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Nap1 is a constitutive and essential component of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
Inhibition of Nap1, a member of the WAVE actin-remodeling complex, results in accumulations of F-actin structures at the plasma membrane that are concomitant with a decrease in myoblast fusion.
interacts with Nck and may be involved in the downstream signaling of Nck
membrane-associated protein HEM-2
, nck-associated protein 1
, NAP 1
, brain protein H19