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Browse our PDGFB Proteins (PDGFB)

Full name:
Platelet-Derived Growth Factor beta Polypeptide Proteins (PDGFB)
On are 41 Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Proteins from 15 different suppliers available. Additionally we are shipping PDGFB Antibodies (87) and PDGFB Kits (62) and many more products for this protein. A total of 197 PDGFB products are currently listed.
c-sis, PDGF-2, PDGF-B, PDGF2, SIS, SSV
list all proteins Gene Name GeneID UniProt
PDGFB 18591 P31240
PDGFB 5155 P01127
PDGFB 24628 Q05028

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PDGFB Proteins (PDGFB) by Origin

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Top referenced PDGFB Proteins

  1. Human PDGFB Protein expressed in HEK-293 Cells - ABIN2181626 : Chen, Cai, Zhang, Liu, Liu: Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. in Experimental and therapeutic medicine 2014 (PubMed)
    Show all 2 references for ABIN2181626

More Proteins for PDGFB Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.

  2. data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Proteins) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells

  3. loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.

  4. Results suggest that regional Pax3 (show PAX3 Proteins) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis

  5. High PDGFB expression is associated with liver fibrosis.

  6. Increased expression of STAT5b (show STAT5B Proteins) + PDGFB led to increased expression of downstream STAT5b (show STAT5B Proteins) targets.

  7. Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (show ABCB4 Proteins)-null mice.

  8. The endogenous levels of PDGF (show PDGFA Proteins)-BB, increases CD31 (show PECAM1 Proteins)(hi)endomucin (show EMCN Proteins)(hi) vessel number and stimulates bone formation in ovariectomy mice.

  9. These findings thus implicate a novel role of PDGF (show PDGFA Proteins)-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier

  10. The data indicate a dual role of Lhx2 (show LHX2 Proteins) during EMT (show ITK Proteins) and tumor progression: by inducing the expression of PDGF-B, Lhx2 (show LHX2 Proteins) provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination

Human Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. A cell-autonomous positive-signaling circuit is associated with the PDGF (show PDGFA Proteins)-NO-ID4 (show ID4 Proteins)-regulatory axis in glioblastoma cells.

  2. SphK1 (show SPHK1 Proteins) is regulated by PDGF (show PDGFA Proteins)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Proteins), promoting cell proliferation.

  3. PDGF (show PDGFA Proteins)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.

  4. Low concentration of PDGF (show PDGFA Proteins)-AB showed synergism with IFN-alpha (show IFNA Proteins) in IFN-beta (show IFNB1 Proteins) and -gamma induction.

  5. There are four platelet-derived growth factor (PDGF (show PDGFA Proteins)) genes (PDGFA (show PDGFA Proteins), PDGFB, PDGFC (show PDGFC Proteins) and PDGFD (show PDGFD Proteins)) that reside on chromosomes 7, 22, 4 and 11.

  6. this study shows that the expression of PDGFB is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts

  7. this study demonstrated that knockdown of SCARA5 (show SCARA5 Proteins) inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF (show PDGFA Proteins) signaling pathway.

  8. The simultaneous action of PDGF-B/PDGFRbeta and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRbeta phosphorylation.

  9. The expression of angiogenesis markers VEGF-A (show VEGFA Proteins), VEGFR (show KDR Proteins), PDGFbetabeta, PDGFR (show PDGFRB Proteins), CCND1 (show CCND1 Proteins) and CA9 (show CA9 Proteins) was assessed by immunohistochemistry and correlated with overall survival and progression-free survival in patients with renal cell carcinoma (show MOK Proteins) undergoing therapy with Sunitinib, but no correlation was found between expression of angiogenesis markers and clinical outcome.

  10. ore than 65% of cases had PDGF (show PDGFA Proteins)-BB mRNA amplification, confirming immunohistochemical results. We herein validated PDGF (show PDGFA Proteins)-BB as a potential therapeutic and prognostic tool of ovarian cancer aggressiveness.

Cow (Bovine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Proteins)/Stat3 (show STAT3 Proteins) signaling pathway.

  2. PDGF-B transcription is increased by Nuclear Factor Kappa B

  3. up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Proteins)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation

  4. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  5. Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.

PDGFB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • platelet derived growth factor, B polypeptide (Pdgfb)
  • platelet-derived growth factor beta polypeptide (Pdgfb)
  • c-sis protein
  • PDGF-2 protein
  • PDGF-B protein
  • PDGF2 protein
  • SIS protein
  • SSV protein

Protein level used designations for PDGFB

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , PDGF subunit B , PDGF-2 , c-sis , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide , platelet-derived growth factor subunit B , proto-oncogene c-Sis , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor, beta polypeptide (oncogene SIS) , Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis) , pdgf protein , platelet derived growth factor, B polypeptide , platelet-derived growth factor B , v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog) , platelet-derived growth factor B subunit

100228287 Taeniopygia guttata
18591 Mus musculus
5155 Homo sapiens
24628 Rattus norvegicus
100126843 Sus scrofa
442986 Canis lupus familiaris
540106 Bos taurus
100731469 Cavia porcellus
374128 Gallus gallus
443545 Ovis aries
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