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Human PDGFB Protein expressed in HEK-293 Cells - ABIN2181626
Chen, Cai, Zhang, Liu, Liu: Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. in Experimental and therapeutic medicine 2014
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PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.
PDAP-1 (show PDAP1 Proteins) as an effecter of PDGF (show PDGFA Proteins) signaling in glioma cells
High PDGFB expression is associated with gastric cancer.
We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (show DMD Proteins) patients expressed PDGF (show PDGFA Proteins)-BB.
Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma (show MOK Proteins).
Insulin (show INS Proteins) treatment caused sustained Akt (show AKT1 Proteins) activity, whereas EGF (show EGF Proteins) or PDGF (show PDGFA Proteins)-AA promoted transient signaling; PDGF (show PDGFA Proteins)-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Proteins) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Proteins) caused full Akt (show AKT1 Proteins) activation
high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.
High PDGFB expression is associated with glioma.
A cell-autonomous positive-signaling circuit is associated with the PDGF (show PDGFA Proteins)-NO-ID4 (show ID4 Proteins)-regulatory axis in glioblastoma cells.
SphK1 (show SPHK1 Proteins) is regulated by PDGF (show PDGFA Proteins)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Proteins), promoting cell proliferation.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Proteins)/Stat3 (show STAT3 Proteins) signaling pathway.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Proteins)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Proteins), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Proteins), FGF-2 (show FGF2 Proteins) and PDGF (show PDGFA Proteins)-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Proteins) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 (show PAX3 Proteins) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Increased expression of STAT5b (show STAT5B Proteins) + PDGFB led to increased expression of downstream STAT5b (show STAT5B Proteins) targets.
Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (show ABCB4 Proteins)-null mice.
The endogenous levels of PDGF (show PDGFA Proteins)-BB, increases CD31 (show PECAM1 Proteins)(hi)endomucin (show EMCN Proteins)(hi) vessel number and stimulates bone formation in ovariectomy mice.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit