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Browse our PDGFBB Proteins (PDGFBB)

Full name:
Platelet Derived Growth Factor BB Proteins (PDGFBB)
On are 57 Platelet Derived Growth Factor BB (PDGFBB) Proteins from 13 different suppliers available. Additionally we are shipping PDGFBB Antibodies (70) and PDGFBB Kits (67) and many more products for this protein. A total of 194 PDGFBB products are currently listed.
c-sis, PDGF-2, PDGF2, SIS, SSV
list all proteins Gene Name GeneID UniProt
PDGFBB 5155 P01127

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PDGFBB Proteins (PDGFBB) by Origin

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Top referenced PDGFBB Proteins

  1. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2667569 : Ustach, Kim: Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. in Molecular and cellular biology 2005 (PubMed)
    Show all 5 references for ABIN2667569

  2. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2666565 : Risinger, Updike, Bullen, Tomasek, Howard: TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. in American journal of physiology. Cell physiology 2009 (PubMed)
    Show all 5 references for ABIN2666565

  3. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413706 : Tsuchida, Schneider, Pizani, Oliveira: Lead and aluminum bonding in Pb-AI metaphosphate glasses. in Inorganic chemistry 2008 (PubMed)

  4. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413709 : Hamada, Gonda, Takeda, Sato, Watanabe, Yambe, Satomi, Ohuchi: In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. in Blood 2011 (PubMed)

  5. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN1589629 : Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015 (PubMed)

More Proteins for PDGFBB Interaction Partners

Human Platelet Derived Growth Factor BB (PDGFBB) interaction partners

  1. A cell-autonomous positive-signaling circuit is associated with the PDGF (show PDGFA Proteins)-NO-ID4 (show ID4 Proteins)-regulatory axis in glioblastoma cells.

  2. SphK1 (show SPHK1 Proteins) is regulated by PDGF (show PDGFA Proteins)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Proteins), promoting cell proliferation.

  3. PDGF (show PDGFA Proteins)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.

  4. Low concentration of PDGF (show PDGFA Proteins)-AB showed synergism with IFN-alpha (show IFNA Proteins) in IFN-beta (show IFNB1 Proteins) and -gamma induction.

  5. There are four platelet-derived growth factor (PDGF (show PDGFA Proteins)) genes (PDGFA (show PDGFA Proteins), PDGFB (show PDGFB Proteins), PDGFC (show PDGFC Proteins) and PDGFD (show PDGFD Proteins)) that reside on chromosomes 7, 22, 4 and 11.

  6. this study shows that the expression of PDGFB is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts

  7. this study demonstrated that knockdown of SCARA5 (show SCARA5 Proteins) inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF (show PDGFA Proteins) signaling pathway.

  8. The simultaneous action of PDGF-B (show PDGFB Proteins)/PDGFRbeta and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRbeta phosphorylation.

  9. The expression of angiogenesis markers VEGF-A (show VEGFA Proteins), VEGFR (show KDR Proteins), PDGFbetabeta, PDGFR (show PDGFRB Proteins), CCND1 (show CCND1 Proteins) and CA9 (show CA9 Proteins) was assessed by immunohistochemistry and correlated with overall survival and progression-free survival in patients with renal cell carcinoma (show MOK Proteins) undergoing therapy with Sunitinib, but no correlation was found between expression of angiogenesis markers and clinical outcome.

  10. ore than 65% of cases had PDGF (show PDGFA Proteins)-BB mRNA amplification, confirming immunohistochemical results. We herein validated PDGF (show PDGFA Proteins)-BB as a potential therapeutic and prognostic tool of ovarian cancer aggressiveness.

PDGFBB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFBB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • c-sis protein
  • PDGF-2 protein
  • PDGF2 protein
  • SIS protein
  • SSV protein

Protein level used designations for PDGFBB

PDGF subunit B , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , platelet-derived growth factor subunit B , platelet-derived growth factor, beta polypeptide (oncogene SIS) , proto-oncogene c-Sis

5155 Homo sapiens
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