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Browse our MET Proteins (MET)

Full name:
Met Proto-Oncogene Proteins (MET)
On are 52 Met Proto-Oncogene (MET) Proteins from 13 different suppliers available. Additionally we are shipping MET Antibodies (694) and MET Kits (61) and many more products for this protein. A total of 833 MET products are currently listed.
AI838057, AUTS9, c-met, HGF, Hgfr, Par4, RCCP2
list all proteins Gene Name GeneID UniProt
MET 4233 P08581
MET 17295  
MET 24553 P97523

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MET Proteins (MET) by Origin

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Top referenced MET Proteins

  1. Human MET Protein expressed in Human Cells - ABIN2003239 : Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 6 references for ABIN2003239

  2. Cynomolgus MET Protein expressed in Human Cells - ABIN2010130 : Weidner, Di Cesare, Sachs, Brinkmann, Behrens, Birchmeier: Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. in Nature 1996 (PubMed)
    Show all 6 references for ABIN2010130

  3. Human MET Protein expressed in Baculovirus infected Insect Cells - ABIN2003243 : Stephenson, Tronick, Aaronson: Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus. in Cell 1975 (PubMed)
    Show all 6 references for ABIN2003243

  4. Dog (Canine) MET Protein expressed in Human Cells - ABIN2008841 : Birchmeier, Birchmeier, Gherardi, Vande Woude: Met, metastasis, motility and more. in Nature reviews. Molecular cell biology 2003 (PubMed)
    Show all 6 references for ABIN2008841

  5. Rat (Rattus) MET Protein expressed in Human Cells - ABIN2009011 : Pennacchietti, Michieli, Galluzzo, Mazzone, Giordano, Comoglio: Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. in Cancer cell 2003 (PubMed)
    Show all 6 references for ABIN2009011

  6. Mouse (Murine) MET Protein expressed in Human Cells - ABIN2008062 : Boccaccio, Comoglio: Invasive growth: a MET-driven genetic programme for cancer and stem cells. in Nature reviews. Cancer 2006 (PubMed)
    Show all 6 references for ABIN2008062

  7. Human MET Protein expressed in HEK-293 Cells - ABIN2180662 : Rubin, Chan, Bottaro, Burgess, Taylor, Cech, Hirschfield, Wong, Miki, Finch: A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)

More Proteins for MET Interaction Partners

Human Met Proto-Oncogene (MET) interaction partners

  1. Transfection of miR (show MLXIP Proteins)-182 into retinal pigment epithelial (RPE (show RPE Proteins)) cells induced c-Met downregulation, which led to reduced cell proliferation and migration through declines in p-Akt (show AKT1 Proteins) formation. MiR (show MLXIP Proteins)-182 downregulation along with c-Met upregulation in proliferative vitreoretinopathy (PVR (show PVR Proteins)) tissues suggest that these two opposing effects play important roles in PVR (show PVR Proteins) development.

  2. Either upregulating miR (show MLXIP Proteins)-182 in retinal pigment epithelial cells or downregulating c-Met expression reduced HGF/SF (show HGF Proteins)-induced rises in both retinal pigment epithelial cells proliferation and chemotaxis through declines in Akt (show AKT1 Proteins) activation.

  3. his review will describe the mechanisms of aberrant c-Met signaling in colorectal cancer and discuss on additional roles for c-Met receptor through crosstalk with other tyrosine kinase (show TXK Proteins) receptors and cell surface proteins in colorectal cancer

  4. This article reviews aberrations in epidermal growth factor receptor (show EGFR Proteins), MET, and ERBB2 (show ERBB2 Proteins), their therapeutic implications, and future directions in targeting these pathways.

  5. This review highlights treatment options, including clinical trials for ROS1 rearrangement, RET fusions, NTRK1 fusions, MET exon skipping, BRAF mutations, and KRAS mutations.

  6. MET amplification and overexpression, assessed by multiple methods, were associated with a worse prognosis in univariate analyses. However, only MET amplification by FISH and Met expression by SRM (show SRM Proteins) were independent prognostic biomarkers.

