Browse our MET Proteins (MET)

Full name:
Met Proto-Oncogene Proteins (MET)
On are 66 Met Proto-Oncogene (MET) Proteins from 13 different suppliers available. Additionally we are shipping MET Antibodies (709) and MET Kits (65) and many more products for this protein. A total of 866 MET products are currently listed.
AI838057, AUTS9, c-met, HGF, Hgfr, Par4, RCCP2
list all proteins Gene Name GeneID UniProt
MET 4233 P08581
MET 17295  
MET 24553 P97523

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MET Proteins (MET) by Origin

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Top referenced MET Proteins

  1. Human MET Protein expressed in Human Cells - ABIN2003239 : Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 6 references for 2003239

  2. Cynomolgus MET Protein expressed in Human Cells - ABIN2010132 : Weidner, Di Cesare, Sachs, Brinkmann, Behrens, Birchmeier: Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. in Nature 1996 (PubMed)
    Show all 6 references for 2010132

  3. Human MET Protein expressed in Baculovirus infected Insect Cells - ABIN2003243 : Stephenson, Tronick, Aaronson: Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus. in Cell 1975 (PubMed)
    Show all 6 references for 2003243

  4. Dog (Canine) MET Protein expressed in Human Cells - ABIN2008841 : Birchmeier, Birchmeier, Gherardi, Vande Woude: Met, metastasis, motility and more. in Nature reviews. Molecular cell biology 2003 (PubMed)
    Show all 6 references for 2008841

  5. Rat (Rattus) MET Protein expressed in Human Cells - ABIN2009011 : Pennacchietti, Michieli, Galluzzo, Mazzone, Giordano, Comoglio: Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. in Cancer cell 2003 (PubMed)
    Show all 6 references for 2009011

  6. Mouse (Murine) MET Protein expressed in Human Cells - ABIN2008062 : Boccaccio, Comoglio: Invasive growth: a MET-driven genetic programme for cancer and stem cells. in Nature reviews. Cancer 2006 (PubMed)
    Show all 6 references for 2008062

  7. Human MET Protein expressed in HEK-293 Cells - ABIN2180660 : Rubin, Chan, Bottaro, Burgess, Taylor, Cech, Hirschfield, Wong, Miki, Finch: A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)

More Proteins for MET Interaction Partners

Human Met Proto-Oncogene (MET) interaction partners

  1. NCTD suppressed not only the expression of the total EGFR and the phosphorylated EGFR but also the expression of the total c-Met.

  2. Altered Met receptor phosphorylation and LRP1 (show LRP1 Proteins)-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting

  3. Dual MET and SMO Inhibitors are potent antiproliferative agents in EGFR (show EGFR Proteins)-Tyrosine kinase (show TXK Proteins) inhibitors resistant human non small cell lung cancer.

  4. although the juxtamembrane mutations of MET do not affect its known proteolytic cleavages, the R970C MET variant favors calpain dependent proteolytic cleavage in lung cancer cells.

  5. FBLN-3 (show FBLN3 Proteins) promoter region was highly methylated in some pancreatic cancer cell lines. FBLN-3 (show FBLN3 Proteins) inhibited c-MET activation and expression and reduced cellular level of ALDH1 (show ALDH1A1 Proteins).

  6. The authors elucidate that MET promotes glioblastoma stem-like cell radioresistance through a novel mechanism, relying on AKT (show AKT1 Proteins) activity and leading to (i) sustained activation of Aurora kinase A (show AURKA Proteins), ATM (show ATM Proteins) kinase, and the downstream effectors of DNA repair, and (ii) phosphorylation and cytoplasmic retention of p21 (show CDKN1A Proteins), which is associated with anti-apoptotic functions.

  7. The MET mutation is involved in the pathogenesis of EGFR (show EGFR Proteins)-mutant lung cancer.

  8. These results establish HGF/C-Met as a central organizing signal in blood vessel-directed tumor cell migration in vivo and highlight a promising role for C-Met inhibitors in blocking tumor cell streaming and metastasis in vivo, and for use in human trials.

  9. Study provide evidence that HGFR plays a role in colorectal tumorigenesis. Its phosphorylation seems to be under the influence of miR (show MLXIP Proteins)-141, a tumor suppressor gene.

  10. In personalized therapies against bone metastasis, we suggest miR (show MLXIP Proteins)-34a-5p as a suitable target of epigenetic reprogramming leading to the accumulation of miR (show MLXIP Proteins)-34a-5p and the down-regulation of Met-tyrosine kinase (show TXK Proteins), a key player of the bone-metastatic process.

Mouse (Murine) Met Proto-Oncogene (MET) interaction partners

  1. a c-Met/ETS-1 (show ETS1 Proteins)/matrix metalloproteinase-14 (MMP-14 (show MMP14 Proteins)) axis that controls VE-cadherin (show CDH5 Proteins) degradation, endothelial mesenchymal transition, and vascular abnormality.

  2. We found the roles of hepatocyte growth factor (HGF (show HGF Proteins)) signaling in stria vascularis development for the first time and that lack of HGF (show HGF Proteins) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (show HGF Proteins) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva

  3. c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.

  4. In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS (show RALGDS Proteins) at Y752 in its RBD (show CACNA1D Proteins), which blocks the binding of Ras to RalGDS (show RALGDS Proteins).

  5. study demonstrates that co-activation of AKT (show AKT1 Proteins) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN (show FASN Proteins) pathway.

  6. Molecular and functional studies revealed that ectopic Met expression in limb mesenchyme does not alter HGF (show HGF Proteins) expression patterns and levels, but impairs HGF (show HGF Proteins) bioavailability

  7. miR-206 suppressed c-Met expression in gastric cancer and could function as a potent tumor suppressor in c-Met overexpressing tumors.

  8. Meg3 overexpression in insulinoma cells down-regulated the expression of the protooncogene c-met.

  9. our results support the concept of the acrosome as a lysosome-related organelle and provide evidence for the identification of MET as a tyrosine kinase receptor (show KDR Proteins) that may play a role in fertilization.

  10. We show that a subset of adult calcitonin gene-related peptide (CGRP (show CALCA Proteins))-expressing myenteric neurons produce MET, the receptor for hepatocyte growth factor (show HGF Proteins).

Cow (Bovine) Met Proto-Oncogene (MET) interaction partners

  1. possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

MET Protein Profile

Protein Summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MET

  • met proto-oncogene (MET)
  • met proto-oncogene (Met)
  • met proto-oncogene (hepatocyte growth factor receptor) (MET)
  • AI838057 protein
  • AUTS9 protein
  • c-met protein
  • HGF protein
  • Hgfr protein
  • Par4 protein
  • RCCP2 protein

Protein level used designations for Met Proto-Oncogene Proteins (MET)

HGF receptor , HGF/SF receptor , SF receptor , hepatocyte growth factor receptor , met proto-oncogene tyrosine kinase , proto-oncogene c-Met , scatter factor receptor , tyrosine-protein kinase Met , c-Met , HGF receptor c-Met

4233 Homo sapiens
17295 Mus musculus
24553 Rattus norvegicus
403438 Canis lupus familiaris
280855 Bos taurus
654328 Sus scrofa
100126565 Oryctolagus cuniculus
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