Browse our PDGFBB Proteins (PDGFBB)

Full name:
Platelet Derived Growth Factor BB Proteins (PDGFBB)
On are 59 Platelet Derived Growth Factor BB (PDGFBB) Proteins from 14 different suppliers available. Additionally we are shipping PDGFBB Kits (70) and PDGFBB Antibodies (70) and many more products for this protein. A total of 199 PDGFBB products are currently listed.
c-sis, PDGF-2, PDGF2, SIS, SSV
list all proteins Gene Name GeneID UniProt
PDGFBB 5155 P01127

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PDGFBB Proteins (PDGFBB) by Origin

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Top referenced PDGFBB Proteins

  1. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2666565 : Risinger, Updike, Bullen, Tomasek, Howard: TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. in American journal of physiology. Cell physiology 2009 (PubMed)
    Show all 5 references for 2666565

  2. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2667569 : Ustach, Kim: Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. in Molecular and cellular biology 2005 (PubMed)
    Show all 5 references for 2667569

  3. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN1590225 : Lim, Moon, Shin, Kim, Cho, Kim, Park, Choi, Ko, Chung, Lee, Jang, Kim, Park: Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats. in Cardiovascular research 2011 (PubMed)

  4. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413706 : Tsuchida, Schneider, Pizani, Oliveira: Lead and aluminum bonding in Pb-AI metaphosphate glasses. in Inorganic chemistry 2008 (PubMed)

  5. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN1589629 : Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015 (PubMed)

  6. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413709 : Hamada, Gonda, Takeda, Sato, Watanabe, Yambe, Satomi, Ohuchi: In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. in Blood 2011 (PubMed)

More Proteins for PDGFBB Interaction Partners

Human Platelet Derived Growth Factor BB (PDGFBB) interaction partners

  1. We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (show DMD Proteins) patients expressed PDGF (show PDGFA Proteins)-BB.

  2. Elevated PDGFB (show PDGFB Proteins) expression was noted in 29% of patients with papillary renal cell carcinoma (show MOK Proteins).

  3. Insulin (show INS Proteins) treatment caused sustained Akt (show AKT1 Proteins) activity, whereas EGF (show EGF Proteins) or PDGF (show PDGFA Proteins)-AA promoted transient signaling; PDGF (show PDGFA Proteins)-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Proteins) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Proteins) caused full Akt (show AKT1 Proteins) activation

  4. high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.

  5. High PDGFB expression is associated with glioma.

  6. A cell-autonomous positive-signaling circuit is associated with the PDGF (show PDGFA Proteins)-NO-ID4 (show ID4 Proteins)-regulatory axis in glioblastoma cells.

  7. SphK1 (show SPHK1 Proteins) is regulated by PDGF (show PDGFA Proteins)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Proteins), promoting cell proliferation.

  8. PDGF (show PDGFA Proteins)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.

  9. Low concentration of PDGF (show PDGFA Proteins)-AB showed synergism with IFN-alpha (show IFNA Proteins) in IFN-beta (show IFNB1 Proteins) and -gamma induction.

  10. There are four platelet-derived growth factor (PDGF (show PDGFA Proteins)) genes (PDGFA (show PDGFA Proteins), PDGFB (show PDGFB Proteins), PDGFC (show PDGFC Proteins) and PDGFD (show PDGFD Proteins)) that reside on chromosomes 7, 22, 4 and 11.

PDGFBB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFBB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • c-sis protein
  • PDGF-2 protein
  • PDGF2 protein
  • SIS protein
  • SSV protein

Protein level used designations for PDGFBB

PDGF subunit B , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , platelet-derived growth factor subunit B , platelet-derived growth factor, beta polypeptide (oncogene SIS) , proto-oncogene c-Sis

5155 Homo sapiens
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