Browse our KIT Proteins (KIT)

Full name:
Mast/stem Cell Growth Factor Receptor Proteins (KIT)
On www.antibodies-online.com are 39 Mast/stem Cell Growth Factor Receptor (KIT) Proteins from 10 different suppliers available. Additionally we are shipping KIT Antibodies (1237) and KIT Kits (42) and many more products for this protein. A total of 1326 KIT products are currently listed.
Synonyms:
Bs, c-kit, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, MGF, PBT, SCFR, SCO1, SCO5, SOW3, Ssm, Tr-kit, W
list all proteins Gene Name GeneID UniProt
KIT 16590 P05532
KIT 3815 P10721
KIT    

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KIT Proteins (KIT) by Origin

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More Proteins for KIT Interaction Partners

Mouse (Murine) Mast/stem Cell Growth Factor Receptor (KIT) interaction partners

  1. C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (show NOX1 Proteins) and catalase (show CAT Proteins), but less of lactoperoxidase (show LPO Proteins) than in matured mononuclear cells.

  2. c-KIT signaling regulates self-renewal capacity and prevents neurodifferentiation in culture.

  3. These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1 (show IL1A Proteins)-driven systemic inflammatory disease.

  4. WNT (show WNT2 Proteins) signaling at an early stage (E12 (show ELSPBP1 Proteins)-E15) of submandibular salivary gland (SMG (show SNRPG Proteins)) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression.

  5. c-kit can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness

  6. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 (show FOXO3 Proteins) protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.

  7. sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model.

  8. These findings indicate the SCF (show KITLG Proteins)/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.

  9. we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival.

  10. IMC-G4 cells had an additional novel c-kit gene mutation of KIT-Tyr421Cys which is considered to induce neoplastic transformation of mouse mast cells

Human Mast/stem Cell Growth Factor Receptor (KIT) interaction partners

  1. Report up-regulation of the mTOR, PDGF, VEGF, and c-kit pathways in a large cohort of Kaposi sarcoma samples.

  2. c-KIT overexpressing cells showed a regression of typical morphological features of malignancy. Taken together these results suggest that c-KIT could be involved in the differentiation of thyroid cells and in tumor progression

  3. low level of MITF (show MITF Proteins) cooperates with oncogenic KIT to transform melanocytes. Activation of the cAMP pathway in transformed (L576P)KIT melanocytes stimulated MITF (show MITF Proteins) expression, and reduced cellular proliferation and sphere formation. These findings highlight the essential role of MITF (show MITF Proteins) in revealing the oncogenic activity of KIT in melanocytes and suggest that the cAMP pathway is a therapeutic target in KIT-mutated melanoma.

  4. This previously unexplored G4-G4 interaction modulates both the conformation and the stability of the overall arrangement of the c-KIT promoter. It is not supported by stacking of single nucleotides but refers to a G4-G4 interaction surface surrounded by a two-nucleotides loop that might represent a reliable unprecedented target for anticancer therapy.

  5. Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells has been reported.

  6. It was found that the absence of mutations in the SRSF2 (show SRSF2 Proteins), ASXL1 (show ASXL1 Proteins), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  7. Point mutation in c-kit gene is associated with sequential development of an ovarian mixed germ cell tumor and systemic mastocytosis with chronic myelomonocytic leukemia.

  8. This study assesses MYB (show MYB Proteins), CD117 and SOX-10 (show SOX10 Proteins) expression in cutaneous adnexal tumors.

  9. EGFR expression was observed in 58% and c-KIT expression was seen in 30% of the cases [triple negative breast cancer]

  10. Canonical TGF-beta (show TGFB1 Proteins) and c-KIT signaling forms a positive, tumor-promoting feedback loop. Disruption of this loop restores TGF-beta (show TGFB1 Proteins) tumor suppressor function and provides the rationale for targeting the TGF-beta (show TGFB1 Proteins)/SCF (show KITLG Proteins) axis as a novel therapeutic strategy for Hepatocellular carcinoma.

Pig (Porcine) Mast/stem Cell Growth Factor Receptor (KIT) interaction partners

  1. mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.

  2. Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.

  3. Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.

Cow (Bovine) Mast/stem Cell Growth Factor Receptor (KIT) interaction partners

  1. FGF7 (show FGF7 Proteins) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (show KITLG Proteins) signaling pathway.

KIT Protein Profile

Protein Summary

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with KIT

  • kit oncogene (Kit)
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT)
  • Bs protein
  • c-kit protein
  • CD117 protein
  • Fdc protein
  • Gsfsco1 protein
  • Gsfsco5 protein
  • Gsfsow3 protein
  • MGF protein
  • PBT protein
  • SCFR protein
  • SCO1 protein
  • SCO5 protein
  • SOW3 protein
  • Ssm protein
  • Tr-kit protein
  • W protein

Protein level used designations for KIT

Dominant white spotting , SCFR , Steel Factor Receptor , belly-spot , c-kit proto-oncogene protein , dominant spotting , mast/stem cell growth factor receptor Kit , proto-oncogene c-Kit , proto-oncogene tyrosine-protein kinase Kit , spotted sterile male , tyrosine-protein kinase Kit , p145 c-kit , piebald trait protein , soluble KIT variant 1 , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein , c-kit , c-KIT gene1 , receptor tyrosine kinase c-kit , c-kit receptor , mast cell growth factor receptor

GENE ID SPECIES
16590 Mus musculus
3815 Homo sapiens
378783 Gallus gallus
403811 Canis lupus familiaris
396810 Sus scrofa
280832 Bos taurus
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