  7. AZD9291 is the first and only FDA approved third-generation epidermal growth factor receptor (EGFR (show EGFR Proteins)) tyrosine kinase (show TXK Proteins) inhibitors for T790M-positive advanced non-small cell patients. The resistance to AZD9291 arises after therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR (show EGFR Proteins) C797S mutation, EGFR (show EGFR Proteins) L718Q mutation, and amplifications of HER-2 (show ERBB2 Proteins), MET, or ERBB2 (show ERBB2 Proteins). [review]

  8. study indicates that tyrosine kinase (show TXK Proteins) signaling in host pre-osteoclasts/osteoclasts is critical for bone destruction induced by tumor cells and that targeting of MET/VEGF receptor (show FLT1 Proteins)/FMS (show CSF1R Proteins) activity makes it a promising therapeutic candidate for the treatment of prostate cancer patients with bone metastasis.

  9. Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (show POLD3 Proteins) protein isoform of Shc (show SHC1 Proteins) and its effects on rewiring binding effector complexes according to the activation state of the receptor.

  10. Specifically, miR (show MLXIP Proteins)-130a was attenuated in HFD-induced PCa (show FLVCR1 Proteins) progression with MET overexpression. miRNAs thus have implications in the mechanism, prevention and treatment of HFD-induced prostate cancer (PCa (show FLVCR1 Proteins))progression.

Mouse (Murine) Met Proto-Oncogene (MET) interaction partners

  1. We found the roles of hepatocyte growth factor (HGF (show HGF Proteins)) signaling in stria vascularis development for the first time and that lack of HGF (show HGF Proteins) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (show HGF Proteins) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva

  2. c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.

  3. In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS (show RALGDS Proteins) at Y752 in its RBD (show CACNA1D Proteins), which blocks the binding of Ras to RalGDS (show RALGDS Proteins).

  4. study demonstrates that co-activation of AKT (show AKT1 Proteins) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN (show FASN Proteins) pathway.

  5. Molecular and functional studies revealed that ectopic Met expression in limb mesenchyme does not alter HGF (show HGF Proteins) expression patterns and levels, but impairs HGF (show HGF Proteins) bioavailability

  6. miR-206 suppressed c-Met expression in gastric cancer and could function as a potent tumor suppressor in c-Met overexpressing tumors.

  7. Meg3 overexpression in insulinoma cells down-regulated the expression of the protooncogene c-met.

  8. our results support the concept of the acrosome as a lysosome-related organelle and provide evidence for the identification of MET as a tyrosine kinase receptor (show KDR Proteins) that may play a role in fertilization.

  9. We show that a subset of adult calcitonin gene-related peptide (CGRP (show CALCA Proteins))-expressing myenteric neurons produce MET, the receptor for hepatocyte growth factor (show HGF Proteins).

  10. HGF and c-met inhibition by means of a novel monoclonal neutralizing antibody inhibits tumor growth in prostate cancer cells and in mouse xenografts.

Cow (Bovine) Met Proto-Oncogene (MET) interaction partners

  1. possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

MET Protein Profile

Protein Summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MET

  • met proto-oncogene (MET)
  • met proto-oncogene (Met)
  • met proto-oncogene (hepatocyte growth factor receptor) (MET)
  • AI838057 protein
  • AUTS9 protein
  • c-met protein
  • HGF protein
  • Hgfr protein
  • Par4 protein
  • RCCP2 protein

Protein level used designations for Met Proto-Oncogene Proteins (MET)

HGF receptor , HGF/SF receptor , SF receptor , hepatocyte growth factor receptor , met proto-oncogene tyrosine kinase , proto-oncogene c-Met , scatter factor receptor , tyrosine-protein kinase Met , c-Met , HGF receptor c-Met

4233 Homo sapiens
17295 Mus musculus
24553 Rattus norvegicus
403438 Canis lupus familiaris
280855 Bos taurus
654328 Sus scrofa
100126565 Oryctolagus cuniculus
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