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Browse our PDGFB Proteins (PDGFB)

Full name:
Platelet-Derived Growth Factor beta Polypeptide Proteins (PDGFB)
On www.antibodies-online.com are 35 Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Proteins from 13 different suppliers available. Additionally we are shipping PDGFB Antibodies (106) and PDGFB Kits (52) and many more products for this protein. A total of 200 PDGFB products are currently listed.
Synonyms:
c-sis, PDGF-2, PDGF-B, PDGF2, SIS, SSV
list all proteins Gene Name GeneID UniProt
PDGFB 18591 P31240
PDGFB 5155 P01127
PDGFB 24628 Q05028

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PDGFB Proteins (PDGFB) by Origin

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Top referenced PDGFB Proteins

  1. Human PDGFB Protein expressed in HEK-293 Cells - ABIN2181626 : Chen, Cai, Zhang, Liu, Liu: Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. in Experimental and therapeutic medicine 2014 (PubMed)
    Show all 2 references for ABIN2181626

More Proteins for PDGFB Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.

  2. Results suggest that regional Pax3 (show PAX3 Proteins) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis

  3. High PDGFB expression is associated with liver fibrosis.

  4. Increased expression of STAT5b (show STAT5B Proteins) + PDGFB led to increased expression of downstream STAT5b (show STAT5B Proteins) targets.

  5. Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (show ABCB4 Proteins)-null mice.

  6. The endogenous levels of PDGF (show PDGFA Proteins)-BB, increases CD31 (show PECAM1 Proteins)(hi)endomucin (show EMCN Proteins)(hi) vessel number and stimulates bone formation in ovariectomy mice.

  7. These findings thus implicate a novel role of PDGF (show PDGFA Proteins)-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier

  8. The data indicate a dual role of Lhx2 (show LHX2 Proteins) during EMT (show ITK Proteins) and tumor progression: by inducing the expression of PDGF-B, Lhx2 (show LHX2 Proteins) provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination

  9. The signaling pathways of VEGF (show VEGFA Proteins) and PDGF (show PDGFA Proteins) are crucial mediators for determining proliferation of endothelial cells and oligodendrocytes in the neurohypophysis of adult mice.

  10. Our findings demonstrate, for the first time, that Shh (show SHH Proteins) is involved in PDGF (show PDGFA Proteins)-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels

Human Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. Case Report: congenital atrophic dermatofibrosarcoma protuberans with COL1A1-PDGFB rearrangement.

  2. Loss of Nf2 (show NF2 Proteins) and Cdkn2a/b have synergistic effects with PDGF-B overexpression promoting meningioma malignant transformation.

  3. Human uPAR (show PLAUR Proteins) activation and its association with beta1-integrin are required for PDGF (show PDGFA Proteins)-AB-induced migration.

  4. Placental endothelial cell-derived PDGF (show PDGFA Proteins)-BB recruits human placental multipotent mesenchymal stromal cells involved in vascular development via PDGFR-beta (show PDGFRB Proteins)/STAT3 (show STAT3 Proteins) activation

  5. Suggest that PDGF-B signaling may play a role in endothelial and cardiomyocyte recovery from ischemia reperfusion injury after heart transplantation.

  6. Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriers. Three causative genes have been identified: SLC20A2, PDGFRB and, recently, PDGFB, whose associated phenotype has not yet been extensively studied.

  7. loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.

  8. Three factor model revealed significant gene-gene interaction for PDGFB +286A>G, PDGFB +1135A>C and HER2 (show ERBB2 Proteins) Ile165Val SNPs with GBC. Protein-protein interaction showed significant association of PDGFB and HER2 (show ERBB2 Proteins) with EGFR (show EGFR Proteins) receptor signaling pathway.

  9. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.

  10. Electron microscopy structure of PDGFRB (show PDGFRB Proteins) [a full-length human platelet-derived growth factor receptor (show PDGFRL Proteins)], in complex with its ligand PDGF-B.

Pig (Porcine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. Data indicate a significant impairment of the activation mechanisms by PDGF (show PDGFA Proteins)-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta (show PDGFRB Proteins) was applied.

Cow (Bovine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

  1. Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Proteins)/Stat3 (show STAT3 Proteins) signaling pathway.

  2. PDGF-B transcription is increased by Nuclear Factor Kappa B

  3. up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Proteins)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation

  4. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  5. Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.

PDGFB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • platelet derived growth factor, B polypeptide (Pdgfb)
  • platelet-derived growth factor beta polypeptide (Pdgfb)
  • c-sis protein
  • PDGF-2 protein
  • PDGF-B protein
  • PDGF2 protein
  • SIS protein
  • SSV protein

Protein level used designations for PDGFB

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , PDGF subunit B , PDGF-2 , c-sis , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide , platelet-derived growth factor subunit B , proto-oncogene c-Sis , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor, beta polypeptide (oncogene SIS) , Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis) , pdgf protein , platelet derived growth factor, B polypeptide , platelet-derived growth factor B , v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog) , platelet-derived growth factor B subunit

GENE ID SPECIES
100228287 Taeniopygia guttata
18591 Mus musculus
5155 Homo sapiens
24628 Rattus norvegicus
100126843 Sus scrofa
442986 Canis lupus familiaris
540106 Bos taurus
100731469 Cavia porcellus
374128 Gallus gallus
443545 Ovis aries
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