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Browse our MME Proteins (MME)

Full name:
Membrane Metallo-Endopeptidase Proteins (MME)
On are 34 Membrane Metallo-Endopeptidase (MME) Proteins from 13 different suppliers available. Additionally we are shipping MME Antibodies (486) and MME Kits (41) and many more products for this protein. A total of 584 MME products are currently listed.
6030454K05Rik, AV378681, C85356, CAK, CALLA, CD10, CD167, DDR, EDDR1, HGK2, MCK10, MME, Mmel, Nep, NTRK4, PTK3, PTK3A, RTK6, SFE, TRKE
list all proteins Gene Name GeneID UniProt
MME 780 Q08345
MME 17381 P34960
MME 24590 P07861

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MME Proteins (MME) by Origin

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Top referenced MME Proteins

  1. Mouse (Murine) MME Protein expressed in Human Cells - ABIN2007528 : Oefner, DArcy, Hennig, Winkler, Dale: Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. in Journal of molecular biology 2000 (PubMed)
    Show all 5 references for ABIN2007528

  2. Rat (Rattus) MME Protein expressed in Human Cells - ABIN2009438 : Iwata, Tsubuki, Takaki, Shirotani, Lu, Gerard, Gerard, Hama, Lee, Saido: Metabolic regulation of brain Abeta by neprilysin. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 5 references for ABIN2009438

  3. Human MME Protein expressed in HEK-293 Cells - ABIN2181507 : Pardossi-Piquard, Dunys, Yu, St George-Hyslop, Alves da Costa, Checler: Neprilysin activity and expression are controlled by nicastrin. in Journal of neurochemistry 2006 (PubMed)
    Show all 4 references for ABIN2181507

  4. Cynomolgus MME Protein expressed in Human Cells - ABIN2009952 : Chen, Salles, Seldin, Kister, Reinherz, Shipp: Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)
    Show all 4 references for ABIN2009952

  5. Human MME Protein expressed in Human Cells - ABIN2003415 : Le Moual, Dion, Roques, Crine, Boileau: Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. in European journal of biochemistry / FEBS 1994 (PubMed)
    Show all 4 references for ABIN2003415

  6. Human MME Protein expressed in HEK-293 Cells - ABIN2181505 : Goodman, Febbraio, Simantov, Zheng, Shen, Silverstein, Nanus: Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. in The Journal of biological chemistry 2006 (PubMed)
    Show all 3 references for ABIN2181505

More Proteins for MME Interaction Partners

Pig (Porcine) Membrane Metallo-Endopeptidase (MME) interaction partners

  1. Neutral endopeptidase 24.11 and DPP-IV (show DPP4 Proteins) is superior to DPP-IV (show DPP4 Proteins) inhibition alone in preserving intact GLP-1 (show GCG Proteins), which implies possibility that the combination has therapeutic potential.

  2. This study provides evidence that NEP 24.11 is an important mediator of the degradation of both endogenous and exogenous glucagon (show GCG Proteins) in vivo.

Human Membrane Metallo-Endopeptidase (MME) interaction partners

  1. CD10 and Bcl2 (show BCL2 Proteins) expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis

  2. The peptide qf-Abeta (show APP Proteins)(12-18)C (sequence VHHQKLVC) was cleaved by multiple Abeta (show APP Proteins)-degrading enzymes, including NEP, ACE (show ACE Proteins), and ECE-1 (show ECE1 Proteins), whereas the redesigned peptide qf-Abeta (show APP Proteins)(12-16)AAC (show GLYAT Proteins) (sequence VHHQKAAC) was sensitive to NEP and ACE (show ACE Proteins) only.

  3. Loss-of-function MME mutations are the most frequent cause of adult-onset autosomal-recessive Charcot-Marie-Tooth disease type 2 in Japan.

  4. CD10 positivity is luminal/membranous in most benign apocrine breast lesions, the staining being nonuniversal and sometimes focal; analogous staining in apocrine malignancies seems rarer in DCIS and even rarer in invasive apocrine carcinomas, but atypical cytoplasmic positivity may also occur

  5. Knockdown DDR1 (show DDR1 Proteins) reversed the effects of Galpha13 (show GNA13 Proteins) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.

  6. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2 (show DDR2 Proteins)) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl (show KRT7 Proteins)-like proteins that inhibit collagen-DDR (show DDR1 Proteins) interactions and macrophage migration.

