-kit, which could be used as a therapeutic target for acute myeloid leukemia (show BCL11A Proteins)
Report up-regulation of the mTOR, PDGF, VEGF, and c-kit pathways in a large cohort of Kaposi sarcoma samples.
c-KIT overexpressing cells showed a regression of typical morphological features of malignancy. Taken together these results suggest that c-KIT could be involved in the differentiation of thyroid cells and in tumor progression
low level of MITF (show MITF Proteins) cooperates with oncogenic KIT to transform melanocytes. Activation of the cAMP pathway in transformed (L576P)KIT melanocytes stimulated MITF (show MITF Proteins) expression, and reduced cellular proliferation and sphere formation. These findings highlight the essential role of MITF (show MITF Proteins) in revealing the oncogenic activity of KIT in melanocytes and suggest that the cAMP pathway is a therapeutic target in KIT-mutated melanoma.
These results suggest that CD44 (show CD44 Proteins)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 (show CTLA4 Proteins) pathway.
we studied the efficacy of ACK2, an antibody that blocks KIT, followed by low-dose irradiation as a preconditioning regimen for hematopoietic cell transplantation using a murine model of Mucopolysaccharidosis type II.
C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (show NOX1 Proteins) and catalase (show CAT Proteins), but less of lactoperoxidase (show LPO Proteins) than in matured mononuclear cells.
c-KIT signaling regulates self-renewal capacity and prevents neurodifferentiation in culture.
These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1 (show IL1A Proteins)-driven systemic inflammatory disease.
WNT (show WNT2 Proteins) signaling at an early stage (E12 (show ELSPBP1 Proteins)-E15) of submandibular salivary gland (SMG (show SNRPG Proteins)) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression.
c-kit can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness
Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 (show FOXO3 Proteins) protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.
sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model.
These findings indicate the SCF (show KITLG Proteins)/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.
FGF7 (show FGF7 Proteins) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (show KITLG Proteins) signaling pathway.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
mast/stem cell growth factor receptor Kit
, p145 c-kit
, piebald trait protein
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, soluble KIT variant 1
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
, Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, spotted sterile male
, c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, c-kit receptor
, mast cell growth factor receptor
, c-KIT gene1
, receptor tyrosine kinase c-kit
, Mast/stem cell growth factor receptor
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein