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Browse our PDGFBB Proteins (PDGFBB)

Full name:
Platelet Derived Growth Factor BB Proteins (PDGFBB)
On are 65 Platelet Derived Growth Factor BB (PDGFBB) Proteins from 14 different suppliers available. Additionally we are shipping PDGFBB Kits (56) and PDGFBB Antibodies (48) and many more products for this protein. A total of 169 PDGFBB products are currently listed.
c-sis, PDGF-2, PDGF2, SIS, SSV
list all proteins Gene Name GeneID UniProt
PDGFBB 5155 P01127

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PDGFBB Proteins (PDGFBB) by Origin

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Top referenced PDGFBB Proteins

  1. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2666565 : Risinger, Updike, Bullen, Tomasek, Howard: TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. in American journal of physiology. Cell physiology 2009 (PubMed)
    Show all 5 references for ABIN2666565

  2. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN2667569 : Ustach, Kim: Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. in Molecular and cellular biology 2005 (PubMed)
    Show all 5 references for ABIN2667569

  3. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413706 : Tsuchida, Schneider, Pizani, Oliveira: Lead and aluminum bonding in Pb-AI metaphosphate glasses. in Inorganic chemistry 2008 (PubMed)

  4. Human PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN1589629 : Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015 (PubMed)

  5. Mouse (Murine) PDGFBB Protein expressed in Escherichia coli (E. coli) - ABIN413709 : Hamada, Gonda, Takeda, Sato, Watanabe, Yambe, Satomi, Ohuchi: In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia. in Blood 2011 (PubMed)

More Proteins for PDGFBB Interaction Partners

Human Platelet Derived Growth Factor BB (PDGFBB) interaction partners

  1. this study shows that the expression of PDGFB is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts

  2. this study demonstrated that knockdown of SCARA5 (show SCARA5 Proteins) inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF (show PDGFA Proteins) signaling pathway.

  3. The simultaneous action of PDGF-B (show PDGFB Proteins)/PDGFRbeta and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRbeta phosphorylation.

  4. The expression of angiogenesis markers VEGF-A (show VEGFA Proteins), VEGFR (show KDR Proteins), PDGFbetabeta, PDGFR (show PDGFRB Proteins), CCND1 (show CCND1 Proteins) and CA9 (show CA9 Proteins) was assessed by immunohistochemistry and correlated with overall survival and progression-free survival in patients with renal cell carcinoma (show MOK Proteins) undergoing therapy with Sunitinib, but no correlation was found between expression of angiogenesis markers and clinical outcome.

  5. ore than 65% of cases had PDGF (show PDGFA Proteins)-BB mRNA amplification, confirming immunohistochemical results. We herein validated PDGF (show PDGFA Proteins)-BB as a potential therapeutic and prognostic tool of ovarian cancer aggressiveness.

  6. Case Report: congenital atrophic dermatofibrosarcoma protuberans with COL1A1-PDGFB rearrangement.

  7. Loss of Nf2 (show NF2 Proteins) and Cdkn2a/b have synergistic effects with PDGF-B (show PDGFB Proteins) overexpression promoting meningioma malignant transformation.

  8. Human uPAR (show PLAUR Proteins) activation and its association with beta1-integrin are required for PDGF (show PDGFA Proteins)-AB-induced migration.

  9. Placental endothelial cell-derived PDGF (show PDGFA Proteins)-BB recruits human placental multipotent mesenchymal stromal cells involved in vascular development via PDGFR-beta (show PDGFRB Proteins)/STAT3 (show STAT3 Proteins) activation

  10. Suggest that PDGF-B (show PDGFB Proteins) signaling may play a role in endothelial and cardiomyocyte recovery from ischemia reperfusion injury after heart transplantation.

PDGFBB Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with PDGFBB

  • platelet-derived growth factor beta polypeptide (PDGFB)
  • c-sis protein
  • PDGF-2 protein
  • PDGF2 protein
  • SIS protein
  • SSV protein

Protein level used designations for PDGFBB

PDGF subunit B , PDGF, B chain , becaplermin , platelet-derived growth factor 2 , platelet-derived growth factor B chain , platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) , platelet-derived growth factor subunit B , platelet-derived growth factor, beta polypeptide (oncogene SIS) , proto-oncogene c-Sis

5155 Homo sapiens
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