  7. DDR1 (show DDR1 Proteins) is a key modulator of RIT (show RIT1 Proteins) activity.

  8. These findings indicate that CD10 may promote tumor progression by regulating the expression profiles of genes related to cell proliferation, angiogenesis, and resistance to apoptosis.

  9. CD10 gene expression plays a role in the pathogenesis of diffuse large B-cell lymphoma.

  10. High tumoral CD10 expression correlates with aggressive histology in patients with malignant pleural mesothelioma.

Mouse (Murine) Membrane Metallo-Endopeptidase (MME) interaction partners

  1. These results suggest that MMP-12 (show MMP12 Proteins) production during emphysema exacerbation results in increased mortality and disease progression.

  2. study found significant increases of MMP-3 (show MMP3 Proteins) and MMP-12 (show MMP12 Proteins) mRNA levels and MMP12 (show MMP12 Proteins) zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  3. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12 (show MMP12 Proteins), and the activation of PAR2 (show F2RL1 Proteins) might be related to MMP-12 (show MMP12 Proteins) production.

  4. MMP-12 (show MMP12 Proteins) up-regulation mediated by SARM (show SARM1 Proteins)-TRIF (show RNF138 Proteins) signaling pathway contributes to IFN-gamma (show IFNG Proteins)-independent airway inflammation and AHR (show AHR Proteins) post RSV infection in nude mice.

  5. MMP-12 (show MMP12 Proteins) and MMP-13 (show MMP13 Proteins) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  6. Amyloid beta (Abeta (show APP Proteins))-degrading effects of overexpressed neprilysin can block deleterious BACE1 (show BACE Proteins)-elevating mechanisms that accelerate Abeta (show APP Proteins) production

  7. Post-MI, MMP-12i impaired CD44 (show CD44 Proteins)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.

  8. MMP12 (show MMP12 Proteins) upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 (show MMP12 Proteins) in the neuronal initiation of the synaptic stripping process

  9. abnormal neuronal expression of matrix metalloproteinase-12 (show MMP12 Proteins) may contribute to axonal degeneration in Niemann-Pick type C disease

  10. the results of this study show a close correlation between vascular injury markers, Arg 1 (show ARG1 Proteins)+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 (show MMP12 Proteins) in regulating these processes.

MME Protein Profile

Protein Summary

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Alternative names and synonyms associated with MME

  • membrane metallo-endopeptidase (MME)
  • discoidin domain receptor tyrosine kinase 1 (DDR1)
  • matrix metallopeptidase 12 (Mmp12)
  • membrane metallo endopeptidase (Mme)
  • membrane metallo-endopeptidase (Mme)
  • 6030454K05Rik protein
  • AV378681 protein
  • C85356 protein
  • CAK protein
  • CALLA protein
  • CD10 protein
  • CD167 protein
  • DDR protein
  • EDDR1 protein
  • HGK2 protein
  • MCK10 protein
  • MME protein
  • Mmel protein
  • Nep protein
  • NTRK4 protein
  • PTK3 protein
  • PTK3A protein
  • RTK6 protein
  • SFE protein
  • TRKE protein

Protein level used designations for MME

membrane metallo-endopeptidase , enkephalinase , neutral endopeptidase , membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) , membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) , neprilysin , neprilysin-410 short isoform , CD167 antigen-like family member A , PTK3A protein tyrosine kinase 3A , cell adhesion kinase , epithelial discoidin domain-containing receptor 1 , mammary carcinoma kinase 10 , neuroepithelial tyrosine kinase , neurotrophic tyrosine kinase, receptor, type 4 , protein-tyrosine kinase RTK-6 , tyrosine kinase DDR , tyrosine-protein kinase CAK , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase 12 , matrix metalloproteinase-12 , atriopeptidase , common acute lymphoblastic leukemia antigen , neutral endopeptidase 24.11 , skin fibroblast elastase , common acute lymphocytic leukemia antigen , membrane metallo-endopeptidase variant 1 , membrane metallo-endopeptidase variant 2 , membrane metallo endopeptidase , membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase) , NEP

497058 Sus scrofa
425031 Gallus gallus
477120 Canis lupus familiaris
780 Homo sapiens
17381 Mus musculus
17380 Mus musculus
4311 Homo sapiens
24590 Rattus norvegicus
100511536 Sus scrofa
100009251 Oryctolagus cuniculus
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