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Browse our MST1R Proteins (MST1R)

Full name:
Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) Proteins (MST1R)
On are 16 Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) Proteins from 6 different suppliers available. Additionally we are shipping MST1R Antibodies (192) and MST1R Kits (7) and many more products for this protein. A total of 221 MST1R products are currently listed.
CD136, Cdw136, Fv-2, Fv2, Ptk8, Ron, Stk
list all proteins Gene Name GeneID UniProt
MST1R 4486 Q04912
MST1R 19882 Q62190
Rat MST1R MST1R 300999  

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Human Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) interaction partners

  1. complete loss of one or both MET and RON, as well as their overexpression, is a poor prognostic factor in patients with extrahepatic cholangiocarcinoma, probably due to the high rate of lymph-node metastasis

  2. Study identified four novel uniquely spliced RON transcripts in small cell lung carcinoma (SCLC) and Non-SCLC cell lines.

  3. the MST1R variant c.G917A:p.R306H is highly associated with nasopharyngeal carcinoma (odds ratio of 9.0).

  4. Results show that under hypoxia, nuclear RON activates non-homologous end joining DNA repair by interacting with Ku70 (show XRCC6 Proteins) and DNA-PKcs (show PRKDC Proteins) and confers chemoresistance.

  5. Aberrant glycosylation of the RON receptor was shown as an alternative mechanism of oncogenic activation.

  6. Data demonstrated upregulated RON isoform expression and significant changes in splicing factor (show SLU7 Proteins) expression in primary ovarian cancer suggesting a regulatory interplay of splicing factor (show SLU7 Proteins) and RON alternative splicing pattern in ovarian cancer.

  7. Activation of RON as an alternate mechanism in the development of CRPC.

  8. the prognostic significance of MET is limited in early stage disease. MET+/RON+ patients had higher overall recurrence rates than those with the other expression patterns

  9. RON expression in endometrial adenocarcinoma was significantly higher than that in normal endometrial tissues.

  10. Studies demonstrate that DEK (show DEK Proteins) overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

Mouse (Murine) Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) interaction partners

  1. Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia.

  2. Ron knockdown further sensitized breast cancer cells to the growth inhibitory effects of vitamin D3, while constitutive activation of beta-catenin (show CTNNB1 Proteins) reverted the effects of vitamin D3.

  3. Studies demonstrate that DEK (show DEK Proteins) overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. A previously unknown function for the Ron receptor in mediating High Fat Diet-induced obesity and metabolic dysregulation.

  5. important functional roles for Ron in inflammatory bowel diseases by regulating healing of the colonic epithelium and by controlling cytokine secretion

  6. DC-STAMP, Siglec-15 (show SIGLEC15 Proteins), Tspan7 (show TSPAN7 Proteins) and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.

  7. Stem cell-derived tyrosine kinase plays a role in regulating macrophage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity.

  8. studies show a critical role for the Ron receptor in the tumor microenvironment, whereby Ron loss in tumor-associated macrophages inhibits prostate cancer cell growth, at least in part, by derepressing the activity of CD8 (show CD8A Proteins)(+) T cells

  9. Identify a novel signaling mechanism by which the Ron receptor regulates acute liver failure progression.

  10. Data suggest an important role for beta-catenin (show CTNNB1 Proteins) downstream of Ron receptor signaling during the development of mammary tumorigenesis.

MST1R Protein Profile

Protein Summary

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).

Alternative names and synonyms associated with MST1R

  • macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R)
  • macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (Mst1r)
  • CD136 protein
  • Cdw136 protein
  • Fv-2 protein
  • Fv2 protein
  • Ptk8 protein
  • Ron protein
  • Stk protein

Protein level used designations for MST1R

MSP receptor , MST1R variant RON30 , MST1R variant RON62 , PTK8 protein tyrosine kinase 8 , RON variant 21 , RON variant E2E3 , c-met-related tyrosine kinase , macrophage-stimulating protein receptor , p185-Ron , soluble RON variant 1 , soluble RON variant 2 , soluble RON variant 3 , soluble RON variant 4 , friend virus susceptibility 2 , macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) , receptor protein tyrosine kinase, c-met-related , stem cell-derived tyrosine kinase , protein tyrosine kinase 8 , tyrosine kinase receptor ron

4486 Homo sapiens
19882 Mus musculus
300999 Rattus norvegicus
444854 Canis lupus familiaris
100626292 Sus scrofa
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