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Browse our Pleiotrophin Proteins (PTN)

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Pleiotrophin Proteins (PTN)
On are 37 Pleiotrophin (PTN) Proteins from 13 different suppliers available. Additionally we are shipping Pleiotrophin Antibodies (125) and Pleiotrophin Kits (55) and many more products for this protein. A total of 225 Pleiotrophin products are currently listed.
HARP, HB-GAM, HBBM, HBBN, HBGF-8, HBGF8, Hbnf, NEGF1, OSF, Osf-1, Osf1, PTN, PTN-A, X-PTF, zgc:111787, zHBNF
list all proteins Gene Name GeneID UniProt
PTN 5764 P21246
PTN 19242 P63089
PTN 24924 P63090

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Pleiotrophin Proteins (PTN) by Origin

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Top referenced Pleiotrophin Proteins

  1. Mouse (Murine) Pleiotrophin Protein expressed in Baculovirus infected Insect Cells - ABIN2008500 : Lauri, Taira, Kaila, Rauvala: Activity-induced enhancement of HB-GAM expression in rat hippocampal slices. in Neuroreport 1997 (PubMed)

More Proteins for Pleiotrophin Interaction Partners

Zebrafish Pleiotrophin (PTN) interaction partners

  1. zebrafish HBNF was able to enhance extensive neurite outgrowth in zebrafish embryos during embryogenesis

Pig (Porcine) Pleiotrophin (PTN) interaction partners

Human Pleiotrophin (PTN) interaction partners

  1. PTN could be considered as a potential biomarker for the presence of breast cancer.

  2. this study shows that the expression of PTN is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts

  3. findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.

  4. PTN levels in amniotic fluid were found to be lower in pregnancies complicated by chorioamnionitis than in healthy pregnancies.

  5. Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer

  6. Data show that binding of pleiotrophin (PTN) to neuropilin-1 (NRP-1 (show NRP1 Proteins)) stimulated the internalization and recycling of NRP-1 (show NELL1 Proteins) at the cell surface.

  7. PTN and its signaling components may be of significance in the pathogenesis of epithelial ovarian cancer.

  8. High serum pleiotrophin levels are associated with non-small cell lung cancer.

  9. PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes.

  10. PTN expression in glioma was higher than in paratumor tissues. Overexpression was associated with the WHO grade, low Karnofsky score, time to recurrence, and poor survival. Co-expression of midkine (show MDK Proteins) and PTN had a worse prognosis than either alone.

Mouse (Murine) Pleiotrophin (PTN) interaction partners

  1. findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.

  2. antagonizes Brd2 (show BRD2 Proteins) promoting cell differentiation associated with the neural tube: spinal cord neurogenesis and neural crest migration

  3. PTN-mediated hematopoietic regeneration occurs in a RAS-dependent manner.

  4. the absence of PTN in vivo is associated with disruption of specific cognitive and affective processes

  5. The results of this study indicated that PTN may be a novel genetic factor of importance in alcohol use disorders.

  6. data suggest that the spinal antinociceptive effects caused by stimulation of alpha2-adrenoceptors are differentially regulated by endogenous expression of PTN

  7. PTN overexpression exerts various effects on sarcolemma ion channel expression/function and resting cytosolic calcium concentrations in soleus and extensor digitorum longus muscles.

  8. Vivarium-housed Wt controls had higher levels of active TGF-beta1 (show TGFB1 Proteins) and IL-2 (show IL2 Proteins) in inguinal lymph nodes relative to PTN-Tg mice.

  9. Pleiotrophin exerts a neuroprotective role against amphetaine-induced neurotoxicity in striatum.

  10. the data demonstrate that maintenance of amphetamine-induced conditioning effects depend on the endogenous expression of PTN.

Pleiotrophin (PTN) Protein Profile

Protein Summary

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity).

Alternative names and synonyms associated with Pleiotrophin (PTN)

  • pleiotrophin (ptn)
  • Pleiotrophin (ptn)
  • pleiotrophic factor beta (PTF-BETA)
  • pleiotrophin (PTN)
  • pleiotrophin (Ptn)
  • pleiotrophin-like (LOC100351242)
  • HARP protein
  • HB-GAM protein
  • HBBM protein
  • HBBN protein
  • HBGF-8 protein
  • HBGF8 protein
  • Hbnf protein
  • NEGF1 protein
  • OSF protein
  • Osf-1 protein
  • Osf1 protein
  • PTN protein
  • PTN-A protein
  • X-PTF protein
  • zgc:111787 protein
  • zHBNF protein

Protein level used designations for Pleiotrophin Proteins (PTN)

heparin-binding neurite-promoting factor , pleiotrophin , pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) , Pleiotrophin , HB-GAM , HBBM , HBGF-8 , HBNF-1 , OSF-1 , heparin affin regulatory protein , heparin binding growth factor 8 , heparin-binding brain mitogen , heparin-binding growth factor 8 , heparin-binding growth-associated molecule , heparin-binding neurite outgrowth-promoting factor 1 , neurite growth-promoting factor 1 , osteoblast-specific factor 1 , PTF-beta-1 , X-PTF-beta1 , pleiotrophic factor-beta-1 , pleiotrophin-A , heparin-binding neutrophic factor , p18 , heparin affin regulatory peptide , heparin-binding neurite promoting factor , heparin-binding neurotorphic factor , osteoblastic cell factor , Pleiotrophin (Heparine binding factor, Hbnf, in the mouse) , heparin binding factor

368211 Danio rerio
100101785 Xenopus (Silurana) tropicalis
100286427 Salmo salar
397609 Sus scrofa
5764 Homo sapiens
444715 Xenopus laevis
418125 Gallus gallus
475509 Canis lupus familiaris
280904 Bos taurus
19242 Mus musculus
24924 Rattus norvegicus
100722746 Cavia porcellus
101103149 Ovis aries
100351242 Oryctolagus cuniculus
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